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O21403

- COX3_STRCA

UniProt

O21403 - COX3_STRCA

Protein

Cytochrome c oxidase subunit 3

Gene

MT-CO3

Organism
Struthio camelus (Ostrich)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 2 (27 Mar 2002)
      Previous versions | rss
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    Functioni

    Subunits I, II and III form the functional core of the enzyme complex.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. aerobic electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide III
    Gene namesi
    Name:MT-CO3
    Synonyms:COIII, COXIII, MTCO3
    Encoded oniMitochondrion
    OrganismiStruthio camelus (Ostrich)
    Taxonomic identifieri8801 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesPalaeognathaeStruthioniformesStruthionidaeStruthio

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain complex IV Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 261261Cytochrome c oxidase subunit 3PRO_0000183857Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO21403.
    SMRiO21403. Positions 1-261.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei15 – 3521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei38 – 5821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei127 – 14721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG016686.

    Family and domain databases

    Gene3Di1.20.120.80. 1 hit.
    InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view]
    PANTHERiPTHR11403. PTHR11403. 1 hit.
    PfamiPF00510. COX3. 1 hit.
    [Graphical view]
    SUPFAMiSSF81452. SSF81452. 1 hit.
    PROSITEiPS50253. COX3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O21403-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHQAHSYHM VDPSPWPIFG ATAALLTTSG LIMWFHYNSL YLLTLGLLSM    50
    FLVMIQWWRD IVRESTFQGH HTPTVQKGLR YGMILFITSE AFFFLGFFWA 100
    FFHSSLAPTP ELGAQWPPTG INPLNPLEVP LLNTAILLAS GVTVTWAHHS 150
    ITESNRKQAI HALSLTIILG FYFTALQAME YHEASFSIAD GVYGSTFFVA 200
    TGFHGLHVII GSSFLTVCLL RLIKFHFTTN HHFGFEAAAW YWHFVDVIWL 250
    FLYMSIYWWG S 261
    Length:261
    Mass (Da):29,759
    Last modified:March 27, 2002 - v2
    Checksum:iFD9CFE26D44EAAF6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti55 – 551I → V in CAA72750. (PubMed:9214748)Curated
    Sequence conflicti107 – 1071A → P in CAA72750. (PubMed:9214748)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12025 Genomic DNA. Translation: CAA72750.1.
    AF338715 Genomic DNA. Translation: AAK53349.1.
    PIRiG90612.
    T11525.
    RefSeqiNP_115447.1. NC_002785.1.

    Genome annotation databases

    GeneIDi803270.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12025 Genomic DNA. Translation: CAA72750.1 .
    AF338715 Genomic DNA. Translation: AAK53349.1 .
    PIRi G90612.
    T11525.
    RefSeqi NP_115447.1. NC_002785.1.

    3D structure databases

    ProteinModelPortali O21403.
    SMRi O21403. Positions 1-261.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 803270.

    Organism-specific databases

    CTDi 4514.

    Phylogenomic databases

    HOVERGENi HBG016686.

    Family and domain databases

    Gene3Di 1.20.120.80. 1 hit.
    InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view ]
    PANTHERi PTHR11403. PTHR11403. 1 hit.
    Pfami PF00510. COX3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81452. SSF81452. 1 hit.
    PROSITEi PS50253. COX3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mtDNA sequence of the ostrich and the divergence between paleognathous and neognathous birds."
      Harlid A., Janke A., Arnason U.
      Mol. Biol. Evol. 14:754-761(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete mitochondrial DNA genome sequences of extinct birds: ratite phylogenetics and the vicariance biogeography hypothesis."
      Haddrath O., Baker A.J.
      Proc. R. Soc. B 268:939-945(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCOX3_STRCA
    AccessioniPrimary (citable) accession number: O21403
    Secondary accession number(s): Q957X5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: March 27, 2002
    Last modified: October 1, 2014
    This is version 82 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3