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Protein

Chalcone synthase D

Gene

CHSD

Organism
Ipomoea nil (Japanese morning glory) (Pharbitis nil)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathway: flavonoid biosynthesis

This protein is involved in the pathway flavonoid biosynthesis, which is part of Secondary metabolite biosynthesis.
View all proteins of this organism that are known to be involved in the pathway flavonoid biosynthesis and in Secondary metabolite biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei164 – 1641PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase D (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase D
Short name:
CHS-D
Gene namesi
Name:CHSD
OrganismiIpomoea nil (Japanese morning glory) (Pharbitis nil)
Taxonomic identifieri35883 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesConvolvulaceaeIpomoeeaeIpomoea

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Chalcone synthase DPRO_0000216037Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO22045.
SMRiO22045. Positions 3-386.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O22045-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTVEEVRKA QRAEGPATIL AIGTATPANC VDQSTYPDYY FRITNSDHMT
60 70 80 90 100
DLKQKFQRMC DKSMITKRYM HLTEEILKEN PSFCEYMAPS LDARQDIVVV
110 120 130 140 150
EVPKLGKEAA QSAIKEWGQP KSKITHVIFC TTSGVDMPGA DYQLTKLLGL
160 170 180 190 200
RPSVKRLMMY QQGCFAGGTV LRVAKDLAEN NKAARVLVVC SEITVVTFRG
210 220 230 240 250
PNETHLDSLV GQALFGDGAA AIIVGSDPTP AEKPLFQLVS AAQTLAPDSC
260 270 280 290 300
GAIDGHLREV GLTFHLLKDV PSIVSNNIEK CLSEAFNPLG ISDWNSIFWI
310 320 330 340 350
AHPGGPAILD QVEDKLGLKP EKLRATRHVL SEYGNMSSAC VLFILDEMRK
360 370 380
ASSNDGLGTT GEGLEWGVLF GFGPGLTIET VVLHSVPA
Length:388
Mass (Da):42,183
Last modified:January 1, 1998 - v1
Checksum:i1BE2CDB2C2DABDEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001818 mRNA. Translation: BAA21787.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001818 mRNA. Translation: BAA21787.1.

3D structure databases

ProteinModelPortaliO22045.
SMRiO22045. Positions 3-386.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00154.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of new chalcone synthase genes for flower pigmentation in the Japanese and common morning glories."
    Fukada-Tanaka S., Hoshino A., Hisatomi Y., Habu Y., Hasebe M., Iida S.
    Plant Cell Physiol. 38:754-758(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. KK/ZSK-2.
    Tissue: Flower bud.

Entry informationi

Entry nameiCHSD_IPONI
AccessioniPrimary (citable) accession number: O22045
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: October 1, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.