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Protein

Ornithine decarboxylase

Gene

ODC

Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-ornithine = putrescine + CO2.

Cofactori

Pathwayi: putrescine biosynthesis via L-ornithine pathway

This protein is involved in step 1 of the subpathway that synthesizes putrescine from L-ornithine.
Proteins known to be involved in this subpathway in this organism are:
  1. Ornithine decarboxylase (ODC)
This subpathway is part of the pathway putrescine biosynthesis via L-ornithine pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes putrescine from L-ornithine, the pathway putrescine biosynthesis via L-ornithine pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei376 – 3761Proton donor; shared with dimeric partnerBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14991.
UniPathwayiUPA00535; UER00288.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine decarboxylase (EC:4.1.1.17)
Short name:
ODC
Alternative name(s):
LeODC
Gene namesi
Name:ODC
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
Proteomesi
  • UP000004994 Componenti: Chromosome 4

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431Ornithine decarboxylasePRO_0000239255Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei94 – 941N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PaxDbiO22616.
PRIDEiO22616.

Expressioni

Tissue specificityi

High expression in roots, shoot tips and whole flowers at anthesis. Lower expression in stems and the lowest in adult leaves.1 Publication

Developmental stagei

Transient induction at 8 days post-anthesis. ODC activity seems to be related to active cell division.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi4081.Solyc04g082030.1.1.

Structurei

3D structure databases

ProteinModelPortaliO22616.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0622. Eukaryota.
COG0019. LUCA.
InParanoidiO22616.
KOiK01581.
OMAiVTYAVKS.
OrthoDBiEOG09360CAQ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O22616-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGQTVIVSG LNPAAILQST IGGAPVAAAA ENGHTRKVVP LSKDALQDFM
60 70 80 90 100
VSIITQKLQD DKQPFYVLDL GEVVSLMEQW NSALPNIRPF YAVKCNPEPS
110 120 130 140 150
FLSMLSAMGS NFDCASRAEI EYVLSHGISP DRIVFANPCK PESDIIFAEK
160 170 180 190 200
IGVNLTTYDS EDEVYKIRKH HPKCELLLRI KPMTDGNARC PMGPKYGALP
210 220 230 240 250
EEIEPLLRTA QAARLTVSGV SFHIGSGDAD SNAYLGAIAA AKQVFETAAQ
260 270 280 290 300
LGMPKMTVLD IGGGFTSGHQ FTTAAPAVKS ALETHFHDFP ELTIIAEPGR
310 320 330 340 350
FFAETAFTLA TTIIGKRVRG ELKEYWINDG LYGSMNCVLY DHATVTATPL
360 370 380 390 400
ACMSNRNNLN CGGSKTFPST VFGPTCDALD TVLRDYQLPE LQVNDWLIFP
410 420 430
NMGAYTKAAG SNFNGFNTSA IVTHLAYAYP N
Length:431
Mass (Da):46,647
Last modified:March 1, 2001 - v2
Checksum:iB126D4FECEAE305D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029349 mRNA. Translation: AAB82301.2.
AF030292 mRNA. Translation: AAC61845.1.
RefSeqiNP_001234616.1. NM_001247687.1.
UniGeneiLes.3525.

Genome annotation databases

EnsemblPlantsiSolyc04g082030.1.1; Solyc04g082030.1.1; Solyc04g082030.1.
GeneIDi544209.
GrameneiSolyc04g082030.1.1; Solyc04g082030.1.1; Solyc04g082030.1.
KEGGisly:544209.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029349 mRNA. Translation: AAB82301.2.
AF030292 mRNA. Translation: AAC61845.1.
RefSeqiNP_001234616.1. NM_001247687.1.
UniGeneiLes.3525.

3D structure databases

ProteinModelPortaliO22616.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4081.Solyc04g082030.1.1.

Proteomic databases

PaxDbiO22616.
PRIDEiO22616.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiSolyc04g082030.1.1; Solyc04g082030.1.1; Solyc04g082030.1.
GeneIDi544209.
GrameneiSolyc04g082030.1.1; Solyc04g082030.1.1; Solyc04g082030.1.
KEGGisly:544209.

Phylogenomic databases

eggNOGiKOG0622. Eukaryota.
COG0019. LUCA.
InParanoidiO22616.
KOiK01581.
OMAiVTYAVKS.
OrthoDBiEOG09360CAQ.

Enzyme and pathway databases

UniPathwayiUPA00535; UER00288.
BioCyciMetaCyc:MONOMER-14991.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCOR_SOLLC
AccessioniPrimary (citable) accession number: O22616
Secondary accession number(s): O82420
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.