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Protein

Profilin-4

Gene

PRO4

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Has a high affinity for poly-proline.

GO - Molecular functioni

  • actin monomer binding Source: AgBase
  • proline-rich region binding Source: AgBase

GO - Biological processi

  • nuclear migration Source: AgBase
  • pollen development Source: AgBase
  • pollen tube growth Source: AgBase
  • regulation of actin cytoskeleton organization Source: AgBase
  • sequestering of actin monomers Source: AgBase

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Profilin-4
Alternative name(s):
Pollen allergen Zea m 12
ZmPRO4
Allergen: Zea m 12
Gene namesi
Name:PRO4
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Chromosome 6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3538. Zea m 12.0104.
682. Zea m 12.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001996492 – 131Profilin-4Add BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi13 ↔ 115Curated
Modified residuei111PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated by MAP kinases.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiO22655.
PRIDEiO22655.

Expressioni

Tissue specificityi

Expressed predominantly in endosperm but is also found at low levels in all tissues examined, including mature and germinated pollen.

Gene expression databases

ExpressionAtlasiO22655. baseline.
GenevisibleiO22655. ZM.

Interactioni

Subunit structurei

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

GO - Molecular functioni

  • actin monomer binding Source: AgBase
  • proline-rich region binding Source: AgBase

Protein-protein interaction databases

STRINGi4577.GRMZM2G108780_P01.

Structurei

3D structure databases

ProteinModelPortaliO22655.
SMRiO22655.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi81 – 97Involved in PIP2 interactionAdd BLAST17

Sequence similaritiesi

Belongs to the profilin family.Curated

Phylogenomic databases

eggNOGiKOG1755. Eukaryota.
ENOG41126PD. LUCA.
HOGENOMiHOG000171591.
KOiK05759.
OMAiFPQFTAE.
OrthoDBiEOG09360WEB.

Family and domain databases

CDDicd00148. PROF. 1 hit.
InterProiView protein in InterPro
IPR005455. PFN.
IPR027310. Profilin_CS.
PANTHERiPTHR11604. PTHR11604. 1 hit.
PfamiView protein in Pfam
PF00235. Profilin. 1 hit.
PRINTSiPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTiView protein in SMART
SM00392. PROF. 1 hit.
SUPFAMiSSF55770. SSF55770. 1 hit.
PROSITEiView protein in PROSITE
PS00414. PROFILIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O22655-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWQAYVDEH LMCEIEGQHL SAAAIVGHDG SVWAQSESFP ELKPEEVAGI
60 70 80 90 100
IKDFDEPGTL APTGLFVGGT KYMVIQGEPG VVIRGKKGTG GITIKKTGMS
110 120 130
LIIGVYDEPM TPGQCNMVVE RLGDYLIEQG F
Length:131
Mass (Da):14,101
Last modified:January 1, 1998 - v1
Checksum:iE0744573FAADBE85
GO

Polymorphismi

Several isoforms of the allergen exist due to polymorphism.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032370 mRNA. Translation: AAB86960.1.
PIRiT01328.
RefSeqiNP_001104885.1. NM_001111415.1.
UniGeneiZm.1859.

Genome annotation databases

EnsemblPlantsiZm00001d036213_T001; Zm00001d036213_P001; Zm00001d036213.
GeneIDi541662.
GrameneiZm00001d036213_T001; Zm00001d036213_P001; Zm00001d036213.
KEGGizma:541662.

Similar proteinsi

Entry informationi

Entry nameiPROF4_MAIZE
AccessioniPrimary (citable) accession number: O22655
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: August 30, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families