O22779 (TRL13_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thioredoxin-like 1-3, chloroplastic

Alternative name(s):
Atypical cysteine/histidine-rich thioredoxin 3
Short name=AtACHT3
Lilium-type thioredoxin 1-3

Gene names

Ordered Locus Names:	At2g33270
ORF Names:	F4P9.4

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable thiol-disulfide oxidoreductase that may participate in various redox reactions.
Subcellular location	Plastid › chloroplast Ref.5.
Sequence similarities	Belongs to the thioredoxin family. Contains 1 thioredoxin domain.
Caution	The active site contains a CGGC motif wich differs from the conserved CGPC motif.

Ontologies

Keywords
Biological process	Electron transport Transport
Cellular component	Chloroplast Plastid
Domain	Redox-active center Transit peptide
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW glycerol ether metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	chloroplast Inferred from direct assay Ref.5. Source: TAIR
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 44	44	Chloroplast Potential
	Chain	45 – 273	229	Thioredoxin-like 1-3, chloroplastic		PRO_0000034171
Regions
	Domain	62 – 202	141	Thioredoxin
Sites
	Active site	125	1	Nucleophile Potential
	Active site	128	1	Nucleophile Potential
Amino acid modifications
	Disulfide bond	125 ↔ 128		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	O22779 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 3F6546427486FDDB	FASTA	273	30,680
	10 20 30 40 50 60 MATDSFIKLN PISFNRARFD LRDFAGISPK SISSLCCISP RLISCNHFSP RTLISGENGN 70 80 90 100 110 120 ILFSKKKIPA FVRCQTSLGI GRNQKWWEKE LKPNMKSVTS PQDLVVSLRN AGDKLVVVDF 130 140 150 160 170 180 FSPSCGGCKA LHPKICKIAE KNPEVEFLQV NYEEHRSLCQ SLNIHVLPFF RFYRGSSGRV 190 200 210 220 230 240 CSFSCTNATI RKFKEALEKH GREQCSIGET KGLEEKELVA MAANKDLSFD YKPTSCGNIQ 250 260 270 EQKKKEIFLP KSPTFNKQKE VEHSLLLVSP APA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana." Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C. Nature 402:761-768(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W., Redman J.C., Wu H.C., Utterback T., Town C.D. Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[4]	"Comparative genomic study of the thioredoxin family in photosynthetic organisms with emphasis on Populus trichocarpa." Chibani K., Wingsle G., Jacquot J.P., Gelhaye E., Rouhier N. Mol. Plant 2:308-322(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
[5]	"A small family of chloroplast atypical thioredoxins." Dangoor I., Peled-Zehavi H., Levitan A., Pasand O., Danon A. Plant Physiol. 149:1240-1250(2009) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC002332 Genomic DNA. Translation: AAB80645.1. CP002685 Genomic DNA. Translation: AEC08808.1. DQ056563 mRNA. Translation: AAY78713.1.
IPI	IPI00547365.
PIR	D84743.
RefSeq	NP_180885.1. NM_128887.2.
UniGene	At.53018.
3D structure databases
ProteinModelPortal	O22779.
SMR	O22779. Positions 111-175.
ModBase	Search...
Protein-protein interaction databases
IntAct	O22779. 1 interaction.
STRING	3702.AT2G33270.1-P.
Proteomic databases
PaxDb	O22779.
PRIDE	O22779.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT2G33270.1; AT2G33270.1; AT2G33270.
GeneID	817890.
KEGG	ath:AT2G33270.
Organism-specific databases
GeneFarm	2493. 215.
TAIR	At2g33270.
Phylogenomic databases
eggNOG	NOG322880.
HOGENOM	HOG000154691.
InParanoid	O22779.
OMA	PRTLISG.
PhylomeDB	O22779.
ProtClustDB	CLSN2913076.
Gene expression databases
Genevestigator	O22779.
GermOnline	AT2G33270. Arabidopsis thaliana.
Family and domain databases
Gene3D	3.40.30.10. 1 hit.
InterPro	IPR005746. Thioredoxin. IPR012336. Thioredoxin-like_fold. IPR013766. Thioredoxin_domain. [Graphical view]
PANTHER	PTHR10438. PTHR10438. 1 hit.
Pfam	PF00085. Thioredoxin. 1 hit. [Graphical view]
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS00194. THIOREDOXIN_1. False negative. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRL13_ARATH

Accession

Primary (citable) accession number: O22779
Secondary accession number(s): Q4PSS3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2004
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program