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O21400

- COX2_STRCA

UniProt

O21400 - COX2_STRCA

Protein

Cytochrome c oxidase subunit 2

Gene

MT-CO2

Organism
Struthio camelus (Ostrich)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi160 – 1601Copper ACurated
    Metal bindingi195 – 1951Copper ACurated
    Metal bindingi199 – 1991Copper ACurated
    Metal bindingi203 – 2031Copper ACurated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:MT-CO2
    Synonyms:COII, COXII, MTCO2
    Encoded oniMitochondrion
    OrganismiStruthio camelus (Ostrich)
    Taxonomic identifieri8801 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesPalaeognathaeStruthioniformesStruthionidaeStruthio

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain complex IV Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 229229Cytochrome c oxidase subunit 2PRO_0000183696Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO21400.
    SMRiO21400. Positions 1-223.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini48 – 6114Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini82 – 229148Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei62 – 8120HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG012727.

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O21400-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANPSQFGFQ DASSPIMEEL VEFHDHALMV ALAICSLVLY LLALMLVEKL    50
    SSNTVDAQEV ELIWTILPAI VLILLALPSL QILYMMDEID EPDLTLKAIG 100
    HQWYWSYEYT DFKDLTFDSY MIPTSELPPG HFRLLEVDHR VVVPMESPIR 150
    VIITAGDVLH SWAVPTLGVK TDAIPGRLNQ TSFITTRPGI FYGQCSEICG 200
    ANHSYMPIVV ESTPLTYFES WSSLLSTDS 229
    Length:229
    Mass (Da):25,700
    Last modified:January 1, 1998 - v1
    Checksum:iB9377617BACB14EF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12025 Genomic DNA. Translation: CAA72747.1.
    AF069429 Genomic DNA. Translation: AAD09386.1.
    AF338715 Genomic DNA. Translation: AAK53348.1.
    U76069 Genomic DNA. Translation: AAB61329.1. Different termination.
    PIRiD90612.
    T12412.
    RefSeqiNP_115444.1. NC_002785.1.

    Genome annotation databases

    GeneIDi803280.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12025 Genomic DNA. Translation: CAA72747.1 .
    AF069429 Genomic DNA. Translation: AAD09386.1 .
    AF338715 Genomic DNA. Translation: AAK53348.1 .
    U76069 Genomic DNA. Translation: AAB61329.1 . Different termination.
    PIRi D90612.
    T12412.
    RefSeqi NP_115444.1. NC_002785.1.

    3D structure databases

    ProteinModelPortali O21400.
    SMRi O21400. Positions 1-223.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 803280.

    Organism-specific databases

    CTDi 4513.

    Phylogenomic databases

    HOVERGENi HBG012727.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mtDNA sequence of the ostrich and the divergence between paleognathous and neognathous birds."
      Harlid A., Janke A., Arnason U.
      Mol. Biol. Evol. 14:754-761(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Primers for a PCR-based approach to complete mitochondrial genome sequencing."
      Sorenson M.D., Dimcheff D.E., Ast J.C., Yuri T., Mindell D.P.
      Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete mitochondrial DNA genome sequences of extinct birds: ratite phylogenetics and the vicariance biogeography hypothesis."
      Haddrath O., Baker A.J.
      Proc. R. Soc. B 268:939-945(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Phylogenetic relationships of the ratite birds: resolving conflicts between molecular and morphological data sets."
      Lee K., Feinstein J., Cracraft J.
      (In) Mindell D.P. (eds.); Avian molecular evolution and systematics, pp.1-1, Academic Press, New York (1997)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-229.

    Entry informationi

    Entry nameiCOX2_STRCA
    AccessioniPrimary (citable) accession number: O21400
    Secondary accession number(s): O03894
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3