ID   NDUS2_RECAM             Reviewed;         396 AA.
AC   O21270;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-JUN-2009, entry version 56.
DE   RecName: Full=NADH-ubiquinone oxidoreductase 49 kDa subunit;
DE            EC=1.6.5.3;
DE            EC=1.6.99.3;
DE   AltName: Full=NADH dehydrogenase subunit 7;
GN   Name=NAD7;
OS   Reclinomonas americana.
OG   Mitochondrion.
OC   Eukaryota; Jakobida; Histionidae; Reclinomonas.
OX   NCBI_TaxID=48483;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 50394;
RX   MEDLINE=97311393; PubMed=9168110; DOI=10.1038/387493a0;
RA   Lang B.F., Burger G., O'Kelly C.J., Cedergren R., Golding G.B.,
RA   Lemieux C., Sankoff D., Turmel M., Gray M.W.;
RT   "An ancestral mitochondrial DNA resembling a eubacterial genome in
RT   miniature.";
RL   Nature 387:493-497(1997).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I) that is believed to belong to
CC       the minimal assembly required for catalysis. Complex I functions
CC       in the transfer of electrons from NADH to the respiratory chain.
CC       The immediate electron acceptor for the enzyme is believed to be
CC       ubiquinone (By similarity). Component of the iron-sulfur (IP)
CC       fragment of the enzyme. Component of the iron-sulfur (IP) fragment
CC       of the enzyme.
CC   -!- CATALYTIC ACTIVITY: NADH + ubiquinone = NAD(+) + ubiquinol.
CC   -!- CATALYTIC ACTIVITY: NADH + acceptor = NAD(+) + reduced acceptor.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion.
CC   -!- SIMILARITY: Belongs to the complex I 49 kDa subunit family.
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DR   EMBL; AF007261; AAD11897.1; -; Genomic_DNA.
DR   PIR; S78164; S78164.
DR   RefSeq; NP_044782.1; -.
DR   GeneID; 801113; -.
DR   BRENDA; 1.6.5.3; 307247.
DR   BRENDA; 1.6.99.3; 307247.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0051287; F:NAD or NADH binding; IEA:InterPro.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:EC.
DR   GO; GO:0048038; F:quinone binding; IEA:InterPro.
DR   GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   InterPro; IPR010219; NADH_DH_1_dsu.
DR   InterPro; IPR001135; NADH_Q_OxRdtase_suD.
DR   InterPro; IPR014029; NADH_UbQ_OxRdtase_su-49kDa_CS.
DR   Pfam; PF00346; Complex1_49kDa; 1.
DR   TIGRFAMs; TIGR01962; NuoD; 1.
DR   PROSITE; PS00535; COMPLEX1_49K; 1.
PE   3: Inferred from homology;
KW   Electron transport; Mitochondrion; NAD; Oxidoreductase;
KW   Respiratory chain; Transport; Ubiquinone.
FT   CHAIN         1    396       NADH-ubiquinone oxidoreductase 49 kDa
FT                                subunit.
FT                                /FTId=PRO_0000118593.
SQ   SEQUENCE   396 AA;  44993 MW;  252B68E29305F096 CRC64;
     MQQKALTKKL KNFTMNFGPQ HPAAHGVLRL VLELNGEVVN RADPHIGLLH RGTEKLIEYK
     NYLQALPYFD RLDYVSMMAQ EHAYSLAVEK LLGCEVPKRA QYIRVLFCEI TRILNHLMAV
     TTHALDVGAM TPFLWGFEER EKLMEFYERV SGARMHAAYI RPGGVSQDMP MGLSEDIYKF
     AKQFGSRIDE IEDVLSSNRI WKQRLVDIGT VSAEEALDWG FSGVMLRGSG IAWDLRKTQP
     YDVYDELEFD IPVGTKGDCY DRYLIRVEEM RQSLKLIMQC LNKMPTGVIK VDDKKISPPS
     RVDMKDSMEA LIHHFKLYTE GYSVPIGETY TAVEAPKGEF GVYLVSDGSS KPYRCKIKAP
     GFSHLQGLNF MSKGHMIADV VTIIGTQDIV FGEVDR
//