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O21270 (NDUS2_RECAM) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase 49 kDa subunit

EC=1.6.5.3
EC=1.6.99.3
Alternative name(s):
NADH dehydrogenase subunit 7
Gene names
Name:NAD7
Encoded onMitochondrion
OrganismReclinomonas americana
Taxonomic identifier48483 [NCBI]
Taxonomic lineageEukaryotaJakobidaHistionidaeReclinomonas

Protein attributes

Sequence length396 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme. HAMAP-Rule MF_01358

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out). HAMAP-Rule MF_01358

NADH + acceptor = NAD+ + reduced acceptor. HAMAP-Rule MF_01358

Subcellular location

Mitochondrion HAMAP-Rule MF_01358.

Sequence similarities

Belongs to the complex I 49 kDa subunit family.

Ontologies

Keywords
   Biological processElectron transport
Respiratory chain
Transport
   Cellular componentMitochondrion
   LigandNAD
Ubiquinone
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

respiratory chain

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

NADH dehydrogenase (ubiquinone) activity

Inferred from electronic annotation. Source: UniProtKB-EC

quinone binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 396396NADH-ubiquinone oxidoreductase 49 kDa subunit HAMAP-Rule MF_01358
PRO_0000118593

Sequences

Sequence LengthMass (Da)Tools
O21270 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 252B68E29305F096

FASTA39644,993
        10         20         30         40         50         60 
MQQKALTKKL KNFTMNFGPQ HPAAHGVLRL VLELNGEVVN RADPHIGLLH RGTEKLIEYK 

        70         80         90        100        110        120 
NYLQALPYFD RLDYVSMMAQ EHAYSLAVEK LLGCEVPKRA QYIRVLFCEI TRILNHLMAV 

       130        140        150        160        170        180 
TTHALDVGAM TPFLWGFEER EKLMEFYERV SGARMHAAYI RPGGVSQDMP MGLSEDIYKF 

       190        200        210        220        230        240 
AKQFGSRIDE IEDVLSSNRI WKQRLVDIGT VSAEEALDWG FSGVMLRGSG IAWDLRKTQP 

       250        260        270        280        290        300 
YDVYDELEFD IPVGTKGDCY DRYLIRVEEM RQSLKLIMQC LNKMPTGVIK VDDKKISPPS 

       310        320        330        340        350        360 
RVDMKDSMEA LIHHFKLYTE GYSVPIGETY TAVEAPKGEF GVYLVSDGSS KPYRCKIKAP 

       370        380        390 
GFSHLQGLNF MSKGHMIADV VTIIGTQDIV FGEVDR 

« Hide

References

[1]"An ancestral mitochondrial DNA resembling a eubacterial genome in miniature."
Lang B.F., Burger G., O'Kelly C.J., Cedergren R., Golding G.B., Lemieux C., Sankoff D., Turmel M., Gray M.W.
Nature 387:493-497(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 50394.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF007261 Genomic DNA. Translation: AAD11897.1.
PIRS78164.
RefSeqNP_044782.1. NC_001823.1.

3D structure databases

ProteinModelPortalO21270.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID801113.

Family and domain databases

HAMAPMF_01358. NDH1_NuoD.
InterProIPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
[Graphical view]
PfamPF00346. Complex1_49kDa. 1 hit.
[Graphical view]
TIGRFAMsTIGR01962. NuoD. 1 hit.
PROSITEPS00535. COMPLEX1_49K. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNDUS2_RECAM
AccessionPrimary (citable) accession number: O21270
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: February 19, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families