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Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

MT-ND4

Organism
Struthio camelus (Common ostrich)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4
Gene namesi
Name:MT-ND4
Synonyms:MTND4, NADH4, ND4
Encoded oniMitochondrion
OrganismiStruthio camelus (Common ostrich)
Taxonomic identifieri8801 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesPalaeognathaeStruthioniformesStruthionidaeStruthio

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4323HelicalSequence AnalysisAdd
BLAST
Transmembranei58 – 7821HelicalSequence AnalysisAdd
BLAST
Transmembranei93 – 11220HelicalSequence AnalysisAdd
BLAST
Transmembranei116 – 13823HelicalSequence AnalysisAdd
BLAST
Transmembranei145 – 16521HelicalSequence AnalysisAdd
BLAST
Transmembranei196 – 21621HelicalSequence AnalysisAdd
BLAST
Transmembranei224 – 24421HelicalSequence AnalysisAdd
BLAST
Transmembranei257 – 27721HelicalSequence AnalysisAdd
BLAST
Transmembranei285 – 30521HelicalSequence AnalysisAdd
BLAST
Transmembranei309 – 32921HelicalSequence AnalysisAdd
BLAST
Transmembranei341 – 36121HelicalSequence AnalysisAdd
BLAST
Transmembranei379 – 39921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 458458NADH-ubiquinone oxidoreductase chain 4PRO_0000117990Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG093667.

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

O21406-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKIIIPTIM LLPTALLSPK ASLWTNTTTY SLLIATISLQ WLNPTYFPHK
60 70 80 90 100
NMTPWTGIDQ ISAPLLVLSC WLLPLMLLAS QNHLQQEPLV RKRTFIVTLT
110 120 130 140 150
TIQPFIILAF SATELTLFYI SFEATLIPTL ILITRWGNQP ERLSAGIYLL
160 170 180 190 200
FYTLISSLPL LVTILHLHTQ IGTLHMPTLE LTHPLLTHSW TGTLSGLALL
210 220 230 240 250
MAFMVKAPLY GLHLWLPKAH VEAPIAGSML LAALLLKLGG YGIMRVTLLM
260 270 280 290 300
GPLTDRLSYP FLALALWGAL MTSSICLRQT DLKSLIAYSS VSHMGLVIAA
310 320 330 340 350
SMIQTDWSFS GAMILMISHG LTSSMLFCLA NTNYERTHSR ILLLTRGLQP
360 370 380 390 400
LLPLMSVWWL LANLTNMALP PTTNLMAELT IMIALFNWST PTIILTGLAT
410 420 430 440 450
LLTASYTLFM LSMTQRGTLP THLTSIHNSN TREHLLMTLH IFPMLLLMLK

PELISGVI
Length:458
Mass (Da):50,955
Last modified:January 1, 1998 - v1
Checksum:i575118B6297A18AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12025 Genomic DNA. Translation: CAA72753.1.
AF338715 Genomic DNA. Translation: AAK53354.1.
PIRiB99613.
T11528.
RefSeqiNP_115450.1. NC_002785.1.

Genome annotation databases

GeneIDi803272.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12025 Genomic DNA. Translation: CAA72753.1.
AF338715 Genomic DNA. Translation: AAK53354.1.
PIRiB99613.
T11528.
RefSeqiNP_115450.1. NC_002785.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi803272.

Organism-specific databases

CTDi4538.

Phylogenomic databases

HOVERGENiHBG093667.

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The mtDNA sequence of the ostrich and the divergence between paleognathous and neognathous birds."
    Harlid A., Janke A., Arnason U.
    Mol. Biol. Evol. 14:754-761(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete mitochondrial DNA genome sequences of extinct birds: ratite phylogenetics and the vicariance biogeography hypothesis."
    Haddrath O., Baker A.J.
    Proc. R. Soc. B 268:939-945(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiNU4M_STRCA
AccessioniPrimary (citable) accession number: O21406
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: April 1, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.