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Protein

Heat stress transcription factor B-3

Gene

HSFB3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional regulator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi38 – 132By similarityAdd BLAST95

GO - Molecular functioni

  • sequence-specific DNA binding Source: InterPro
  • transcription factor activity, sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • response to cadmium ion Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Stress response, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-ATH-3371453. Regulation of HSF1-mediated heat shock response.
R-ATH-3371511. HSF1 activation.
R-ATH-3371568. Attenuation phase.
R-ATH-3371571. HSF1-dependent transactivation.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat stress transcription factor B-3
Short name:
AtHsfB3
Alternative name(s):
AtHsf-05
Gene namesi
Name:HSFB3
Synonyms:HSF05
Ordered Locus Names:At2g41690
ORF Names:T32G6.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G41690.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002708121 – 244Heat stress transcription factor B-3Add BLAST244

Post-translational modificationi

Exhibits temperature-dependent phosphorylation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO22230.

Expressioni

Gene expression databases

GenevisibleiO22230. AT.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi3702.AT2G41690.1.

Structurei

3D structure databases

ProteinModelPortaliO22230.
SMRiO22230.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni173 – 218Hydrophobic repeat HR-A/BAdd BLAST46

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi202 – 208Nuclear localization signalSequence analysis7
Motifi236 – 243Nuclear export signalSequence analysis8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi37 – 40Poly-Pro4

Domaini

The hydrophobic-rich region (HR-A/B) corresponds to the oligomerization domain.

Sequence similaritiesi

Belongs to the HSF family. Class B subfamily.Curated

Phylogenomic databases

eggNOGiKOG0627. Eukaryota.
COG5169. LUCA.
HOGENOMiHOG000242480.
InParanoidiO22230.
KOiK09419.
OMAiCKQLMEL.
OrthoDBiEOG09360JWU.
PhylomeDBiO22230.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000232. HSF_DNA-bd.
IPR027725. HSF_fam.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10015. PTHR10015. 2 hits.
PfamiPF00447. HSF_DNA-bind. 1 hit.
[Graphical view]
PRINTSiPR00056. HSFDOMAIN.
SMARTiSM00415. HSF. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00434. HSF_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O22230-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDAGEHLRC NDNVNDEERL PLEFMIGNST STAELQPPPP FLVKTYKVVE
60 70 80 90 100
DPTTDGVISW NEYGTGFVVW QPAEFARDLL PTLFKHCNFS SFVRQLNTYG
110 120 130 140 150
FRKVTTIRWE FSNEMFRKGQ RELMSNIRRR KSQHWSHNKS NHQVVPTTTM
160 170 180 190 200
VNQEGHQRIG IDHHHEDQQS SATSSSFVYT ALLDENKCLK NENELLSCEL
210 220 230 240
GKTKKKCKQL MELVERYRGE DEDATDESDD EEDEGLKLFG VKLE
Length:244
Mass (Da):28,308
Last modified:January 1, 1998 - v1
Checksum:iFC335FFF2705E948
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002510 Genomic DNA. Translation: AAB84350.1.
CP002685 Genomic DNA. Translation: AEC10016.1.
BT029452 mRNA. Translation: ABK59681.1.
PIRiT00825.
RefSeqiNP_181700.1. NM_129732.2.
UniGeneiAt.53095.

Genome annotation databases

EnsemblPlantsiAT2G41690.1; AT2G41690.1; AT2G41690.
GeneIDi818767.
GrameneiAT2G41690.1; AT2G41690.1; AT2G41690.
KEGGiath:AT2G41690.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002510 Genomic DNA. Translation: AAB84350.1.
CP002685 Genomic DNA. Translation: AEC10016.1.
BT029452 mRNA. Translation: ABK59681.1.
PIRiT00825.
RefSeqiNP_181700.1. NM_129732.2.
UniGeneiAt.53095.

3D structure databases

ProteinModelPortaliO22230.
SMRiO22230.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G41690.1.

Proteomic databases

PaxDbiO22230.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G41690.1; AT2G41690.1; AT2G41690.
GeneIDi818767.
GrameneiAT2G41690.1; AT2G41690.1; AT2G41690.
KEGGiath:AT2G41690.

Organism-specific databases

TAIRiAT2G41690.

Phylogenomic databases

eggNOGiKOG0627. Eukaryota.
COG5169. LUCA.
HOGENOMiHOG000242480.
InParanoidiO22230.
KOiK09419.
OMAiCKQLMEL.
OrthoDBiEOG09360JWU.
PhylomeDBiO22230.

Enzyme and pathway databases

ReactomeiR-ATH-3371453. Regulation of HSF1-mediated heat shock response.
R-ATH-3371511. HSF1 activation.
R-ATH-3371568. Attenuation phase.
R-ATH-3371571. HSF1-dependent transactivation.

Miscellaneous databases

PROiO22230.

Gene expression databases

GenevisibleiO22230. AT.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000232. HSF_DNA-bd.
IPR027725. HSF_fam.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10015. PTHR10015. 2 hits.
PfamiPF00447. HSF_DNA-bind. 1 hit.
[Graphical view]
PRINTSiPR00056. HSFDOMAIN.
SMARTiSM00415. HSF. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00434. HSF_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSFB3_ARATH
AccessioniPrimary (citable) accession number: O22230
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.