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Protein

Zinc finger protein ZAT6

Gene

ZAT6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable transcription factor that regulates root development and phosphate (Pi) acquisition and homeostasis. Probably acts as a repressor of primary root growth and regulates Pi homeostasis through the control of root architecture.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri89 – 11123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri148 – 17023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • core promoter binding Source: TAIR
  • metal ion binding Source: UniProtKB-KW
  • sequence-specific DNA binding Source: GO_Central
  • transcription factor activity, sequence-specific DNA binding Source: TAIR
  • transcription regulatory region DNA binding Source: TAIR

GO - Biological processi

  • phosphate ion homeostasis Source: UniProtKB
  • regulation of root development Source: UniProtKB
  • response to chitin Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZAT6
Alternative name(s):
COLD INDUCED ZINC FINGER PROTEIN 2
Gene namesi
Name:ZAT6
Synonyms:CZF2
Ordered Locus Names:At5g04340
ORF Names:T19N18.70
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G04340.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238Zinc finger protein ZAT6PRO_0000409715Add
BLAST

Proteomic databases

PaxDbiO22533.

PTM databases

iPTMnetiO22533.

Expressioni

Inductioni

By cold treatment and during Pi starvation.2 Publications

Gene expression databases

GenevisibleiO22533. AT.

Interactioni

Protein-protein interaction databases

BioGridi15592. 3 interactions.
STRINGi3702.AT5G04340.1.

Structurei

3D structure databases

ProteinModelPortaliO22533.
SMRiO22533. Positions 82-121, 137-176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi30 – 389Nuclear localization signalSequence analysis

Sequence similaritiesi

Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri89 – 11123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri148 – 17023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000240166.
InParanoidiO22533.
OMAiDEYIALC.
PhylomeDBiO22533.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O22533-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALETLTSPR LSSPMPTLFQ DSALGFHGSK GKRSKRSRSE FDRQSLTEDE
60 70 80 90 100
YIALCLMLLA RDGDRNRDLD LPSSSSSPPL LPPLPTPIYK CSVCDKAFSS
110 120 130 140 150
YQALGGHKAS HRKSFSLTQS AGGDELSTSS AITTSGISGG GGGSVKSHVC
160 170 180 190 200
SICHKSFATG QALGGHKRCH YEGKNGGGVS SSVSNSEDVG STSHVSSGHR
210 220 230
GFDLNIPPIP EFSMVNGDEE VMSPMPAKKL RFDFPEKP
Length:238
Mass (Da):25,252
Last modified:January 1, 1998 - v1
Checksum:iC3FCC19585477A34
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti236 – 2361E → G in BAC43454 (PubMed:11910074).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022658 mRNA. Translation: AAB80922.1.
CP002688 Genomic DNA. Translation: AED90729.1.
AK118868 mRNA. Translation: BAC43454.1.
RefSeqiNP_196054.1. NM_120516.3.
UniGeneiAt.65029.

Genome annotation databases

EnsemblPlantsiAT5G04340.1; AT5G04340.1; AT5G04340.
GeneIDi830313.
GrameneiAT5G04340.1; AT5G04340.1; AT5G04340.
KEGGiath:AT5G04340.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022658 mRNA. Translation: AAB80922.1.
CP002688 Genomic DNA. Translation: AED90729.1.
AK118868 mRNA. Translation: BAC43454.1.
RefSeqiNP_196054.1. NM_120516.3.
UniGeneiAt.65029.

3D structure databases

ProteinModelPortaliO22533.
SMRiO22533. Positions 82-121, 137-176.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi15592. 3 interactions.
STRINGi3702.AT5G04340.1.

PTM databases

iPTMnetiO22533.

Proteomic databases

PaxDbiO22533.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G04340.1; AT5G04340.1; AT5G04340.
GeneIDi830313.
GrameneiAT5G04340.1; AT5G04340.1; AT5G04340.
KEGGiath:AT5G04340.

Organism-specific databases

TAIRiAT5G04340.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000240166.
InParanoidiO22533.
OMAiDEYIALC.
PhylomeDBiO22533.

Miscellaneous databases

PROiO22533.

Gene expression databases

GenevisibleiO22533. AT.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "C2H2 zinc finger type domains in Arabidopsis thaliana."
    Jensen R.B., Skriver K., Jespersen H.M.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Columbia.
  2. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Roles of the CBF2 and ZAT12 transcription factors in configuring the low temperature transcriptome of Arabidopsis."
    Vogel J.T., Zarka D.G., Van Buskirk H.A., Fowler S.G., Thomashow M.F.
    Plant J. 41:195-211(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY COLD.
  6. "Phosphate homeostasis and root development in Arabidopsis are synchronized by the zinc finger transcription factor ZAT6."
    Devaiah B.N., Nagarajan V.K., Raghothama K.G.
    Plant Physiol. 145:147-159(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION.

Entry informationi

Entry nameiZAT6_ARATH
AccessioniPrimary (citable) accession number: O22533
Secondary accession number(s): Q8GWG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Seeds silencing ZAT6 fail to germinate. Plants overexpressing ZAT6 have retarded growth with smaller primary roots and fewer leaves.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.