Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O21399

- COX1_STRCA

UniProt

O21399 - COX1_STRCA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cytochrome c oxidase subunit 1

Gene

MT-CO1

Organism
Struthio camelus (Ostrich)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi62 – 621Iron (heme A axial ligand)Curated
Metal bindingi241 – 2411Copper BCurated
Metal bindingi245 – 2451Copper BCurated
Metal bindingi291 – 2911Copper BCurated
Metal bindingi292 – 2921Copper BCurated
Metal bindingi377 – 3771Iron (heme A3 axial ligand)Curated
Metal bindingi379 – 3791Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:MT-CO1
Synonyms:COI, COXI, MTCO1
Encoded oniMitochondrion
OrganismiStruthio camelus (Ostrich)
Taxonomic identifieri8801 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesPalaeognathaeStruthioniformesStruthionidaeStruthio

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 516516Cytochrome c oxidase subunit 1PRO_0000183422Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki241 ↔ 2451'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliO21399.
SMRiO21399. Positions 3-515.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821HelicalSequence AnalysisAdd
BLAST
Transmembranei57 – 7721HelicalSequence AnalysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST
Transmembranei146 – 16621HelicalSequence AnalysisAdd
BLAST
Transmembranei184 – 20421HelicalSequence AnalysisAdd
BLAST
Transmembranei235 – 25521HelicalSequence AnalysisAdd
BLAST
Transmembranei269 – 28921HelicalSequence AnalysisAdd
BLAST
Transmembranei311 – 33121HelicalSequence AnalysisAdd
BLAST
Transmembranei339 – 35921HelicalSequence AnalysisAdd
BLAST
Transmembranei381 – 40121HelicalSequence AnalysisAdd
BLAST
Transmembranei415 – 43521HelicalSequence AnalysisAdd
BLAST
Transmembranei457 – 47721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG003841.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O21399-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTFITRWLFS TNHKDIGTLY LIFGAWAGMV GTALSLLIRA ELGQPGTLLG
60 70 80 90 100
DDQIYNVIVT AHAFVMIFFM VMPVMIGGFG NWLVPLMIGA PDMAFPRMNN
110 120 130 140 150
MSFWLLPPSF LLLLASSTVE AGAGTGWTVY PPLAGNLAHA GASVDLAIFS
160 170 180 190 200
LHLAGVSSIL GAINFITTAI NMKPPALSQY QTPLFVWSVL ITAILLLLSL
210 220 230 240 250
PVLAAGITML LTDRNLNTTF FDPAGGGDPV LYQHLFWFFG HPEVYILILP
260 270 280 290 300
GFGIISHVVT YYAGKKEPFG YMGMVWAMLS IGFLGFIVWA HHMFTVGMDV
310 320 330 340 350
DTRAYFTSAT MIIAIPTGIK VFSWLATLHG GTIKWDPPIL WALGFIFLFT
360 370 380 390 400
IGGLTGIVLA NSSLDIALHD TYYVVAHFHY VLSMGAVFAI LAGFTHWFPL
410 420 430 440 450
FTGYTLHPTW AKAHFGVMFT GVNLTFFPQH FLGLAGMPRR YSDYPDAYTL
460 470 480 490 500
WNTMSSIGSL ISMTAVIMLM FIIWEAFSSK RKVLQPELIA TNIEWIHGCP
510
PPHHTFEEPA FVQVQE
Length:516
Mass (Da):56,932
Last modified:December 15, 1998 - v2
Checksum:i33FFEC4806D80856
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y12025 Genomic DNA. Translation: CAA72746.1.
AF069429 Genomic DNA. Translation: AAD09385.1.
AF338715 Genomic DNA. Translation: AAK53347.1.
U76062 Genomic DNA. Translation: AAB61328.1.
PIRiC90612.
T12411.
RefSeqiNP_115443.1. NC_002785.1.

Genome annotation databases

GeneIDi803279.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y12025 Genomic DNA. Translation: CAA72746.1 .
AF069429 Genomic DNA. Translation: AAD09385.1 .
AF338715 Genomic DNA. Translation: AAK53347.1 .
U76062 Genomic DNA. Translation: AAB61328.1 .
PIRi C90612.
T12411.
RefSeqi NP_115443.1. NC_002785.1.

3D structure databases

ProteinModelPortali O21399.
SMRi O21399. Positions 3-515.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 803279.

Organism-specific databases

CTDi 4512.

Phylogenomic databases

HOVERGENi HBG003841.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The mtDNA sequence of the ostrich and the divergence between paleognathous and neognathous birds."
    Harlid A., Janke A., Arnason U.
    Mol. Biol. Evol. 14:754-761(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Harlid A.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Primers for a PCR-based approach to complete mitochondrial genome sequencing."
    Sorenson M.D., Dimcheff D.E., Ast J.C., Yuri T., Mindell D.P.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Complete mitochondrial DNA genome sequences of extinct birds: ratite phylogenetics and the vicariance biogeography hypothesis."
    Haddrath O., Baker A.J.
    Proc. R. Soc. B 268:939-945(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Phylogenetic relationships of the ratite birds: resolving conflicts between molecular and morphological data sets."
    Lee K., Feinstein J., Cracraft J.
    (In) Mindell D.P. (eds.); Avian molecular evolution and systematics, pp.1-1, Academic Press, New York (1997)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-337.

Entry informationi

Entry nameiCOX1_STRCA
AccessioniPrimary (citable) accession number: O21399
Secondary accession number(s): O03549
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 15, 1998
Last modified: October 29, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3