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Protein

Fasciclin-like arabinogalactan protein 8

Gene

FLA8

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be a cell surface adhesion protein.

Names & Taxonomyi

Protein namesi
Recommended name:
Fasciclin-like arabinogalactan protein 8
Short name:
AtAGP8
Gene namesi
Name:FLA8
Ordered Locus Names:At2g45470
ORF Names:F4L23.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G45470
TAIRilocus:2050822 AT2G45470

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000000878026 – 392Fasciclin-like arabinogalactan protein 8Add BLAST367
PropeptideiPRO_0000008781393 – 420Removed in mature formSequence analysisAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi27N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi273N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi392GPI-anchor amidated asparagine1 Publication1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein, Proteoglycan

Proteomic databases

PaxDbiO22126
PRIDEiO22126

Expressioni

Tissue specificityi

Expressed mainly in flowers and to a lesser extend in leaves and roots.2 Publications

Inductioni

Down-regulated by abscisic acid (ABA).1 Publication

Gene expression databases

ExpressionAtlasiO22126 baseline and differential
GenevisibleiO22126 AT

Interactioni

Protein-protein interaction databases

BioGridi4491, 1 interactor
STRINGi3702.AT2G45470.1

Structurei

3D structure databases

ProteinModelPortaliO22126
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 172FAS1 1PROSITE-ProRule annotationAdd BLAST147
Domaini186 – 326FAS1 2PROSITE-ProRule annotationAdd BLAST141

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi338 – 382Pro-richAdd BLAST45

Sequence similaritiesi

Belongs to the fasciclin-like AGP family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IJMZ Eukaryota
ENOG410YIMZ LUCA
HOGENOMiHOG000240961
InParanoidiO22126
OMAiVKSHNIT
OrthoDBiEOG09360H57
PhylomeDBiO22126

Family and domain databases

Gene3Di2.30.180.10, 2 hits
InterProiView protein in InterPro
IPR036378 FAS1_dom_sf
IPR000782 FAS1_domain
IPR033254 Plant_FLA
PANTHERiPTHR32382 PTHR32382, 1 hit
PfamiView protein in Pfam
PF02469 Fasciclin, 1 hit
SMARTiView protein in SMART
SM00554 FAS1, 1 hit
SUPFAMiSSF82153 SSF82153, 2 hits
PROSITEiView protein in PROSITE
PS50213 FAS1, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O22126-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASQTFSLL AFTFSLLAFA STVSSHNITQ ILADSPDYSS FNSYLSQTKL
60 70 80 90 100
ADEINSRTTI TVLVLNNGAM SALAGKHPLS VIKSALSLLV LLDYYDPQKL
110 120 130 140 150
HKISKGTTLS TTLYQTTGNA PGNLGFVNIT DLKGGKVGFG SAASGSKLDS
160 170 180 190 200
SYTKSVKQIP YNISILEIDA PIIAPGVLTA PAPSASLSNI TGLLEKAGCK
210 220 230 240 250
TFANLLVSSG VLKTYESAVE KGLTVFAPSD EAFKAEGVPD LTKLTQAEVV
260 270 280 290 300
SLLEYHALAE YKPKGSLKTN KNNISTLATN GAGKFDLTTS TSGDEVILHT
310 320 330 340 350
GVAPSRLADT VLDATPVVIF TVDNVLLPAE LFGKSKSPSP APAPEPVTAP
360 370 380 390 400
TPSPADAPSP TAASPPAPPT DESPESAPSD SPTGSANSKS ANAAVGVSTP
410 420
SLFTALVTIA AIAVSVSLCS
Length:420
Mass (Da):43,075
Last modified:January 1, 1998 - v1
Checksum:i0387BEE37881004B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti412I → V (Ref. 4) Curated1
Sequence conflicti412I → V (PubMed:11006345).Curated1
Sequence conflicti412I → V (PubMed:11554470).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002387 Genomic DNA Translation: AAB82617.1
CP002685 Genomic DNA Translation: AEC10559.1
AY094443 mRNA Translation: AAM19815.1
AY149956 mRNA Translation: AAN31110.1
AY088542 mRNA Translation: AAM66074.1
AF195889 mRNA Translation: AAG24276.1
AK220841 mRNA Translation: BAD94169.1
PIRiH84890
RefSeqiNP_566043.1, NM_130109.3
UniGeneiAt.19671
At.69345
At.71483

Genome annotation databases

EnsemblPlantsiAT2G45470.1; AT2G45470.1; AT2G45470
GeneIDi819155
GrameneiAT2G45470.1; AT2G45470.1; AT2G45470
KEGGiath:AT2G45470

Similar proteinsi

Entry informationi

Entry nameiFLA8_ARATH
AccessioniPrimary (citable) accession number: O22126
Secondary accession number(s): Q56ZW9, Q8L9B1, Q9FR46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: January 1, 1998
Last modified: April 25, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health