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Protein

Cytochrome c oxidase subunit 3

Gene

cox3

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:cox3
ORF Names:DDB_G0294092
Encoded oniMitochondrion
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195 Componenti: Mitochondrion

Organism-specific databases

dictyBaseiDDB_G0294092. cox3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei70 – 9021HelicalSequence AnalysisAdd
BLAST
Transmembranei96 – 11621HelicalSequence AnalysisAdd
BLAST
Transmembranei132 – 15221HelicalSequence AnalysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence AnalysisAdd
BLAST
Transmembranei325 – 34521HelicalSequence AnalysisAdd
BLAST
Transmembranei360 – 38021HelicalSequence AnalysisAdd
BLAST
Transmembranei412 – 43221HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Cytochrome c oxidase subunit 3PRO_0000312370Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO21049.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1845.
InParanoidiO21049.
KOiK02262.
PhylomeDBiO21049.

Family and domain databases

Gene3Di1.20.120.80. 2 hits.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 2 hits.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 2 hits.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O21049-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGFFENLFR QNVRSVINTG KKVGARAAAR EIINQEWGYP LANHEVLFLT
60 70 80 90 100
NVYQPKHMKR HPFHIVRGTV APLAVTLPLG FFVLNYFGVI SSKLGLLIAL
110 120 130 140 150
SSFIGGLVIW TISIIFDSLY DQQHTYEVKR GLVMGMMMFI ISEVMFFFSF
160 170 180 190 200
FWSYFYISLS PNIAIGCVWP PYGLTVYSYM GLPLLNTVLL LLSGAILTDG
210 220 230 240 250
YTILTEQKAV HEKNEKVLAV EEAFKNLMNL YKTKNSINTL TFVDERRDKF
260 270 280 290 300
FGKESRQEDK IAEQKLIAIS AGVKELRDLD WDLYFFENPE NIEPNYKEPT
310 320 330 340 350
NLSVIEYALI TIYLKKRNKV IKTRLYFTLL CAVVFLACQG YEYFFAPFSM
360 370 380 390 400
NDGIYGSLFF LLTGFHGFHV LVGSILIGII TIRFIVGNFN LLNVGTNFQI
410 420 430
YKNKSTGFAC TLFYWHFVDI VWIFLYIVIY WWGSR
Length:435
Mass (Da):50,234
Last modified:January 1, 1998 - v1
Checksum:i5AC920869B67F434
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16579 Genomic DNA. Translation: BAA21120.1.
AB000109 Genomic DNA. Translation: BAA78053.1.
PIRiT43749.
RefSeqiNP_050071.1. NC_000895.1.

Genome annotation databases

GeneIDi2193893.
KEGGiddi:DidioMp04.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16579 Genomic DNA. Translation: BAA21120.1.
AB000109 Genomic DNA. Translation: BAA78053.1.
PIRiT43749.
RefSeqiNP_050071.1. NC_000895.1.

3D structure databases

ProteinModelPortaliO21049.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2193893.
KEGGiddi:DidioMp04.

Organism-specific databases

dictyBaseiDDB_G0294092. cox3.

Phylogenomic databases

eggNOGiCOG1845.
InParanoidiO21049.
KOiK02262.
PhylomeDBiO21049.

Miscellaneous databases

PROiO21049.

Family and domain databases

Gene3Di1.20.120.80. 2 hits.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 2 hits.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 2 hits.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Group-I introns in the cytochrome c oxidase genes of Dictyostelium discoideum: two related ORFs in one loop of a group-I intron, a cox1/2 hybrid gene and an unusually large cox3 gene."
    Ogawa S., Matsuo K., Angata K., Yanagisawa K., Tanaka Y.
    Curr. Genet. 31:80-88(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: AX3.
  2. "The mitochondrial DNA of Dictyostelium discoideum: complete sequence, gene content and genome organization."
    Ogawa S., Yoshino R., Angata K., Iwamoto M., Pi M., Kuroe K., Matsuo K., Morio T., Urushihara H., Yanagisawa K., Tanaka Y.
    Mol. Gen. Genet. 263:514-519(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX3.

Entry informationi

Entry nameiCOX3_DICDI
AccessioniPrimary (citable) accession number: O21049
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: January 1, 1998
Last modified: June 24, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.