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Protein

Basic leucine zipper 10

Gene

BZIP10

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that binds to the C-box-like motif (5'-TGCTGACGTCA-3') and G-box-like motif (5'-CCACGTGGCC-3'), ABRE elements, of gene promoters. Binds to the 5'-ACGT-3' motif of seed storage protein (SSP) encoding gene promoters (e.g. At2S and CRU3) and promotes their expression in seeds when in complex with ABI3 and BZIP53. Involved in the defense responses to the biotrophic pathogen Hyaloperonospora parasitica and oxidative stress responses; mediates positively cell death (PubMed:12657652, PubMed:16957775, PubMed:19261733, PubMed:19531597). Promotes BZIP53-mediated response to hypoosmolarity stress that leads to POX1/PRODH1 accumulation (PubMed:16810321).5 Publications

GO - Molecular functioni

  • nutrient reservoir activity Source: UniProtKB-KW
  • protein heterodimerization activity Source: TAIR
  • sequence-specific DNA binding Source: TAIR
  • transcription factor activity, sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • plant-type hypersensitive response Source: TAIR
  • positive regulation of seed maturation Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • response to molecule of oomycetes origin Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Seed storage protein, Storage protein

Keywords - Biological processi

Hypersensitive response, Plant defense, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Basic leucine zipper 10
Short name:
AtbZIP10
Short name:
bZIP protein 10
Alternative name(s):
Basic leucine zipper OPAQUE 2 homolog 1
Short name:
Basic leucine zipper O2 homolog 1
Gene namesi
Name:BZIP10
Synonyms:BZO2H1
Ordered Locus Names:At4g02640
ORF Names:T10P11.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G02640.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: TAIR
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004165581 – 411Basic leucine zipper 10Add BLAST411

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei196PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO22763.

PTM databases

iPTMnetiO22763.

Expressioni

Tissue specificityi

Expressed in roots, shoots, stems, young leaves, trichomes, hydathodes, siliques, seeds, and flowers, mostly in vascular tissues.2 Publications

Developmental stagei

First observed in carpels and seeds at early stages of development, mostly in embryo and, at lower extent, in the endosperm. Accumulates and peaks at maturation. Fade out during late seed development steps, restricted to the inner layer of the seed coat, and, at very low levels, in the mature embryo and the remaining endosperm. Also present in the lignified inner subepidermal layer of the valves. In the anthers, restricted to the connective tissue at pre- and post-dehiscence stages and detected in the vascular tissue of the stamen filament.2 Publications

Gene expression databases

GenevisibleiO22763. AT.

Interactioni

Subunit structurei

Forms a heterodimer with BZIP1, BZIP2, BZIP9, BZIP11, BZIP44, BZIP53 and BZIP63. Interacts with ABI3 and forms a complex made of ABI3, BZIP53 and BZIP10. Binding with LSD1 leads to cytoplasmic retention.7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BZIP1Q9FGX23EBI-942648,EBI-942623
BZIP11O656833EBI-942648,EBI-942769
BZIP2Q9SI153EBI-942648,EBI-942735
BZIP44C0Z2L53EBI-942648,EBI-942804
BZIP53Q9LZP88EBI-942648,EBI-942845

GO - Molecular functioni

  • protein heterodimerization activity Source: TAIR

Protein-protein interaction databases

BioGridi13508. 12 interactors.
IntActiO22763. 17 interactors.
STRINGi3702.AT4G02640.2.

Structurei

3D structure databases

ProteinModelPortaliO22763.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini215 – 278bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni217 – 236Basic motifPROSITE-ProRule annotationAdd BLAST20
Regioni243 – 257Leucine-zipperPROSITE-ProRule annotationAdd BLAST15

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi219 – 226Nuclear localization signalBy similarity8

Sequence similaritiesi

Belongs to the bZIP family.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410JW8E. Eukaryota.
ENOG4110561. LUCA.
HOGENOMiHOG000240492.
InParanoidiO22763.
OMAiGQNDFED.
PhylomeDBiO22763.

Family and domain databases

InterProiIPR020983. Basic_leucine-zipper_C.
IPR004827. bZIP.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
PF12498. bZIP_C. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O22763-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSIFSIDDF SDPFWETPPI PLNPDSSKPV TADEVSQSQP EWTFEMFLEE
60 70 80 90 100
ISSSAVSSEP LGNNNNAIVG VSSAQSLPSV SGQNDFEDDS RFRDRDSGNL
110 120 130 140 150
DCAAPMTTKT VIVDSDDYRR VLKNKLETEC ATVVSLRVGS VKPEDSTSSP
160 170 180 190 200
ETQLQPVQSS PLTQGELGVT SSLPAEVKKT GVSMKQVTSG SSREYSDDED
210 220 230 240 250
LDEENETTGS LKPEDVKKSR RMLSNRESAR RSRRRKQEQT SDLETQVNDL
260 270 280 290 300
KGEHSSLLKQ LSNMNHKYDE AAVGNRILKA DIETLRAKVK MAEETVKRVT
310 320 330 340 350
GMNPMLLGRS SGHNNNNRMP ITGNNRMDSS SIIPAYQPHS NLNHMSNQNI
360 370 380 390 400
GIPTILPPRL GNNFAAPPSQ TSSPLQRIRN GQNHHVTPSA NPYGWNTEPQ
410
NDSAWPKKCV D
Length:411
Mass (Da):45,358
Last modified:January 1, 1999 - v2
Checksum:i9C651436D8D167CF
GO
Isoform 2 (identifier: O22763-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     406-411: Missing.

Note: No experimental confirmation available.
Show »
Length:405
Mass (Da):44,687
Checksum:iC7CFB2C2CA4F5996
GO
Isoform 3 (identifier: O22763-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     164-164: Q → QGSLMTP

Note: No experimental confirmation available.
Show »
Length:417
Mass (Da):45,945
Checksum:i271EE03719335A12
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042639164Q → QGSLMTP in isoform 3. 2 Publications1
Alternative sequenceiVSP_042640406 – 411Missing in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010859 mRNA. Translation: CAC79657.1.
AF310222 mRNA. Translation: AAG25727.1.
AC002330 Genomic DNA. Translation: AAC78255.1.
AL161494 Genomic DNA. Translation: CAB80757.1.
CP002687 Genomic DNA. Translation: AEE82207.1.
CP002687 Genomic DNA. Translation: AEE82208.1.
AK318728 mRNA. Translation: BAH56843.1.
AY080854 mRNA. Translation: AAL87327.1.
BT025558 mRNA. Translation: ABF58976.1.
AY088417 mRNA. Translation: AAM65954.1.
PIRiT01085.
RefSeqiNP_192173.1. NM_116498.4. [O22763-1]
NP_849290.1. NM_178959.3. [O22763-3]
UniGeneiAt.25176.

Genome annotation databases

EnsemblPlantsiAT4G02640.1; AT4G02640.1; AT4G02640. [O22763-1]
GeneIDi828219.
GrameneiAT4G02640.1; AT4G02640.1; AT4G02640.
KEGGiath:AT4G02640.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010859 mRNA. Translation: CAC79657.1.
AF310222 mRNA. Translation: AAG25727.1.
AC002330 Genomic DNA. Translation: AAC78255.1.
AL161494 Genomic DNA. Translation: CAB80757.1.
CP002687 Genomic DNA. Translation: AEE82207.1.
CP002687 Genomic DNA. Translation: AEE82208.1.
AK318728 mRNA. Translation: BAH56843.1.
AY080854 mRNA. Translation: AAL87327.1.
BT025558 mRNA. Translation: ABF58976.1.
AY088417 mRNA. Translation: AAM65954.1.
PIRiT01085.
RefSeqiNP_192173.1. NM_116498.4. [O22763-1]
NP_849290.1. NM_178959.3. [O22763-3]
UniGeneiAt.25176.

3D structure databases

ProteinModelPortaliO22763.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi13508. 12 interactors.
IntActiO22763. 17 interactors.
STRINGi3702.AT4G02640.2.

PTM databases

iPTMnetiO22763.

Proteomic databases

PaxDbiO22763.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G02640.1; AT4G02640.1; AT4G02640. [O22763-1]
GeneIDi828219.
GrameneiAT4G02640.1; AT4G02640.1; AT4G02640.
KEGGiath:AT4G02640.

Organism-specific databases

TAIRiAT4G02640.

Phylogenomic databases

eggNOGiENOG410JW8E. Eukaryota.
ENOG4110561. LUCA.
HOGENOMiHOG000240492.
InParanoidiO22763.
OMAiGQNDFED.
PhylomeDBiO22763.

Miscellaneous databases

PROiO22763.

Gene expression databases

GenevisibleiO22763. AT.

Family and domain databases

InterProiIPR020983. Basic_leucine-zipper_C.
IPR004827. bZIP.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
PF12498. bZIP_C. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBZP10_ARATH
AccessioniPrimary (citable) accession number: O22763
Secondary accession number(s): C0Z2B4, Q8RXJ3, Q9FUD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: January 1, 1999
Last modified: November 30, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.