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O21406 (NU4M_STRCA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase chain 4

EC=1.6.5.3
Alternative name(s):
NADH dehydrogenase subunit 4
Gene names
Name:MT-ND4
Synonyms:MTND4, NADH4, ND4
Encoded onMitochondrion
OrganismStruthio camelus (Ostrich)
Taxonomic identifier8801 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesPalaeognathaeStruthioniformesStruthionidaeStruthio

Protein attributes

Sequence length458 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the complex I subunit 4 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 458458NADH-ubiquinone oxidoreductase chain 4
PRO_0000117990

Regions

Transmembrane21 – 4323Helical; Potential
Transmembrane58 – 7821Helical; Potential
Transmembrane93 – 11220Helical; Potential
Transmembrane116 – 13823Helical; Potential
Transmembrane145 – 16521Helical; Potential
Transmembrane196 – 21621Helical; Potential
Transmembrane224 – 24421Helical; Potential
Transmembrane257 – 27721Helical; Potential
Transmembrane285 – 30521Helical; Potential
Transmembrane309 – 32921Helical; Potential
Transmembrane341 – 36121Helical; Potential
Transmembrane379 – 39921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
O21406 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 575118B6297A18AC

FASTA45850,955
        10         20         30         40         50         60 
MLKIIIPTIM LLPTALLSPK ASLWTNTTTY SLLIATISLQ WLNPTYFPHK NMTPWTGIDQ 

        70         80         90        100        110        120 
ISAPLLVLSC WLLPLMLLAS QNHLQQEPLV RKRTFIVTLT TIQPFIILAF SATELTLFYI 

       130        140        150        160        170        180 
SFEATLIPTL ILITRWGNQP ERLSAGIYLL FYTLISSLPL LVTILHLHTQ IGTLHMPTLE 

       190        200        210        220        230        240 
LTHPLLTHSW TGTLSGLALL MAFMVKAPLY GLHLWLPKAH VEAPIAGSML LAALLLKLGG 

       250        260        270        280        290        300 
YGIMRVTLLM GPLTDRLSYP FLALALWGAL MTSSICLRQT DLKSLIAYSS VSHMGLVIAA 

       310        320        330        340        350        360 
SMIQTDWSFS GAMILMISHG LTSSMLFCLA NTNYERTHSR ILLLTRGLQP LLPLMSVWWL 

       370        380        390        400        410        420 
LANLTNMALP PTTNLMAELT IMIALFNWST PTIILTGLAT LLTASYTLFM LSMTQRGTLP 

       430        440        450 
THLTSIHNSN TREHLLMTLH IFPMLLLMLK PELISGVI 

« Hide

References

[1]"The mtDNA sequence of the ostrich and the divergence between paleognathous and neognathous birds."
Harlid A., Janke A., Arnason U.
Mol. Biol. Evol. 14:754-761(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete mitochondrial DNA genome sequences of extinct birds: ratite phylogenetics and the vicariance biogeography hypothesis."
Haddrath O., Baker A.J.
Proc. R. Soc. B 268:939-945(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y12025 Genomic DNA. Translation: CAA72753.1.
AF338715 Genomic DNA. Translation: AAK53354.1.
PIRB99613.
T11528.
RefSeqNP_115450.1. NC_002785.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID803272.

Organism-specific databases

CTD4538.

Phylogenomic databases

HOVERGENHBG093667.

Family and domain databases

InterProIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSPR01437. NUOXDRDTASE4.
TIGRFAMsTIGR01972. NDH_I_M. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNU4M_STRCA
AccessionPrimary (citable) accession number: O21406
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families