O21049 (COX3_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 3
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide III

Gene names

Name:	cox3
ORF Names:	DDB_G0294092

Encoded on

Mitochondrion

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	435 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Subunits I, II and III form the functional core of the enzyme complex By similarity.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aerobic electron transport chain Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 435	435	Cytochrome c oxidase subunit 3		PRO_0000312370
Regions
	Transmembrane	70 – 90	21	Helical; Potential
	Transmembrane	96 – 116	21	Helical; Potential
	Transmembrane	132 – 152	21	Helical; Potential
	Transmembrane	176 – 196	21	Helical; Potential
	Transmembrane	325 – 345	21	Helical; Potential
	Transmembrane	360 – 380	21	Helical; Potential
	Transmembrane	412 – 432	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	O21049 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 5AC920869B67F434	FASTA	435	50,234
	10 20 30 40 50 60 MKGFFENLFR QNVRSVINTG KKVGARAAAR EIINQEWGYP LANHEVLFLT NVYQPKHMKR 70 80 90 100 110 120 HPFHIVRGTV APLAVTLPLG FFVLNYFGVI SSKLGLLIAL SSFIGGLVIW TISIIFDSLY 130 140 150 160 170 180 DQQHTYEVKR GLVMGMMMFI ISEVMFFFSF FWSYFYISLS PNIAIGCVWP PYGLTVYSYM 190 200 210 220 230 240 GLPLLNTVLL LLSGAILTDG YTILTEQKAV HEKNEKVLAV EEAFKNLMNL YKTKNSINTL 250 260 270 280 290 300 TFVDERRDKF FGKESRQEDK IAEQKLIAIS AGVKELRDLD WDLYFFENPE NIEPNYKEPT 310 320 330 340 350 360 NLSVIEYALI TIYLKKRNKV IKTRLYFTLL CAVVFLACQG YEYFFAPFSM NDGIYGSLFF 370 380 390 400 410 420 LLTGFHGFHV LVGSILIGII TIRFIVGNFN LLNVGTNFQI YKNKSTGFAC TLFYWHFVDI 430 VWIFLYIVIY WWGSR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Group-I introns in the cytochrome c oxidase genes of Dictyostelium discoideum: two related ORFs in one loop of a group-I intron, a cox1/2 hybrid gene and an unusually large cox3 gene." Ogawa S., Matsuo K., Angata K., Yanagisawa K., Tanaka Y. Curr. Genet. 31:80-88(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: AX3.
[2]	"The mitochondrial DNA of Dictyostelium discoideum: complete sequence, gene content and genome organization." Ogawa S., Yoshino R., Angata K., Iwamoto M., Pi M., Kuroe K., Matsuo K., Morio T., Urushihara H., Yanagisawa K., Tanaka Y. Mol. Gen. Genet. 263:514-519(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX3.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D16579 Genomic DNA. Translation: BAA21120.1. AB000109 Genomic DNA. Translation: BAA78053.1.
PIR	T43749.
RefSeq	NP_050071.1. NC_000895.1.
3D structure databases
ProteinModelPortal	O21049.
ModBase	Search...
Protein-protein interaction databases
STRING	44689.DidioMp04.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2193893.
KEGG	ddi:DidioMp04.
Organism-specific databases
dictyBase	DDB_G0294092. cox3.
Phylogenomic databases
eggNOG	COG1845.
KO	K02262.
Family and domain databases
Gene3D	1.20.120.80. 2 hits.
InterPro	IPR024791. Cyt_c/ubiquinol_Oxase_su3. IPR000298. Cyt_c_oxidase_su3. IPR013833. Cyt_c_oxidase_su3_a-hlx. [Graphical view]
PANTHER	PTHR11403. PTHR11403. 1 hit.
Pfam	PF00510. COX3. 2 hits. [Graphical view]
SUPFAM	SSF81452. CytC_oxdse_III. 2 hits.
PROSITE	PS50253. COX3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX3_DICDI

Accession

Primary (citable) accession number: O21049

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)