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Protein

NADH-ubiquinone oxidoreductase chain 5

Gene

nad5

Organism
Reclinomonas americana
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.SAAS annotation

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotationImported
Biological processElectron transport, Respiratory chainSAAS annotation, Transport
LigandNADUniRule annotationSAAS annotation, UbiquinoneUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 5UniRule annotationSAAS annotation (EC:1.6.5.3UniRule annotation)
Gene namesi
Name:nad5Imported
Encoded oniMitochondrionImported
OrganismiReclinomonas americanaImported
Taxonomic identifieri48483 [NCBI]
Taxonomic lineageiEukaryotaJakobidaHistionidaeReclinomonas

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotationSAAS annotation; Multi-pass membrane protein UniRule annotationSAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 24HelicalSequence analysisAdd BLAST19
Transmembranei36 – 61HelicalSequence analysisAdd BLAST26
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei113 – 130HelicalSequence analysisAdd BLAST18
Transmembranei136 – 155HelicalSequence analysisAdd BLAST20
Transmembranei176 – 199HelicalSequence analysisAdd BLAST24
Transmembranei211 – 232HelicalSequence analysisAdd BLAST22
Transmembranei253 – 271HelicalSequence analysisAdd BLAST19
Transmembranei283 – 304HelicalSequence analysisAdd BLAST22
Transmembranei311 – 331HelicalSequence analysisAdd BLAST21
Transmembranei343 – 361HelicalSequence analysisAdd BLAST19
Transmembranei373 – 399HelicalSequence analysisAdd BLAST27
Transmembranei419 – 441HelicalSequence analysisAdd BLAST23
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Transmembranei519 – 539HelicalSequence analysisAdd BLAST21
Transmembranei621 – 645HelicalSequence analysisAdd BLAST25
Transmembranei651 – 667HelicalSequence analysisAdd BLAST17

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 118Proton_antipo_NInterPro annotationAdd BLAST58
Domaini131 – 420Proton_antipo_MInterPro annotationAdd BLAST290
Domaini434 – 487NADH5_CInterPro annotationAdd BLAST54
Domaini512 – 637NADH5_CInterPro annotationAdd BLAST126

Sequence similaritiesi

Belongs to the complex I subunit 5 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

InterProiView protein in InterPro
IPR010934. NADH_DH_su5_C.
IPR003945. NADHpl_OxRdtase_5.
IPR018393. NADHpl_OxRdtase_5_subgr.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
PfamiView protein in Pfam
PF06455. NADH5_C. 2 hits.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
PRINTSiPR01435. NPOXDRDTASE5.
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.

Sequencei

Sequence statusi: Complete.

O21285-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLLIVFLPL LGSITAGFFG RYLGKQGAAI ITTSCVGLSS LFSMVAFYEV
60 70 80 90 100
GLCGSPCYLR LFNWIDSEML HASWGFLFDS LTVVMLIVVT IVSSLVHLYS
110 120 130 140 150
IGYMSHDPHL PRFMSYLSLF TFFMLMLVTG DNFVQMFLGW EGVGLCSYLL
160 170 180 190 200
INFWFTRLQA NKSAIKAMIM NRIGDFGLSL GMMAIFFTFK SVDFITVFAL
210 220 230 240 250
SPYMTDFNII FFNYEVHALT LICILLFVGA VGKSSQLGLH TWLPDAMEGP
260 270 280 290 300
TPVSALIHAA TMVTAGVFLI ARCSPIFEYA PTALLVVTIV GAMTAFFAAT
310 320 330 340 350
TGLLQNDIKR VIAYSTCSQL GYMVFACGIS GYSVGMFHLM NHAFFKALLF
360 370 380 390 400
LSAGCVIHAL ADEQDMRRMG GIVKIVPFTY GMMLIGSMSL MGFPFLTGFY
410 420 430 440 450
SKDVILELAF AKYTIDGTFA HWLGTVAAFF TAFYSFRLIY LTFLGETNSP
460 470 480 490 500
RTIINHAHDA PFIMAFPLMI LAVGSIFVGF VMKDMMIGLG TDFWGNSLFT
510 520 530 540 550
HPKNLTLIES EFIPTPIKLL PVVLSITGAT LAIILNNYCA RFLVDLKISS
560 570 580 590 600
LGRELYSFLN KRWYFDIVYN EYVGRTMLWF GYNISFKTID KGLIEILGPY
610 620 630 640 650
GLERLVKRLT LRVSQLQTGY IYHYAFIMLF GITLIITIVG LWDYISEWTD
660 670
YRLYFIYLIT VLFYGYSETK
Length:670
Mass (Da):75,329
Last modified:January 1, 1998 - v1
Checksum:i2803656760951800
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007261 Genomic DNA. Translation: AAD11915.1.
PIRiS78182.
RefSeqiNP_044800.1. NC_001823.1.

Genome annotation databases

GeneIDi801079.

Similar proteinsi

Entry informationi

Entry nameiO21285_RECAM
AccessioniPrimary (citable) accession number: O21285
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: June 7, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)