Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O22415

- O22415_SAMNI

UniProt

O22415 - O22415_SAMNI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

rRNA N-glycosidase

Gene

LECSNA-If

Organism
Sambucus nigra (European elder)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.UniRule annotationSAAS annotation

GO - Molecular functioni

  1. rRNA N-glycosylase activity Source: UniProtKB-EC

GO - Biological processi

  1. defense response Source: UniProtKB-KW
  2. negative regulation of translation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation, Protein synthesis inhibitorUniRule annotationSAAS annotation, ToxinUniRule annotationSAAS annotation

Keywords - Biological processi

Plant defenseUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
rRNA N-glycosidaseUniRule annotation (EC:3.2.2.22UniRule annotation)
Gene namesi
Name:LECSNA-IfImported
OrganismiSambucus nigra (European elder)Imported
Taxonomic identifieri4202 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsDipsacalesAdoxaceaeSambucus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 PotentialImportedAdd
BLAST
Chaini29 – 570542 PotentialImportedPRO_5000053324Add
BLAST
Chaini29 – 308280type 2 ribosome-inactivating protein SNAIf, A chainImportedPRO_5000053325Add
BLAST
Chaini309 – 570262type 2 ribosome-inactivating protein SNAIf, B chainImportedPRO_5000053326Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO22415.
SMRiO22415. Positions 33-285, 315-566.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosome-inactivating protein family.UniRule annotation

Keywords - Domaini

SignalImported

Family and domain databases

Gene3Di3.40.420.10. 1 hit.
4.10.470.10. 1 hit.
InterProiIPR001574. Ribosome_inactivat_prot.
IPR017988. Ribosome_inactivat_prot_CS.
IPR016138. Ribosome_inactivat_prot_sub1.
IPR016139. Ribosome_inactivat_prot_sub2.
IPR017989. Ribosome_inactivat_prot_subgr.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF00652. Ricin_B_lectin. 2 hits.
PF00161. RIP. 1 hit.
[Graphical view]
PRINTSiPR00396. SHIGARICIN.
SMARTiSM00458. RICIN. 2 hits.
[Graphical view]
SUPFAMiSSF50370. SSF50370. 2 hits.
SSF56371. SSF56371. 1 hit.
PROSITEiPS50231. RICIN_B_LECTIN. 2 hits.
PS00275. SHIGA_RICIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O22415-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVVTKLLYL VVLAICGLGI HGALTHTRVT PPVYPSVSFN LTGADTYGPF
60 70 80 90 100
LRALQEKVIL GNHTAFDLPV LNPESQVSDS NRFVLVPLTN PSGDTVTLAI
110 120 130 140 150
DVVNLYVVAF SSNGRSYFFS GSTAVQRDNL FVDTTQEELN FTGNYISLER
160 170 180 190 200
QVGFGRVYIP LGPKSLAQAI SSLRTYTLSA GDTKPLARGL LVVIQMVSEA
210 220 230 240 250
ARFRYIELRI RTSITDASEF TPDLLMLSME NNWSSMSSEI QQAQPGGIFP
260 270 280 290 300
GVVQLRDERN NPIEVTNFRR LFELTYIAVL LYGCAPVTSN SYTNNAIDAQ
310 320 330 340 350
IIKMPVFRGG GYEKVCSVVE VTRRISGWDG LCVDVRDGHY IDGNTVQLGP
360 370 380 390 400
CGNECNQLWT FRTDGTIRWL GKCLTTSSSV MIYDCNTVPP EATKWVVSTD
410 420 430 440 450
GTITNPRSGL VLTAPQAAEG TALSLENNIH AARQGWTVGD VEPLVTFIVG
460 470 480 490 500
YKQMCLTENG ENNFVWLEDC VLNRVEQEWA LYGDGTIRVN SNRSLCVTSE
510 520 530 540 550
DHEPSDLIVI LKCEGSGNQR WVFNTNGTIS NPNAKLVMDV AQSNVSLRKI
560 570
ILYPPTGNPN QQWITTTQPA
Length:570
Mass (Da):62,752
Last modified:January 1, 1998 - v1
Checksum:i7D799D3A20764BA6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF012899 mRNA. Translation: AAC49989.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF012899 mRNA. Translation: AAC49989.1 .

3D structure databases

ProteinModelPortali O22415.
SMRi O22415. Positions 33-285, 315-566.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.420.10. 1 hit.
4.10.470.10. 1 hit.
InterProi IPR001574. Ribosome_inactivat_prot.
IPR017988. Ribosome_inactivat_prot_CS.
IPR016138. Ribosome_inactivat_prot_sub1.
IPR016139. Ribosome_inactivat_prot_sub2.
IPR017989. Ribosome_inactivat_prot_subgr.
IPR000772. Ricin_B_lectin.
[Graphical view ]
Pfami PF00652. Ricin_B_lectin. 2 hits.
PF00161. RIP. 1 hit.
[Graphical view ]
PRINTSi PR00396. SHIGARICIN.
SMARTi SM00458. RICIN. 2 hits.
[Graphical view ]
SUPFAMi SSF50370. SSF50370. 2 hits.
SSF56371. SSF56371. 1 hit.
PROSITEi PS50231. RICIN_B_LECTIN. 2 hits.
PS00275. SHIGA_RICIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Elderberry (Sambucus nigra) contains truncated Neu5Ac(alpha-2,6)Gal/GalNAc-binding type 2 ribosome-inactivating proteins."
    Peumans W.J., Roy S., Barre A., Rouge P., van Leuven F., van Damme E.J.
    FEBS Lett. 425:35-39(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: FruitImported.

Entry informationi

Entry nameiO22415_SAMNI
AccessioniPrimary (citable) accession number: O22415
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)