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O21334 (NU4M_DASNO) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase chain 4

EC=1.6.5.3
Alternative name(s):
NADH dehydrogenase subunit 4
Gene names
Name:MT-ND4
Synonyms:MTND4, NADH4, ND4
Encoded onMitochondrion
OrganismDasypus novemcinctus (Nine-banded armadillo)
Taxonomic identifier9361 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaXenarthraCingulataDasypodidaeDasypus

Protein attributes

Sequence length459 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the complex I subunit 4 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 459459NADH-ubiquinone oxidoreductase chain 4
PRO_0000117927

Regions

Transmembrane23 – 4321Helical; Potential
Transmembrane60 – 8021Helical; Potential
Transmembrane92 – 11221Helical; Potential
Transmembrane113 – 13321Helical; Potential
Transmembrane145 – 16521Helical; Potential
Transmembrane196 – 21621Helical; Potential
Transmembrane224 – 24421Helical; Potential
Transmembrane257 – 27721Helical; Potential
Transmembrane284 – 30320Helical; Potential
Transmembrane308 – 33023Helical; Potential
Transmembrane351 – 37121Helical; Potential
Transmembrane392 – 41221Helical; Potential
Transmembrane436 – 45621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
O21334 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 85F61B43330438A4

FASTA45952,100
        10         20         30         40         50         60 
MLKLIMPTIM LIPLTWLSKK NMVWINSTTH SILISLISLS MLFQTTDSNM NFSLMFFADP 

        70         80         90        100        110        120 
LSTPLIILTT WLLPLMIIAS QSHLIKETTT RKKLYISMLI TLQALLIMTF SATELILFYI 

       130        140        150        160        170        180 
LFEATLIPTL ILITRWGNQT ERLNAGFYFL FYTLAGSLPL LVILLYMQNT MGSLNMLLIQ 

       190        200        210        220        230        240 
YFPQTLTHTW TAKLMWLACM MAFMVKMPLY GLHLWLPKAH VEAPIAGSMV LAAILLKLGG 

       250        260        270        280        290        300 
YGMMRITMIL EPTTTSMSYP FMMLSLWGMV MTTRICLRQT DLKSLIAYSS VSHMALVIMA 

       310        320        330        340        350        360 
ILIQTPWSYM GATALMIAHG LTSSMLFCLA NTNYERTHSR TMILARGLQT LLPLMASWWL 

       370        380        390        400        410        420 
LASLTNLALP PTINLIGELL VTMTTFKWSN LTILALGLNM LITALYSLYM LITTQRGKFT 

       430        440        450 
YHTYSIKPTF TRESTLMLMH LLPIMLLSIN PKIILGPLY 

« Hide

References

[1]"Phylogenetic analyses of mitochondrial DNA suggest a sister group relationship between Xenarthra (Edentata) and Ferungulates."
Arnason U., Gullberg A., Janke A.
Mol. Biol. Evol. 14:762-768(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y11832 Genomic DNA. Translation: CAA72520.1.
PIRT11450.
RefSeqNP_007468.1. NC_001821.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDNOT00000030820; ENSDNOP00000031346; ENSDNOG00000036640.
GeneID808133.

Organism-specific databases

CTD4538.

Phylogenomic databases

GeneTreeENSGT00730000111316.
HOVERGENHBG093667.

Family and domain databases

InterProIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSPR01437. NUOXDRDTASE4.
TIGRFAMsTIGR01972. NDH_I_M. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNU4M_DASNO
AccessionPrimary (citable) accession number: O21334
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families