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O22652

- CHSY_RAPSA

UniProt

O22652 - CHSY_RAPSA

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Protein

Chalcone synthase

Gene
CHS
Organism
Raphanus sativus (Radish)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei168 – 1681 By similarity

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase
Gene namesi
Name:CHS
OrganismiRaphanus sativus (Radish)
Taxonomic identifieri3726 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeBrassiceaeRaphanus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Chalcone synthasePRO_0000216044Add
BLAST

Proteomic databases

PRIDEiO22652.

Structurei

3D structure databases

ProteinModelPortaliO22652.
SMRiO22652. Positions 7-394.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O22652-1 [UniParc]FASTAAdd to Basket

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MVGTTSSLDE IRKAQRADGP AGILAIGTAN PANHVLQAEY PDYYFRITNS    50
EHMTDLKEKF KRMCDKSTIR KRHMHLTEEF LKENPNMCAY MAPSLDARQD 100
IVVVEVPKLG KEAAVKAIKE WGQPKSKITH VVFCTTSGVD MPGADYQLTK 150
LLGLRPSVKR LMMYQQGCFA GGTVLRLAKD LAENNRGARV LVVCSEITAV 200
TFRGPSDTHL DSLVGQALFS DGAAALIVGS DPDVSAGEKP IFEMVSAAQT 250
ILPDSDGAID GHLREVGITF HLLKDVPGLI SKNIEKSLDE AFKPLGISDW 300
NSLFWIAHPG GPAILDDVEK KLGLKAEKMR ATRHVLSEYG NMSSACVLFI 350
LDEMRRKSLD DGVATTGEGL EWGVLFGFGP GLTVETVVLH SVPV 394
Length:394
Mass (Da):42,892
Last modified:January 1, 1998 - v1
Checksum:i5324498DFCB13DB0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF031922 mRNA. Translation: AAB87072.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF031922 mRNA. Translation: AAB87072.1 .

3D structure databases

ProteinModelPortali O22652.
SMRi O22652. Positions 7-394.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi O22652.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00154 .

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000451. PKS_III. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Kwon S.I., An C.-S.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCHSY_RAPSA
AccessioniPrimary (citable) accession number: O22652
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: February 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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