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O22415

- O22415_SAMNI

UniProt

O22415 - O22415_SAMNI

Protein

rRNA N-glycosidase

Gene

LECSNA-If

Organism
Sambucus nigra (European elder)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. rRNA N-glycosylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. defense response Source: UniProtKB-KW
    2. negative regulation of translation Source: UniProtKB-KW

    Keywords - Molecular functioni

    HydrolaseUniRule annotationSAAS annotation, Protein synthesis inhibitorUniRule annotationSAAS annotation, ToxinUniRule annotationSAAS annotation

    Keywords - Biological processi

    Plant defenseUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    rRNA N-glycosidaseUniRule annotation (EC:3.2.2.22UniRule annotation)
    Gene namesi
    Name:LECSNA-IfImported
    OrganismiSambucus nigra (European elder)Imported
    Taxonomic identifieri4202 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsDipsacalesAdoxaceaeSambucus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828 PotentialImportedAdd
    BLAST
    Chaini29 – 570542 PotentialImportedPRO_5000053324Add
    BLAST
    Chaini29 – 308280type 2 ribosome-inactivating protein SNAIf, A chainImportedPRO_5000053325Add
    BLAST
    Chaini309 – 570262type 2 ribosome-inactivating protein SNAIf, B chainImportedPRO_5000053326Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO22415.
    SMRiO22415. Positions 33-285, 315-566.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosome-inactivating protein family.UniRule annotation

    Keywords - Domaini

    SignalImported

    Family and domain databases

    Gene3Di3.40.420.10. 1 hit.
    4.10.470.10. 1 hit.
    InterProiIPR001574. Ribosome_inactivat_prot.
    IPR017988. Ribosome_inactivat_prot_CS.
    IPR016138. Ribosome_inactivat_prot_sub1.
    IPR016139. Ribosome_inactivat_prot_sub2.
    IPR017989. Ribosome_inactivat_prot_subgr.
    IPR000772. Ricin_B_lectin.
    [Graphical view]
    PfamiPF00652. Ricin_B_lectin. 2 hits.
    PF00161. RIP. 1 hit.
    [Graphical view]
    PRINTSiPR00396. SHIGARICIN.
    SMARTiSM00458. RICIN. 2 hits.
    [Graphical view]
    SUPFAMiSSF50370. SSF50370. 2 hits.
    SSF56371. SSF56371. 1 hit.
    PROSITEiPS50231. RICIN_B_LECTIN. 2 hits.
    PS00275. SHIGA_RICIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O22415-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVVTKLLYL VVLAICGLGI HGALTHTRVT PPVYPSVSFN LTGADTYGPF    50
    LRALQEKVIL GNHTAFDLPV LNPESQVSDS NRFVLVPLTN PSGDTVTLAI 100
    DVVNLYVVAF SSNGRSYFFS GSTAVQRDNL FVDTTQEELN FTGNYISLER 150
    QVGFGRVYIP LGPKSLAQAI SSLRTYTLSA GDTKPLARGL LVVIQMVSEA 200
    ARFRYIELRI RTSITDASEF TPDLLMLSME NNWSSMSSEI QQAQPGGIFP 250
    GVVQLRDERN NPIEVTNFRR LFELTYIAVL LYGCAPVTSN SYTNNAIDAQ 300
    IIKMPVFRGG GYEKVCSVVE VTRRISGWDG LCVDVRDGHY IDGNTVQLGP 350
    CGNECNQLWT FRTDGTIRWL GKCLTTSSSV MIYDCNTVPP EATKWVVSTD 400
    GTITNPRSGL VLTAPQAAEG TALSLENNIH AARQGWTVGD VEPLVTFIVG 450
    YKQMCLTENG ENNFVWLEDC VLNRVEQEWA LYGDGTIRVN SNRSLCVTSE 500
    DHEPSDLIVI LKCEGSGNQR WVFNTNGTIS NPNAKLVMDV AQSNVSLRKI 550
    ILYPPTGNPN QQWITTTQPA 570
    Length:570
    Mass (Da):62,752
    Last modified:January 1, 1998 - v1
    Checksum:i7D799D3A20764BA6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF012899 mRNA. Translation: AAC49989.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF012899 mRNA. Translation: AAC49989.1 .

    3D structure databases

    ProteinModelPortali O22415.
    SMRi O22415. Positions 33-285, 315-566.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.420.10. 1 hit.
    4.10.470.10. 1 hit.
    InterProi IPR001574. Ribosome_inactivat_prot.
    IPR017988. Ribosome_inactivat_prot_CS.
    IPR016138. Ribosome_inactivat_prot_sub1.
    IPR016139. Ribosome_inactivat_prot_sub2.
    IPR017989. Ribosome_inactivat_prot_subgr.
    IPR000772. Ricin_B_lectin.
    [Graphical view ]
    Pfami PF00652. Ricin_B_lectin. 2 hits.
    PF00161. RIP. 1 hit.
    [Graphical view ]
    PRINTSi PR00396. SHIGARICIN.
    SMARTi SM00458. RICIN. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50370. SSF50370. 2 hits.
    SSF56371. SSF56371. 1 hit.
    PROSITEi PS50231. RICIN_B_LECTIN. 2 hits.
    PS00275. SHIGA_RICIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Elderberry (Sambucus nigra) contains truncated Neu5Ac(alpha-2,6)Gal/GalNAc-binding type 2 ribosome-inactivating proteins."
      Peumans W.J., Roy S., Barre A., Rouge P., van Leuven F., van Damme E.J.
      FEBS Lett. 425:35-39(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: FruitImported.

    Entry informationi

    Entry nameiO22415_SAMNI
    AccessioniPrimary (citable) accession number: O22415
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 1, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)