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O21049

- COX3_DICDI

UniProt

O21049 - COX3_DICDI

Protein

Cytochrome c oxidase subunit 3

Gene

cox3

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Subunits I, II and III form the functional core of the enzyme complex.By similarity

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. aerobic electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide III
    Gene namesi
    Name:cox3
    ORF Names:DDB_G0294092
    Encoded oniMitochondrion
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Mitochondrion

    Organism-specific databases

    dictyBaseiDDB_G0294092. cox3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 435435Cytochrome c oxidase subunit 3PRO_0000312370Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DidioMp04.

    Structurei

    3D structure databases

    ProteinModelPortaliO21049.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei70 – 9021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei96 – 11621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei132 – 15221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei176 – 19621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei325 – 34521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei360 – 38021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei412 – 43221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1845.
    KOiK02262.
    PhylomeDBiO21049.

    Family and domain databases

    Gene3Di1.20.120.80. 2 hits.
    InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view]
    PANTHERiPTHR11403. PTHR11403. 1 hit.
    PfamiPF00510. COX3. 2 hits.
    [Graphical view]
    SUPFAMiSSF81452. SSF81452. 2 hits.
    PROSITEiPS50253. COX3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O21049-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKGFFENLFR QNVRSVINTG KKVGARAAAR EIINQEWGYP LANHEVLFLT    50
    NVYQPKHMKR HPFHIVRGTV APLAVTLPLG FFVLNYFGVI SSKLGLLIAL 100
    SSFIGGLVIW TISIIFDSLY DQQHTYEVKR GLVMGMMMFI ISEVMFFFSF 150
    FWSYFYISLS PNIAIGCVWP PYGLTVYSYM GLPLLNTVLL LLSGAILTDG 200
    YTILTEQKAV HEKNEKVLAV EEAFKNLMNL YKTKNSINTL TFVDERRDKF 250
    FGKESRQEDK IAEQKLIAIS AGVKELRDLD WDLYFFENPE NIEPNYKEPT 300
    NLSVIEYALI TIYLKKRNKV IKTRLYFTLL CAVVFLACQG YEYFFAPFSM 350
    NDGIYGSLFF LLTGFHGFHV LVGSILIGII TIRFIVGNFN LLNVGTNFQI 400
    YKNKSTGFAC TLFYWHFVDI VWIFLYIVIY WWGSR 435
    Length:435
    Mass (Da):50,234
    Last modified:January 1, 1998 - v1
    Checksum:i5AC920869B67F434
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16579 Genomic DNA. Translation: BAA21120.1.
    AB000109 Genomic DNA. Translation: BAA78053.1.
    PIRiT43749.
    RefSeqiNP_050071.1. NC_000895.1.

    Genome annotation databases

    GeneIDi2193893.
    KEGGiddi:DidioMp04.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16579 Genomic DNA. Translation: BAA21120.1 .
    AB000109 Genomic DNA. Translation: BAA78053.1 .
    PIRi T43749.
    RefSeqi NP_050071.1. NC_000895.1.

    3D structure databases

    ProteinModelPortali O21049.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DidioMp04.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2193893.
    KEGGi ddi:DidioMp04.

    Organism-specific databases

    dictyBasei DDB_G0294092. cox3.

    Phylogenomic databases

    eggNOGi COG1845.
    KOi K02262.
    PhylomeDBi O21049.

    Miscellaneous databases

    PROi O21049.

    Family and domain databases

    Gene3Di 1.20.120.80. 2 hits.
    InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view ]
    PANTHERi PTHR11403. PTHR11403. 1 hit.
    Pfami PF00510. COX3. 2 hits.
    [Graphical view ]
    SUPFAMi SSF81452. SSF81452. 2 hits.
    PROSITEi PS50253. COX3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Group-I introns in the cytochrome c oxidase genes of Dictyostelium discoideum: two related ORFs in one loop of a group-I intron, a cox1/2 hybrid gene and an unusually large cox3 gene."
      Ogawa S., Matsuo K., Angata K., Yanagisawa K., Tanaka Y.
      Curr. Genet. 31:80-88(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: AX3.
    2. "The mitochondrial DNA of Dictyostelium discoideum: complete sequence, gene content and genome organization."
      Ogawa S., Yoshino R., Angata K., Iwamoto M., Pi M., Kuroe K., Matsuo K., Morio T., Urushihara H., Yanagisawa K., Tanaka Y.
      Mol. Gen. Genet. 263:514-519(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX3.

    Entry informationi

    Entry nameiCOX3_DICDI
    AccessioniPrimary (citable) accession number: O21049
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3