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Protein

rRNA N-glycosidase

Gene

LECSNA-If

Organism
Sambucus nigra (European elder)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation, Protein synthesis inhibitorUniRule annotationSAAS annotation, ToxinUniRule annotationSAAS annotation

Keywords - Biological processi

Plant defenseUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
rRNA N-glycosidaseUniRule annotation (EC:3.2.2.22UniRule annotation)
Gene namesi
Name:LECSNA-IfImported
OrganismiSambucus nigra (European elder)Imported
Taxonomic identifieri4202 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsDipsacalesAdoxaceaeSambucus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 PotentialImportedAdd
BLAST
Chaini29 – 570542 PotentialImportedPRO_5000053324Add
BLAST
Chaini29 – 308280type 2 ribosome-inactivating protein SNAIf, A chainImportedPRO_5000053325Add
BLAST
Chaini309 – 570262type 2 ribosome-inactivating protein SNAIf, B chainImportedPRO_5000053326Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO22415.
SMRiO22415. Positions 33-285, 315-566.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosome-inactivating protein family.UniRule annotation

Keywords - Domaini

SignalImported

Family and domain databases

Gene3Di3.40.420.10. 1 hit.
4.10.470.10. 1 hit.
InterProiIPR001574. Ribosome_inactivat_prot.
IPR017988. Ribosome_inactivat_prot_CS.
IPR016138. Ribosome_inactivat_prot_sub1.
IPR016139. Ribosome_inactivat_prot_sub2.
IPR017989. Ribosome_inactivat_prot_subgr.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF00652. Ricin_B_lectin. 2 hits.
PF00161. RIP. 1 hit.
[Graphical view]
PRINTSiPR00396. SHIGARICIN.
SMARTiSM00458. RICIN. 2 hits.
[Graphical view]
SUPFAMiSSF50370. SSF50370. 2 hits.
SSF56371. SSF56371. 1 hit.
PROSITEiPS50231. RICIN_B_LECTIN. 2 hits.
PS00275. SHIGA_RICIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O22415-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVVTKLLYL VVLAICGLGI HGALTHTRVT PPVYPSVSFN LTGADTYGPF
60 70 80 90 100
LRALQEKVIL GNHTAFDLPV LNPESQVSDS NRFVLVPLTN PSGDTVTLAI
110 120 130 140 150
DVVNLYVVAF SSNGRSYFFS GSTAVQRDNL FVDTTQEELN FTGNYISLER
160 170 180 190 200
QVGFGRVYIP LGPKSLAQAI SSLRTYTLSA GDTKPLARGL LVVIQMVSEA
210 220 230 240 250
ARFRYIELRI RTSITDASEF TPDLLMLSME NNWSSMSSEI QQAQPGGIFP
260 270 280 290 300
GVVQLRDERN NPIEVTNFRR LFELTYIAVL LYGCAPVTSN SYTNNAIDAQ
310 320 330 340 350
IIKMPVFRGG GYEKVCSVVE VTRRISGWDG LCVDVRDGHY IDGNTVQLGP
360 370 380 390 400
CGNECNQLWT FRTDGTIRWL GKCLTTSSSV MIYDCNTVPP EATKWVVSTD
410 420 430 440 450
GTITNPRSGL VLTAPQAAEG TALSLENNIH AARQGWTVGD VEPLVTFIVG
460 470 480 490 500
YKQMCLTENG ENNFVWLEDC VLNRVEQEWA LYGDGTIRVN SNRSLCVTSE
510 520 530 540 550
DHEPSDLIVI LKCEGSGNQR WVFNTNGTIS NPNAKLVMDV AQSNVSLRKI
560 570
ILYPPTGNPN QQWITTTQPA
Length:570
Mass (Da):62,752
Last modified:January 1, 1998 - v1
Checksum:i7D799D3A20764BA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012899 mRNA. Translation: AAC49989.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012899 mRNA. Translation: AAC49989.1.

3D structure databases

ProteinModelPortaliO22415.
SMRiO22415. Positions 33-285, 315-566.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.420.10. 1 hit.
4.10.470.10. 1 hit.
InterProiIPR001574. Ribosome_inactivat_prot.
IPR017988. Ribosome_inactivat_prot_CS.
IPR016138. Ribosome_inactivat_prot_sub1.
IPR016139. Ribosome_inactivat_prot_sub2.
IPR017989. Ribosome_inactivat_prot_subgr.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF00652. Ricin_B_lectin. 2 hits.
PF00161. RIP. 1 hit.
[Graphical view]
PRINTSiPR00396. SHIGARICIN.
SMARTiSM00458. RICIN. 2 hits.
[Graphical view]
SUPFAMiSSF50370. SSF50370. 2 hits.
SSF56371. SSF56371. 1 hit.
PROSITEiPS50231. RICIN_B_LECTIN. 2 hits.
PS00275. SHIGA_RICIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Elderberry (Sambucus nigra) contains truncated Neu5Ac(alpha-2,6)Gal/GalNAc-binding type 2 ribosome-inactivating proteins."
    Peumans W.J., Roy S., Barre A., Rouge P., van Leuven F., van Damme E.J.
    FEBS Lett. 425:35-39(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: FruitImported.

Entry informationi

Entry nameiO22415_SAMNI
AccessioniPrimary (citable) accession number: O22415
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: March 4, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.