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Protein

NADH-ubiquinone oxidoreductase 49 kDa subunit

Gene

NAD7

Organism
Reclinomonas americana
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme.By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase 49 kDa subunit (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
NADH dehydrogenase subunit 7
Gene namesi
Name:NAD7
Encoded oniMitochondrion
OrganismiReclinomonas americana
Taxonomic identifieri48483 [NCBI]
Taxonomic lineageiEukaryotaJakobidaHistionidaeReclinomonas

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001185931 – 396NADH-ubiquinone oxidoreductase 49 kDa subunitAdd BLAST396

Structurei

3D structure databases

ProteinModelPortaliO21270
SMRiO21270
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 49 kDa subunit family.Curated

Family and domain databases

Gene3Di1.10.645.20, 1 hit
HAMAPiMF_01358 NDH1_NuoD, 1 hit
InterProiView protein in InterPro
IPR001135 NADH_Q_OxRdtase_suD
IPR038290 NADH_Q_OxRdtase_suD_sf
IPR014029 NADH_UbQ_OxRdtase_49kDa_CS
IPR022885 NDH1_su_D/H
IPR029014 NiFe-Hase_large
PfamiView protein in Pfam
PF00346 Complex1_49kDa, 1 hit
SUPFAMiSSF56762 SSF56762, 1 hit
TIGRFAMsiTIGR01962 NuoD, 1 hit
PROSITEiView protein in PROSITE
PS00535 COMPLEX1_49K, 1 hit

Sequencei

Sequence statusi: Complete.

O21270-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQKALTKKL KNFTMNFGPQ HPAAHGVLRL VLELNGEVVN RADPHIGLLH
60 70 80 90 100
RGTEKLIEYK NYLQALPYFD RLDYVSMMAQ EHAYSLAVEK LLGCEVPKRA
110 120 130 140 150
QYIRVLFCEI TRILNHLMAV TTHALDVGAM TPFLWGFEER EKLMEFYERV
160 170 180 190 200
SGARMHAAYI RPGGVSQDMP MGLSEDIYKF AKQFGSRIDE IEDVLSSNRI
210 220 230 240 250
WKQRLVDIGT VSAEEALDWG FSGVMLRGSG IAWDLRKTQP YDVYDELEFD
260 270 280 290 300
IPVGTKGDCY DRYLIRVEEM RQSLKLIMQC LNKMPTGVIK VDDKKISPPS
310 320 330 340 350
RVDMKDSMEA LIHHFKLYTE GYSVPIGETY TAVEAPKGEF GVYLVSDGSS
360 370 380 390
KPYRCKIKAP GFSHLQGLNF MSKGHMIADV VTIIGTQDIV FGEVDR
Length:396
Mass (Da):44,993
Last modified:January 1, 1998 - v1
Checksum:i252B68E29305F096
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007261 Genomic DNA Translation: AAD11897.1
PIRiS78164
RefSeqiNP_044782.1, NC_001823.1

Genome annotation databases

GeneIDi801113

Similar proteinsi

Entry informationi

Entry nameiNDUS2_RECAM
AccessioniPrimary (citable) accession number: O21270
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health