Geranylgeranyl pyrophosphate synthetase 6, mitochondrial precursor

Contribute

Send feedback

Read comments (1) or add your own

Reviewed, UniProtKB/Swiss-Prot O22043 (GGPP6_ARATH)

Last modified June 16, 2009. Version 51. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data |

Customize display

text xml rdf/xml gff fasta

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein names

Recommended name:
    Geranylgeranyl pyrophosphate synthetase 6, mitochondrial
      Short name=GGPP synthetase 6
      Short name=GGPS6
Including the following 3 domains:
    1- Recommended name:
            Dimethylallyltranstransferase
              EC=2.5.1.1
    2- Recommended name:
            Geranyltranstransferase
              EC=2.5.1.10
    3- Recommended name:
            Farnesyltranstransferase
              EC=2.5.1.29

Gene names

Name:	GGPP6
Ordered Locus Names:	At1g49530
ORF Names:	F13F21.3

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Hide | Top

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

Hide | Top

General annotation (Comments)

Function	Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate.
Catalytic activity	Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate. Trans,trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.
Pathway	Isoprenoid biosynthesis; farnesyl-PP biosynthesis; farnesyl-PP from geranyl-PP and isopentenyl-PP: step 1/1. Isoprenoid biosynthesis; geranyl-PP biosynthesis; geranyl-PP from dimethylallyl-PP and isopentenyl-PP: step 1/1. Isoprenoid biosynthesis; geranylgeranyl-PP biosynthesis; geranylgeranyl-PP from farnesyl-PP and isopentenyl-PP: step 1/1.
Subunit structure	Monomer By similarity.
Subcellular location	Mitochondrion. Ref.1 Ref.2
Sequence similarities	Belongs to the FPP/GGPP synthetase family.

Hide | Top

Ontologies

Keywords
Biological process	Carotenoid biosynthesis Isoprene biosynthesis
Cellular component	Mitochondrion
Domain	Transit peptide
Molecular function	Transferase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological process	carotenoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Ref.2 Inferred from direct assay. Source: TAIR
Molecular function	dimethylallyltranstransferase activity Inferred from electronic annotation. Source: EC farnesyltranstransferase activity Ref.1 Inferred from direct assay. Source: TAIR geranyltranstransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Transit peptide

1 – 22

Mitochondrion Potential

Chain

23 – 336

314

Geranylgeranyl pyrophosphate synthetase 6, mitochondrial

PRO_0000045405

Experimental info

Sequence conflict

M → MLCKIIIM Ref.1

Sequence conflict

M → MLCKIIIM Ref.2

Sequence conflict

R → C Ref.1

Sequence conflict

R → C Ref.2

Sequence conflict

I → V Ref.1

Sequence conflict

I → V Ref.2

Sequence conflict

K → N Ref.1

Sequence conflict

K → N Ref.2

Sequence conflict

F → S Ref.1

Sequence conflict

F → S Ref.2

Sequence conflict

P → S Ref.1

Sequence conflict

P → S Ref.2

Sequence conflict

133

K → I Ref.1

Sequence conflict

133

K → I Ref.2

Sequence conflict

153

R → M Ref.1

Sequence conflict

153

R → M Ref.2

Hide | Top

Sequences

Sequence

Length

Mass (Da)

Tools

O22043-1 [UniParc].

Last modified January 10, 2006. Version 2.
Checksum: 95F32D360003C954
Show »

FASTA

336

36,886

        10         20         30         40         50         60 
MRPRYSLILS AMRLIRPSNR RLSSIASSDS EFISYMKNKA KSINKALDNS IPLCNNFVPL 

        70         80         90        100        110        120 
WEPVLEVHKA MRYTLLPGGK RVRPMLCLVA CELVGGQEST AMPAACAVEM IHAASLILDD 

       130        140        150        160        170        180 
LPCMDDDSLR RGKPTNHKVF GEKTSILASN ALRSLAVKQT LASTSLGVTS ERVLRAVQEM 

       190        200        210        220        230        240 
ARAVGTEGLV AGQAADLAGE RMSFKNEDDE LRYLELMHVH KTAVLVEAAA VVGAIMGGGS 

       250        260        270        280        290        300 
DEEIERLKSY ARCVGLMFQV MDDVLDETKS SEELGKTAGK DLITGKLTYP KVMGVDNARE 

       310        320        330 
YAKRLNREAQ EHLQGFDSDK VVPLLSLADY IVKRQN

« Hide

Hide | Top

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Geranylgeranyl pyrophosphate synthase encoded by the newly isolated gene GGPS6 from Arabidopsis thaliana is localized in mitochondria." Zhu X., Suzuki K., Saito T., Okada K., Tanaka K., Nakagawa T., Matsuda H., Kawamukai M. Plant Mol. Biol. 35:331-341(1997) [PubMed: 9349257] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION. Strain: cv. Landsberg erecta.
[2]	"Five geranylgeranyl diphosphate synthases expressed in different organs are localized into three subcellular compartments in Arabidopsis." Okada K., Saito T., Nakagawa T., Kawamukai M., Kamiya Y. Plant Physiol. 122:1045-1056(2000) [PubMed: 10759500] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
[3]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. Davis R.W. Nature 408:816-820(2000) [PubMed: 11130712] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[4]	Kim C.J., Chen H., Cheuk R.F., Shinn P., Ecker J.R. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Hide | Top

Cross-references

Sequence databases
	AB000835 Genomic DNA. Translation: BAA23157.1. AC007504 Genomic DNA. Translation: AAD43148.1. BT011230 mRNA. Translation: AAR92266.1. BT012158 mRNA. Translation: AAS76253.1.
IPI	IPI00537288.
RefSeq	NP_175376.1.
UniGene	At.38214
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	841377.
GenomeReviews	Gene locus AT1G49530 in contig CT485782_GR.
KEGG	ath:AT1G49530.
NMPDR	fig\|3702.1.peg.4426.
Organism-specific databases
TAIR	At1g49530.
Enzyme and pathway databases
BRENDA	2.5.1.1. 302. 2.5.1.10. 302. 2.5.1.29. 302.
Gene expression databases
GermOnline	AT1G49530. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR000092. Polyprenyl_synt. IPR017446. Polyprenyl_synth-rel. IPR008949. Terpenoid_synth. [Graphical view]
Gene3D	G3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
PANTHER	PTHR12001. Polyprenyl_synt. 1 hit.
Pfam	PF00348. polyprenyl_synt. 1 hit. [Graphical view]
PROSITE	PS00723. POLYPRENYL_SYNTHET_1. 1 hit. PS00444. POLYPRENYL_SYNTHET_2. 1 hit. [Graphical view]
ProtoNet	Search...

Hide | Top

Entry information

Entry name

GGPP6_ARATH

Accession

Primary (citable) accession number: O22043
Secondary accession number(s): Q9XIC0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	January 10, 2006
Last modified:	June 16, 2009
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)

Hide | Top

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents