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Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

nad4

Organism
Reclinomonas americana
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

NADUniRule annotation, UbiquinoneUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4UniRule annotation (EC:1.6.5.3UniRule annotation)
Gene namesi
Name:nad4Imported
Encoded oniMitochondrionImported
OrganismiReclinomonas americanaImported
Taxonomic identifieri48483 [NCBI]
Taxonomic lineageiEukaryotaJakobidaHistionidaeReclinomonas

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 27HelicalSequence analysisAdd BLAST22
Transmembranei39 – 58HelicalSequence analysisAdd BLAST20
Transmembranei78 – 105HelicalSequence analysisAdd BLAST28
Transmembranei117 – 133HelicalSequence analysisAdd BLAST17
Transmembranei139 – 160HelicalSequence analysisAdd BLAST22
Transmembranei172 – 194HelicalSequence analysisAdd BLAST23
Transmembranei214 – 236HelicalSequence analysisAdd BLAST23
Transmembranei248 – 268HelicalSequence analysisAdd BLAST21
Transmembranei274 – 295HelicalSequence analysisAdd BLAST22
Transmembranei307 – 327HelicalSequence analysisAdd BLAST21
Transmembranei333 – 355HelicalSequence analysisAdd BLAST23
Transmembranei376 – 407HelicalSequence analysisAdd BLAST32
Transmembranei413 – 435HelicalSequence analysisAdd BLAST23
Transmembranei456 – 477HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MitochondrionUniRule annotationImported

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini137 – 423Proton_antipo_MInterPro annotationAdd BLAST287

Sequence similaritiesi

Belongs to the complex I subunit 4 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

O21286-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSILSTYL LPTIILTPIL GVFILFLIPG WKTSLIKQVS LYASLLTFIL
60 70 80 90 100
SLFLWIFFDK STSKFQFVYE VNWIETLNIH FSLGIDGISL FLVILTTFLI
110 120 130 140 150
PLCILTGWES IKHNIKEYMI CFLLLDALLI MIFCVLDLVL FYIFFESVLI
160 170 180 190 200
PMFIVIGVWG SRERKVRAAY MLFLYTFFGS LLMLIAIMVI YFDAGTTDIQ
210 220 230 240 250
VLLTTEFSQE RQKLLWLAFF ISFAIKIPMV PFHVWLPEAH VEAPTAGSVL
260 270 280 290 300
LAGVLLKLGG YGILRFSIPM FPEATVYFTP LVYTMSIIAI IYTSLTTLRQ
310 320 330 340 350
IDLKRIIAYS SVAHMNFVTI GMFSLNMQGL EGSILLMLSH GIVSSALFLC
360 370 380 390 400
IGVLYDRHKT RLLKYYSGVV QTMPIFATLF MLFTMANISL PGTSSFVGEF
410 420 430 440 450
LVLIGAFNSN TTVAFFATTG IILGAAYSLW LYNRVAFGNL KIEYIQFFYD
460 470 480 490
VTRREMLVFT PLVILVFVMG IYPEIFLDAM HVSVGNLIEH AKF
Length:493
Mass (Da):55,947
Last modified:January 1, 1998 - v1
Checksum:i72E5E0127BE7A44D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007261 Genomic DNA. Translation: AAD11916.1.
PIRiS78183.
RefSeqiNP_044801.1. NC_001823.1.

Genome annotation databases

GeneIDi801066.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007261 Genomic DNA. Translation: AAD11916.1.
PIRiS78183.
RefSeqiNP_044801.1. NC_001823.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi801066.

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiO21286_RECAM
AccessioniPrimary (citable) accession number: O21286
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: April 13, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.