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Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

nad4

Organism
Reclinomonas americana
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

NADUniRule annotation, UbiquinoneUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4UniRule annotation (EC:1.6.5.3UniRule annotation)
Gene namesi
Name:nad4Imported
Encoded oniMitochondrionImported
OrganismiReclinomonas americanaImported
Taxonomic identifieri48483 [NCBI]
Taxonomic lineageiEukaryotaJakobidaHistionidaeReclinomonas

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2722HelicalSequence analysisAdd
BLAST
Transmembranei39 – 5820HelicalSequence analysisAdd
BLAST
Transmembranei78 – 10528HelicalSequence analysisAdd
BLAST
Transmembranei117 – 13317HelicalSequence analysisAdd
BLAST
Transmembranei139 – 16022HelicalSequence analysisAdd
BLAST
Transmembranei172 – 19423HelicalSequence analysisAdd
BLAST
Transmembranei214 – 23623HelicalSequence analysisAdd
BLAST
Transmembranei248 – 26821HelicalSequence analysisAdd
BLAST
Transmembranei274 – 29522HelicalSequence analysisAdd
BLAST
Transmembranei307 – 32721HelicalSequence analysisAdd
BLAST
Transmembranei333 – 35523HelicalSequence analysisAdd
BLAST
Transmembranei376 – 40732HelicalSequence analysisAdd
BLAST
Transmembranei413 – 43523HelicalSequence analysisAdd
BLAST
Transmembranei456 – 47722HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MitochondrionUniRule annotationImported

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini137 – 423287Proton_antipo_MInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the complex I subunit 4 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

O21286-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSILSTYL LPTIILTPIL GVFILFLIPG WKTSLIKQVS LYASLLTFIL
60 70 80 90 100
SLFLWIFFDK STSKFQFVYE VNWIETLNIH FSLGIDGISL FLVILTTFLI
110 120 130 140 150
PLCILTGWES IKHNIKEYMI CFLLLDALLI MIFCVLDLVL FYIFFESVLI
160 170 180 190 200
PMFIVIGVWG SRERKVRAAY MLFLYTFFGS LLMLIAIMVI YFDAGTTDIQ
210 220 230 240 250
VLLTTEFSQE RQKLLWLAFF ISFAIKIPMV PFHVWLPEAH VEAPTAGSVL
260 270 280 290 300
LAGVLLKLGG YGILRFSIPM FPEATVYFTP LVYTMSIIAI IYTSLTTLRQ
310 320 330 340 350
IDLKRIIAYS SVAHMNFVTI GMFSLNMQGL EGSILLMLSH GIVSSALFLC
360 370 380 390 400
IGVLYDRHKT RLLKYYSGVV QTMPIFATLF MLFTMANISL PGTSSFVGEF
410 420 430 440 450
LVLIGAFNSN TTVAFFATTG IILGAAYSLW LYNRVAFGNL KIEYIQFFYD
460 470 480 490
VTRREMLVFT PLVILVFVMG IYPEIFLDAM HVSVGNLIEH AKF
Length:493
Mass (Da):55,947
Last modified:January 1, 1998 - v1
Checksum:i72E5E0127BE7A44D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007261 Genomic DNA. Translation: AAD11916.1.
PIRiS78183.
RefSeqiNP_044801.1. NC_001823.1.

Genome annotation databases

GeneIDi801066.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007261 Genomic DNA. Translation: AAD11916.1.
PIRiS78183.
RefSeqiNP_044801.1. NC_001823.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi801066.

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "An ancestral mitochondrial DNA resembling a eubacterial genome in miniature."
    Lang B.F., Burger G., O'Kelly C.J., Cedergren R., Golding G.B., Lemieux C., Sankoff D., Turmel M., Gray M.W.
    Nature 387:493-497(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC50394Imported.

Entry informationi

Entry nameiO21286_RECAM
AccessioniPrimary (citable) accession number: O21286
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: April 13, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.