Reviewed, UniProtKB/Swiss-Prot O21280 (CCMA_RECAM)

Names and origin

Protein names

Recommended name:
    Cytochrome c biogenesis ATP-binding export protein ccmA
    EC=3.6.3.41
Alternative name(s):
    Heme exporter protein A

Gene names

Name:

CCMA

Encoded on

Mitochondrion

Organism

Reclinomonas americana

Taxonomic identifier

48483 [NCBI]

Taxonomic lineage

Eukaryota › Jakobida › Histionidae › Reclinomonas

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Part of the ABC transporter complex ccmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system By similarity.
Catalytic activity	ATP + H2O + heme(In) = ADP + phosphate + heme(Out).
Subunit structure	The complex is composed of two ATP-binding proteins (ccmA) and two transmembrane proteins (ccmB) Probable.
Subcellular location	Mitochondrion membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. [View classification] Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Cytochrome c-type biogenesis Transport
Cellular component	Membrane Mitochondrion
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	cytochrome complex assembly Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from electronic annotation. Source: UniProtKB-KW outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW heme-transporting ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 222	222	Cytochrome c biogenesis ATP-binding export protein ccmA		PRO_0000092229
Regions
	Domain	9 – 222	214	ABC transporter
	Nucleotide binding	41 – 48	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	O21280-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: A343CBFB8393A5A9	FASTA	222	25,502
	10 20 30 40 50 60 MNLTKIQNLT IHNITGIRSN KIIFQNINFS LEKGSLFIIQ GSNGSGKTTL LKIISGLLPK 70 80 90 100 110 120 SQGDIIINNN FISENYLKDS LFYMDSTPSF KEDITLLDYL IYWNTLYNGL QNISYEYIRT 130 140 150 160 170 180 SLFQLGLSHL QNKKISTLSL GQKKRLLISK LLLTNKQLWI LDEPLIGLDK YWIKIFSTIL 190 200 210 220 LKHCKRGGII IMSTHTDLNI KKNTFLILNT TNKFIQTLNN LI

References

[1]

"An ancestral mitochondrial DNA resembling a eubacterial genome in miniature." Lang B.F., Burger G., O'Kelly C.J., Cedergren R., Golding G.B., Lemieux C., Sankoff D., Turmel M., Gray M.W. Nature 387:493-497(1997) [PubMed: 9168110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 50394.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF007261 Genomic DNA. Translation: AAD11907.1.
PIR	S78174.
RefSeq	NP_044792.1.
3D structure databases
SMR	O21280. Positions 20-200.
ModBase	Search...
Genome annotation databases
GeneID	801082.
Enzyme and pathway databases
BRENDA	3.6.3.41. 307247.
Family and domain databases
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR005895. ABC_transptr_haem_export_CcmA. IPR003593. ATPase_AAA+_core. [Graphical view]
PANTHER	PTHR19222:SF5. CcmA. 1 hit.
Pfam	PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01189. ccmA. 1 hit.
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. PS51243. CCMA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCMA_RECAM

Accession

Primary (citable) accession number: O21280

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	January 1, 1998
Last modified:	February 9, 2010
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)