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Protein

Deoxycytidylate deaminase

Gene

36.1

Organism
Mycobacterium phage D29 (Mycobacteriophage D29)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

dCMP + H2O = dUMP + NH3.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi81 – 811Zinc; catalyticBy similarity
Active sitei83 – 831Proton donorBy similarity
Metal bindingi107 – 1071Zinc; catalyticBy similarity
Metal bindingi110 – 1101Zinc; catalyticBy similarity

GO - Molecular functioni

  1. dCMP deaminase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. nucleotide biosynthetic process Source: UniProtKB-KW
  2. pyrimidine nucleotide metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxycytidylate deaminase (EC:3.5.4.12)
Alternative name(s):
dCMP deaminase
Gene namesi
Name:36.1
Synonyms:G1
OrganismiMycobacterium phage D29 (Mycobacteriophage D29)
Taxonomic identifieri28369 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeL5likevirus
Virus hostiMycobacterium [TaxID: 1763]
ProteomesiUP000002131: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 128128Deoxycytidylate deaminasePRO_0000171698Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO22000.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR016473. dCMP_deaminase.
IPR015517. dCMP_deaminase-rel.
[Graphical view]
PANTHERiPTHR11086. PTHR11086. 1 hit.
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
PIRSFiPIRSF006019. dCMP_deaminase. 1 hit.
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O22000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRPDWDEYF LGIATAAAQR SDCERSKVGA VVVKDRRVRG TGYNGAPAGA
60 70 80 90 100
AGCSTCPRRL SGAVPGVSDY SSGATRCVAV HAEANALLYC DREDLIGATL
110 120
YVTREPCYAC SNLIAASGIE RVVYPKES
Length:128
Mass (Da):13,539
Last modified:December 15, 1998 - v2
Checksum:iF78F1BA3DB5184D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022214 Genomic DNA. Translation: AAC18478.1.
U81553 Genomic DNA. Translation: AAB69099.1.
PIRiC72804.
RefSeqiNP_046853.1. NC_001900.1.

Genome annotation databases

GeneIDi1261565.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022214 Genomic DNA. Translation: AAC18478.1.
U81553 Genomic DNA. Translation: AAB69099.1.
PIRiC72804.
RefSeqiNP_046853.1. NC_001900.1.

3D structure databases

ProteinModelPortaliO22000.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1261565.

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR016473. dCMP_deaminase.
IPR015517. dCMP_deaminase-rel.
[Graphical view]
PANTHERiPTHR11086. PTHR11086. 1 hit.
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
PIRSFiPIRSF006019. dCMP_deaminase. 1 hit.
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome structure of mycobacteriophage D29: implications for phage evolution."
    Ford M.E., Sarkis G.J., Belanger A.E., Hendrix R.W., Hatfull G.F.
    J. Mol. Biol. 279:143-164(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Mycobacteriophage D29 contains an integration system similar to that of the temperate mycobacteriophage L5."
    Ribeiro G., Viveiros M., David H.L., Costa J.V.
    Microbiology 143:2701-2708(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 51-128.

Entry informationi

Entry nameiDCTD_BPMD2
AccessioniPrimary (citable) accession number: O22000
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: January 7, 2015
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.