O21270 (NDUS2_RECAM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NADH-ubiquinone oxidoreductase 49 kDa subunit
EC=1.6.5.3
EC=1.6.99.3

Alternative name(s):
NADH dehydrogenase subunit 7

Gene names

Name:

NAD7

Encoded on

Mitochondrion

Organism

Reclinomonas americana

Taxonomic identifier

48483 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Jakobida › Histionidae › Reclinomonas

Protein attributes

Sequence length	396 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme.
Catalytic activity	NADH + ubiquinone = NAD+ + ubiquinol. NADH + acceptor = NAD+ + reduced acceptor.
Subcellular location	Mitochondrion.
Sequence similarities	Belongs to the complex I 49 kDa subunit family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Mitochondrion
Ligand	NAD Ubiquinone
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	NAD binding Inferred from electronic annotation. Source: InterPro NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: EC quinone binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 396	396	NADH-ubiquinone oxidoreductase 49 kDa subunit		PRO_0000118593

Sequences

	Sequence		Length	Mass (Da)
	O21270 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 252B68E29305F096	FASTA	396	44,993
	10 20 30 40 50 60 MQQKALTKKL KNFTMNFGPQ HPAAHGVLRL VLELNGEVVN RADPHIGLLH RGTEKLIEYK 70 80 90 100 110 120 NYLQALPYFD RLDYVSMMAQ EHAYSLAVEK LLGCEVPKRA QYIRVLFCEI TRILNHLMAV 130 140 150 160 170 180 TTHALDVGAM TPFLWGFEER EKLMEFYERV SGARMHAAYI RPGGVSQDMP MGLSEDIYKF 190 200 210 220 230 240 AKQFGSRIDE IEDVLSSNRI WKQRLVDIGT VSAEEALDWG FSGVMLRGSG IAWDLRKTQP 250 260 270 280 290 300 YDVYDELEFD IPVGTKGDCY DRYLIRVEEM RQSLKLIMQC LNKMPTGVIK VDDKKISPPS 310 320 330 340 350 360 RVDMKDSMEA LIHHFKLYTE GYSVPIGETY TAVEAPKGEF GVYLVSDGSS KPYRCKIKAP 370 380 390 GFSHLQGLNF MSKGHMIADV VTIIGTQDIV FGEVDR

References

[1]

"An ancestral mitochondrial DNA resembling a eubacterial genome in miniature." Lang B.F., Burger G., O'Kelly C.J., Cedergren R., Golding G.B., Lemieux C., Sankoff D., Turmel M., Gray M.W. Nature 387:493-497(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 50394.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF007261 Genomic DNA. Translation: AAD11897.1.
PIR	S78164.
RefSeq	NP_044782.1. NC_001823.1.
3D structure databases
ProteinModelPortal	O21270.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	801113.
Family and domain databases
InterPro	IPR001135. NADH_Q_OxRdtase_suD. IPR014029. NADH_UbQ_OxRdtase_49kDa_CS. IPR022885. NDH1_su_D/H. [Graphical view]
Pfam	PF00346. Complex1_49kDa. 1 hit. [Graphical view]
TIGRFAMs	TIGR01962. NuoD. 1 hit.
PROSITE	PS00535. COMPLEX1_49K. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NDUS2_RECAM

Accession

Primary (citable) accession number: O21270

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1998
Last modified:	April 3, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)