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O21403 (COX3_STRCA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3
EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene names
Name:MT-CO3
Synonyms:COIII, COXIII, MTCO3
Encoded onMitochondrion
OrganismStruthio camelus (Ostrich)
Taxonomic identifier8801 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Palaeognathae › Struthioniformes › Struthionidae › Struthio

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
   Cellular componentMembrane
Mitochondrion
Mitochondrion inner membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processaerobic electron transport chain

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrial inner membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncytochrome-c oxidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Cytochrome c oxidase subunit 3
PRO_0000183857

Regions

Transmembrane15 – 3521Helical; Potential
Transmembrane38 – 5821Helical; Potential
Transmembrane82 – 10221Helical; Potential
Transmembrane127 – 14721Helical; Potential
Transmembrane159 – 17921Helical; Potential
Transmembrane197 – 21721Helical; Potential
Transmembrane239 – 25921Helical; Potential

Experimental info

Sequence conflict551I → V in CAA72750. Ref.1
Sequence conflict1071A → P in CAA72750. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O21403 [UniParc].

Last modified March 27, 2002. Version 2.
Checksum: FD9CFE26D44EAAF6

FASTA26129,759
        10         20         30         40         50         60 
MAHQAHSYHM VDPSPWPIFG ATAALLTTSG LIMWFHYNSL YLLTLGLLSM FLVMIQWWRD 

        70         80         90        100        110        120 
IVRESTFQGH HTPTVQKGLR YGMILFITSE AFFFLGFFWA FFHSSLAPTP ELGAQWPPTG 

       130        140        150        160        170        180 
INPLNPLEVP LLNTAILLAS GVTVTWAHHS ITESNRKQAI HALSLTIILG FYFTALQAME 

       190        200        210        220        230        240 
YHEASFSIAD GVYGSTFFVA TGFHGLHVII GSSFLTVCLL RLIKFHFTTN HHFGFEAAAW 

       250        260 
YWHFVDVIWL FLYMSIYWWG S

« Hide

References

[1]"The mtDNA sequence of the ostrich and the divergence between paleognathous and neognathous birds."
Harlid A., Janke A., Arnason U.
Mol. Biol. Evol. 14:754-761(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete mitochondrial DNA genome sequences of extinct birds: ratite phylogenetics and the vicariance biogeography hypothesis."
Haddrath O., Baker A.J.
Proc. R. Soc. B 268:939-945(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Y12025 Genomic DNA. Translation: CAA72750.1.
AF338715 Genomic DNA. Translation: AAK53349.1.
PIRG90612.
T11525.
RefSeqNP_115447.1. NC_002785.1.

3D structure databases

ProteinModelPortalO21403.
SMRO21403. Positions 1-261.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID803270.

Organism-specific databases

CTD4514.

Phylogenomic databases

HOVERGENHBG016686.

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMSSF81452. CytC_oxdse_III. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX3_STRCA
AccessionPrimary (citable) accession number: O21403
Secondary accession number(s): Q957X5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: March 27, 2002
Last modified: April 3, 2013
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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