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Protein

Histone deacetylase 19

Gene

HDA19

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDA19 is involved in jasmonic acid and ethylene signaling of pathogen response. Part of a repressor complex including APETALA2 (AP2) and TOPLESS (TPL) that control the expression domains of numerous floral organ identity genes (PubMed:23034631).5 Publications

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei149By similarity1

GO - Molecular functioni

GO - Biological processi

  • DNA mediated transformation Source: TAIR
  • histone acetylation Source: TAIR
  • jasmonic acid and ethylene-dependent systemic resistance Source: TAIR
  • negative regulation of transcription, DNA-templated Source: TAIR
  • pathogenesis Source: TAIR
  • positive regulation of stem cell population maintenance Source: TAIR
  • regulation of multicellular organismal development Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BRENDAi3.5.1.98. 399.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 191 Publication (EC:3.5.1.981 Publication)
Short name:
AtHD11 Publication
Short name:
HD
Gene namesi
Name:HDA191 Publication
Synonyms:HD11 Publication, HDA1, RPD3A1 Publication
Ordered Locus Names:At4g38130Imported
ORF Names:F20D10.250Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G38130.

Subcellular locationi

  • Nucleus 2 Publications

  • Note: excluded from the nucleolus, but associated with the condensing chromatids.

GO - Cellular componenti

  • histone deacetylase complex Source: TAIR
  • nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001147211 – 501Histone deacetylase 19Add BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei416PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO22446.

PTM databases

iPTMnetiO22446.

Expressioni

Tissue specificityi

Highly expressed in leaves, stems, flowers and young siliques.3 Publications

Inductioni

By jasmonic acid, ethylene, wounding and pathogen infection. Inhibited by sodium butyrate.2 Publications

Gene expression databases

ExpressionAtlasiO22446. baseline and differential.
GenevisibleiO22446. AT.

Interactioni

Subunit structurei

Interacts with SIN3, SAP18 and TPR1. Interacts with CDKE-1, MED14 and LUG. Interacts with TPL (PubMed:23034631). Interacts with AHL22 (PubMed:22442143).6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
At2g45640O646442EBI-593040,EBI-965964
SCL1Q6DLS13EBI-593040,EBI-593035From a different organism.
WRKY38Q8GWF12EBI-593040,EBI-1993263
WRKY62Q9LZV64EBI-593040,EBI-1993243

Protein-protein interaction databases

BioGridi15249. 13 interactors.
DIPiDIP-33483N.
IntActiO22446. 6 interactors.
STRINGi3702.AT4G38130.1.

Structurei

3D structure databases

ProteinModelPortaliO22446.
SMRiO22446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni17 – 329Histone deacetylaseAdd BLAST313

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1342. Eukaryota.
COG0123. LUCA.
HOGENOMiHOG000225180.
InParanoidiO22446.
KOiK06067.
OMAiNMENQNT.
OrthoDBiEOG093609CH.
PhylomeDBiO22446.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: O22446-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDTGGNSLAS GPDGVKRKVC YFYDPEVGNY YYGQGHPMKP HRIRMTHALL
60 70 80 90 100
AHYGLLQHMQ VLKPFPARDR DLCRFHADDY VSFLRSITPE TQQDQIRQLK
110 120 130 140 150
RFNVGEDCPV FDGLYSFCQT YAGGSVGGSV KLNHGLCDIA INWAGGLHHA
160 170 180 190 200
KKCEASGFCY VNDIVLAILE LLKQHERVLY VDIDIHHGDG VEEAFYATDR
210 220 230 240 250
VMTVSFHKFG DYFPGTGHIQ DIGYGSGKYY SLNVPLDDGI DDESYHLLFK
260 270 280 290 300
PIMGKVMEIF RPGAVVLQCG ADSLSGDRLG CFNLSIKGHA ECVKFMRSFN
310 320 330 340 350
VPLLLLGGGG YTIRNVARCW CYETGVALGV EVEDKMPEHE YYEYFGPDYT
360 370 380 390 400
LHVAPSNMEN KNSRQMLEEI RNDLLHNLSK LQHAPSVPFQ ERPPDTETPE
410 420 430 440 450
VDEDQEDGDK RWDPDSDMDV DDDRKPIPSR VKREAVEPDT KDKDGLKGIM
460 470 480 490 500
ERGKGCEVEV DESGSTKVTG VNPVGVEEAS VKMEEEGTNK GGAEQAFPPK

T
Length:501
Mass (Da):56,023
Last modified:June 6, 2002 - v2
Checksum:i857D2E3D16B7CC1F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69D → E in AAB66486 (Ref. 1) Curated1
Sequence conflicti69D → E in AAG28474 (PubMed:11117260).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014824 mRNA. Translation: AAB66486.1.
AF195547 mRNA. Translation: AAG28474.1.
AL035538 Genomic DNA. Translation: CAB37553.1.
AL161593 Genomic DNA. Translation: CAB80478.1.
CP002687 Genomic DNA. Translation: AEE86881.1.
AY093153 mRNA. Translation: AAM13152.1.
BT008873 mRNA. Translation: AAP68312.1.
AK226389 mRNA. Translation: BAE98535.1.
PIRiT05640.
RefSeqiNP_195526.1. NM_119974.4. [O22446-1]
UniGeneiAt.25069.

Genome annotation databases

EnsemblPlantsiAT4G38130.1; AT4G38130.1; AT4G38130. [O22446-1]
GeneIDi829969.
GrameneiAT4G38130.1; AT4G38130.1; AT4G38130.
KEGGiath:AT4G38130.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014824 mRNA. Translation: AAB66486.1.
AF195547 mRNA. Translation: AAG28474.1.
AL035538 Genomic DNA. Translation: CAB37553.1.
AL161593 Genomic DNA. Translation: CAB80478.1.
CP002687 Genomic DNA. Translation: AEE86881.1.
AY093153 mRNA. Translation: AAM13152.1.
BT008873 mRNA. Translation: AAP68312.1.
AK226389 mRNA. Translation: BAE98535.1.
PIRiT05640.
RefSeqiNP_195526.1. NM_119974.4. [O22446-1]
UniGeneiAt.25069.

3D structure databases

ProteinModelPortaliO22446.
SMRiO22446.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi15249. 13 interactors.
DIPiDIP-33483N.
IntActiO22446. 6 interactors.
STRINGi3702.AT4G38130.1.

PTM databases

iPTMnetiO22446.

Proteomic databases

PaxDbiO22446.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G38130.1; AT4G38130.1; AT4G38130. [O22446-1]
GeneIDi829969.
GrameneiAT4G38130.1; AT4G38130.1; AT4G38130.
KEGGiath:AT4G38130.

Organism-specific databases

TAIRiAT4G38130.

Phylogenomic databases

eggNOGiKOG1342. Eukaryota.
COG0123. LUCA.
HOGENOMiHOG000225180.
InParanoidiO22446.
KOiK06067.
OMAiNMENQNT.
OrthoDBiEOG093609CH.
PhylomeDBiO22446.

Enzyme and pathway databases

BRENDAi3.5.1.98. 399.

Miscellaneous databases

PROiO22446.

Gene expression databases

ExpressionAtlasiO22446. baseline and differential.
GenevisibleiO22446. AT.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetiSearch...

Entry informationi

Entry nameiHDA19_ARATH
AccessioniPrimary (citable) accession number: O22446
Secondary accession number(s): Q0WWG3, Q9SZL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 6, 2002
Last modified: November 30, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Loss-of-function mutant (antisense inhibition) has an increased level of tetraacetylated histone H4 and shows late flowering, developmental pleiotropy and increased symptoms when infected by a pathogen.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.