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O21049

- COX3_DICDI

UniProt

O21049 - COX3_DICDI

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Protein
Cytochrome c oxidase subunit 3
Gene
cox3, DDB_G0294092
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex By similarity.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:cox3
ORF Names:DDB_G0294092
Encoded oniMitochondrion
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Mitochondrion

Organism-specific databases

dictyBaseiDDB_G0294092. cox3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei70 – 9021Helical; Reviewed prediction
Add
BLAST
Transmembranei96 – 11621Helical; Reviewed prediction
Add
BLAST
Transmembranei132 – 15221Helical; Reviewed prediction
Add
BLAST
Transmembranei176 – 19621Helical; Reviewed prediction
Add
BLAST
Transmembranei325 – 34521Helical; Reviewed prediction
Add
BLAST
Transmembranei360 – 38021Helical; Reviewed prediction
Add
BLAST
Transmembranei412 – 43221Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Cytochrome c oxidase subunit 3
PRO_0000312370Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DidioMp04.

Structurei

3D structure databases

ProteinModelPortaliO21049.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1845.
KOiK02262.
PhylomeDBiO21049.

Family and domain databases

Gene3Di1.20.120.80. 2 hits.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 2 hits.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 2 hits.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O21049-1 [UniParc]FASTAAdd to Basket

« Hide

MKGFFENLFR QNVRSVINTG KKVGARAAAR EIINQEWGYP LANHEVLFLT    50
NVYQPKHMKR HPFHIVRGTV APLAVTLPLG FFVLNYFGVI SSKLGLLIAL 100
SSFIGGLVIW TISIIFDSLY DQQHTYEVKR GLVMGMMMFI ISEVMFFFSF 150
FWSYFYISLS PNIAIGCVWP PYGLTVYSYM GLPLLNTVLL LLSGAILTDG 200
YTILTEQKAV HEKNEKVLAV EEAFKNLMNL YKTKNSINTL TFVDERRDKF 250
FGKESRQEDK IAEQKLIAIS AGVKELRDLD WDLYFFENPE NIEPNYKEPT 300
NLSVIEYALI TIYLKKRNKV IKTRLYFTLL CAVVFLACQG YEYFFAPFSM 350
NDGIYGSLFF LLTGFHGFHV LVGSILIGII TIRFIVGNFN LLNVGTNFQI 400
YKNKSTGFAC TLFYWHFVDI VWIFLYIVIY WWGSR 435
Length:435
Mass (Da):50,234
Last modified:January 1, 1998 - v1
Checksum:i5AC920869B67F434
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16579 Genomic DNA. Translation: BAA21120.1.
AB000109 Genomic DNA. Translation: BAA78053.1.
PIRiT43749.
RefSeqiNP_050071.1. NC_000895.1.

Genome annotation databases

GeneIDi2193893.
KEGGiddi:DidioMp04.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16579 Genomic DNA. Translation: BAA21120.1 .
AB000109 Genomic DNA. Translation: BAA78053.1 .
PIRi T43749.
RefSeqi NP_050071.1. NC_000895.1.

3D structure databases

ProteinModelPortali O21049.
ModBasei Search...

Protein-protein interaction databases

STRINGi 44689.DidioMp04.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2193893.
KEGGi ddi:DidioMp04.

Organism-specific databases

dictyBasei DDB_G0294092. cox3.

Phylogenomic databases

eggNOGi COG1845.
KOi K02262.
PhylomeDBi O21049.

Miscellaneous databases

PROi O21049.

Family and domain databases

Gene3Di 1.20.120.80. 2 hits.
InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view ]
PANTHERi PTHR11403. PTHR11403. 1 hit.
Pfami PF00510. COX3. 2 hits.
[Graphical view ]
SUPFAMi SSF81452. SSF81452. 2 hits.
PROSITEi PS50253. COX3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Group-I introns in the cytochrome c oxidase genes of Dictyostelium discoideum: two related ORFs in one loop of a group-I intron, a cox1/2 hybrid gene and an unusually large cox3 gene."
    Ogawa S., Matsuo K., Angata K., Yanagisawa K., Tanaka Y.
    Curr. Genet. 31:80-88(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: AX3.
  2. "The mitochondrial DNA of Dictyostelium discoideum: complete sequence, gene content and genome organization."
    Ogawa S., Yoshino R., Angata K., Iwamoto M., Pi M., Kuroe K., Matsuo K., Morio T., Urushihara H., Yanagisawa K., Tanaka Y.
    Mol. Gen. Genet. 263:514-519(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX3.

Entry informationi

Entry nameiCOX3_DICDI
AccessioniPrimary (citable) accession number: O21049
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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