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O21521 (NU4M_MICPE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase chain 4

EC=1.6.5.3
Alternative name(s):
NADH dehydrogenase subunit 4
Gene names
Name:MT-ND4
Synonyms:MTND4, NADH4, ND4
Encoded onMitochondrion
OrganismMicrotus pennsylvanicus (Meadow vole)
Taxonomic identifier10058 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeArvicolinaeMicrotus

Protein attributes

Sequence length208 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the complex I subunit 4 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›208›208NADH-ubiquinone oxidoreductase chain 4
PRO_0000117955

Regions

Transmembrane23 – 4321Helical; Potential
Transmembrane60 – 8021Helical; Potential
Transmembrane93 – 11321Helical; Potential
Transmembrane114 – 13421Helical; Potential
Transmembrane147 – 16721Helical; Potential
Transmembrane185 – 20521Helical; Potential

Experimental info

Non-terminal residue2081

Sequences

Sequence LengthMass (Da)Tools
O21521 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 8769CF4EED5DF42E

FASTA20823,921
        10         20         30         40         50         60 
MLKIIFPSFM LLPLTWLSSN KKVWINVTTY SLLINLISIN LLWQNNENNL SFSTMFSADP 

        70         80         90        100        110        120 
LSAPLLVLTT WLLPLMLLAS QNHIKKESEH NKKLYISLLV CLQTLLIMTF SANELIMFYI 

       130        140        150        160        170        180 
LFEATLIPTL IIITRWGNQT ERLNAGIYFL FYTLVGSIPL LIALIYIQNW TGTLNLILMT 

       190        200 
LDSSPINQTW SNNILWLACI MAFMVKMP 

« Hide

References

[1]"Molecular systematics and paleobiogeography of the South American sigmodontine rodents."
Engel S.R., Hogan K.M., Taylor J.F., Davis S.K.
Mol. Biol. Evol. 15:35-49(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U83806 Genomic DNA. Translation: AAB87186.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSPR01437. NUOXDRDTASE4.
ProtoNetSearch...

Entry information

Entry nameNU4M_MICPE
AccessionPrimary (citable) accession number: O21521
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families