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Protein

WD-40 repeat-containing protein MSI3

Gene

MSI3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA.By similarity

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-ATH-212300 PRC2 methylates histones and DNA
R-ATH-2559580 Oxidative Stress Induced Senescence
R-ATH-3214847 HATs acetylate histones
R-ATH-3214858 RMTs methylate histone arginines
R-ATH-8951664 Neddylation
R-ATH-8953750 Transcriptional Regulation by E2F6

Names & Taxonomyi

Protein namesi
Recommended name:
WD-40 repeat-containing protein MSI3
Gene namesi
Name:MSI3
Ordered Locus Names:At4g35050
ORF Names:M4E13.110
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G35050
TAIRilocus:2131551 AT4G35050

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000510821 – 424WD-40 repeat-containing protein MSI3Add BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiO22469
PRIDEiO22469

Expressioni

Gene expression databases

ExpressionAtlasiO22469 baseline and differential
GenevisibleiO22469 AT

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DDB1AQ9M0V32EBI-1632794,EBI-1632780

Protein-protein interaction databases

BioGridi14939, 2 interactors
IntActiO22469, 1 interactor
STRINGi3702.AT4G35050.1

Structurei

3D structure databases

ProteinModelPortaliO22469
SMRiO22469
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati167 – 207WD 1Add BLAST41
Repeati216 – 256WD 2Add BLAST41
Repeati259 – 299WD 3Add BLAST41
Repeati303 – 343WD 4Add BLAST41
Repeati362 – 402WD 5Add BLAST41

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi233 – 249DWD boxAdd BLAST17

Domaini

The DWD box is required for interaction with DDB1A.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0264 Eukaryota
ENOG410XNU9 LUCA
HOGENOMiHOG000160330
InParanoidiO22469
KOiK10752
OMAiHGGHMLG
OrthoDBiEOG09360A5S
PhylomeDBiO22469

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR022052 Histone-bd_RBBP4_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12265 CAF1C_H4-bd, 1 hit
PF00400 WD40, 4 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

O22469-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEEGKDEA GLDQVEEEFS IWKRNTPFLY DLMISHPLEW PSLTLHWVPS
60 70 80 90 100
TPIPYSKDPY FAVHKLILGT HTSGGAQDFL MVADVVIPTP DAEPGLGGRD
110 120 130 140 150
QEPIVPKVEI KQKIRVDGEV NRARCMPQKP TLVGAKTSGS EVFLFDYARL
160 170 180 190 200
SGKPQTSECD PDLRLMGHEQ EGYGLAWSSF KEGYLLSGSQ DQRICLWDVS
210 220 230 240 250
ATATDKVLNP MHVYEGHQSI IEDVAWHMKN ENIFGSAGDD CQLVIWDLRT
260 270 280 290 300
NQMQHQVKVH EREINYLSFN PFNEWVLATA SSDSTVALFD LRKLTAPLHV
310 320 330 340 350
LSKHEGEVFQ VEWDPNHETV LASSGEDRRL MVWDINRVGD EQLEIELDAE
360 370 380 390 400
DGPPELLFSH GGHKAKISDF AWNKDEPWVI SSVAEDNSLQ VWQMAESIYR
410 420
EDDEDEDDDD EGNQNAQHSN ENQK
Length:424
Mass (Da):47,983
Last modified:January 11, 2001 - v2
Checksum:iD83E2B4913468A0A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti223 – 224DV → EL in AAB70244 (PubMed:9338962).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016848 mRNA Translation: AAB70244.1
AL022023 Genomic DNA Translation: CAA17770.1
AL161586 Genomic DNA Translation: CAB80222.1
CP002687 Genomic DNA Translation: AEE86455.1
PIRiT05775
RefSeqiNP_195231.1, NM_119671.3
UniGeneiAt.2099

Genome annotation databases

EnsemblPlantsiAT4G35050.1; AT4G35050.1; AT4G35050
GeneIDi829657
GrameneiAT4G35050.1; AT4G35050.1; AT4G35050
KEGGiath:AT4G35050

Similar proteinsi

Entry informationi

Entry nameiMSI3_ARATH
AccessioniPrimary (citable) accession number: O22469
Secondary accession number(s): O49612
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 11, 2001
Last modified: May 23, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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