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Protein

Cytochrome c oxidase subunit 2

Gene

cox2

Organism
Reclinomonas americana
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseImported
Biological processElectron transport, Respiratory chainUniRule annotationSAAS annotation, Transport
LigandCopperUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2UniRule annotationSAAS annotation
Gene namesi
Name:cox2Imported
Encoded oniMitochondrionImported
OrganismiReclinomonas americanaImported
Taxonomic identifieri48483 [NCBI]
Taxonomic lineageiEukaryotaJakobidaHistionidaeReclinomonas

Subcellular locationi

  • Mitochondrion inner membrane SAAS annotation; Multi-pass membrane protein SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Transmembranei90 – 112HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_500415769919 – 260Cytochrome c oxidase subunit 2Sequence analysisAdd BLAST242

Structurei

3D structure databases

ProteinModelPortaliO21294
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 118COX2_TMInterPro annotationAdd BLAST96
Domaini119 – 256COX2_CUAInterPro annotationAdd BLAST138

Sequence similaritiesi

Belongs to the cytochrome c oxidase subunit 2 family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

O21294-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLVALIFII ISYGMVDSLR ADYAEKWQLD FQDPATPVME GIINLHHDLW
60 70 80 90 100
FFLILIAVFV LWILLRTLWF FDRSRGTVPS KVVHGTVLEI VWTIAPSFIL
110 120 130 140 150
LAIAIPSFAL LYSMEESTDP AITLKAIGHQ WYWSYEYSDY TTDSESLAFD
160 170 180 190 200
SYMLPESELK EGQLRLLEVD NRIFLPTHTH LRVLITSSDV LHSWAVPSLG
210 220 230 240 250
VKVDACPGRL NQASIFLKRE GIFYGQCSEI CGVNHGFMPI VIEAVPLKEY
260
VSWVSSQIQI
Length:260
Mass (Da):29,680
Last modified:January 1, 1998 - v1
Checksum:i5435B7BE7109041C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007261 Genomic DNA Translation: AAD11924.1
PIRiS78191
RefSeqiNP_044809.1, NC_001823.1

Genome annotation databases

GeneIDi801121

Similar proteinsi

Entry informationi

Entry nameiO21294_RECAM
AccessioniPrimary (citable) accession number: O21294
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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