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O21400

- COX2_STRCA

UniProt

O21400 - COX2_STRCA

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Protein
Cytochrome c oxidase subunit 2
Gene
MT-CO2, COII, COXII, MTCO2
Organism
Struthio camelus (Ostrich)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi160 – 1601Copper A Inferred
Metal bindingi195 – 1951Copper A Inferred
Metal bindingi199 – 1991Copper A Inferred
Metal bindingi203 – 2031Copper A Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:MT-CO2
Synonyms:COII, COXII, MTCO2
Encoded oniMitochondrion
OrganismiStruthio camelus (Ostrich)
Taxonomic identifieri8801 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesPalaeognathaeStruthioniformesStruthionidaeStruthio

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei27 – 4721Helical; Reviewed prediction
Add
BLAST
Topological domaini48 – 6114Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei62 – 8120Helical; Reviewed prediction
Add
BLAST
Topological domaini82 – 229148Mitochondrial intermembrane Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Cytochrome c oxidase subunit 2
PRO_0000183696Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO21400.
SMRiO21400. Positions 1-223.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG012727.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O21400-1 [UniParc]FASTAAdd to Basket

« Hide

MANPSQFGFQ DASSPIMEEL VEFHDHALMV ALAICSLVLY LLALMLVEKL    50
SSNTVDAQEV ELIWTILPAI VLILLALPSL QILYMMDEID EPDLTLKAIG 100
HQWYWSYEYT DFKDLTFDSY MIPTSELPPG HFRLLEVDHR VVVPMESPIR 150
VIITAGDVLH SWAVPTLGVK TDAIPGRLNQ TSFITTRPGI FYGQCSEICG 200
ANHSYMPIVV ESTPLTYFES WSSLLSTDS 229
Length:229
Mass (Da):25,700
Last modified:January 1, 1998 - v1
Checksum:iB9377617BACB14EF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y12025 Genomic DNA. Translation: CAA72747.1.
AF069429 Genomic DNA. Translation: AAD09386.1.
AF338715 Genomic DNA. Translation: AAK53348.1.
U76069 Genomic DNA. Translation: AAB61329.1. Different termination.
PIRiD90612.
T12412.
RefSeqiNP_115444.1. NC_002785.1.

Genome annotation databases

GeneIDi803280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y12025 Genomic DNA. Translation: CAA72747.1 .
AF069429 Genomic DNA. Translation: AAD09386.1 .
AF338715 Genomic DNA. Translation: AAK53348.1 .
U76069 Genomic DNA. Translation: AAB61329.1 . Different termination.
PIRi D90612.
T12412.
RefSeqi NP_115444.1. NC_002785.1.

3D structure databases

ProteinModelPortali O21400.
SMRi O21400. Positions 1-223.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 803280.

Organism-specific databases

CTDi 4513.

Phylogenomic databases

HOVERGENi HBG012727.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The mtDNA sequence of the ostrich and the divergence between paleognathous and neognathous birds."
    Harlid A., Janke A., Arnason U.
    Mol. Biol. Evol. 14:754-761(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Primers for a PCR-based approach to complete mitochondrial genome sequencing."
    Sorenson M.D., Dimcheff D.E., Ast J.C., Yuri T., Mindell D.P.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete mitochondrial DNA genome sequences of extinct birds: ratite phylogenetics and the vicariance biogeography hypothesis."
    Haddrath O., Baker A.J.
    Proc. R. Soc. B 268:939-945(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Phylogenetic relationships of the ratite birds: resolving conflicts between molecular and morphological data sets."
    Lee K., Feinstein J., Cracraft J.
    (In) Mindell D.P. (eds.); Avian molecular evolution and systematics, pp.1-1, Academic Press, New York (1997)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-229.

Entry informationi

Entry nameiCOX2_STRCA
AccessioniPrimary (citable) accession number: O21400
Secondary accession number(s): O03894
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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