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O21049 (COX3_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene names
Name:cox3
ORF Names:DDB_G0294092
Encoded onMitochondrion
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length435 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex By similarity.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 435435Cytochrome c oxidase subunit 3
PRO_0000312370

Regions

Transmembrane70 – 9021Helical; Potential
Transmembrane96 – 11621Helical; Potential
Transmembrane132 – 15221Helical; Potential
Transmembrane176 – 19621Helical; Potential
Transmembrane325 – 34521Helical; Potential
Transmembrane360 – 38021Helical; Potential
Transmembrane412 – 43221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
O21049 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 5AC920869B67F434

FASTA43550,234
        10         20         30         40         50         60 
MKGFFENLFR QNVRSVINTG KKVGARAAAR EIINQEWGYP LANHEVLFLT NVYQPKHMKR 

        70         80         90        100        110        120 
HPFHIVRGTV APLAVTLPLG FFVLNYFGVI SSKLGLLIAL SSFIGGLVIW TISIIFDSLY 

       130        140        150        160        170        180 
DQQHTYEVKR GLVMGMMMFI ISEVMFFFSF FWSYFYISLS PNIAIGCVWP PYGLTVYSYM 

       190        200        210        220        230        240 
GLPLLNTVLL LLSGAILTDG YTILTEQKAV HEKNEKVLAV EEAFKNLMNL YKTKNSINTL 

       250        260        270        280        290        300 
TFVDERRDKF FGKESRQEDK IAEQKLIAIS AGVKELRDLD WDLYFFENPE NIEPNYKEPT 

       310        320        330        340        350        360 
NLSVIEYALI TIYLKKRNKV IKTRLYFTLL CAVVFLACQG YEYFFAPFSM NDGIYGSLFF 

       370        380        390        400        410        420 
LLTGFHGFHV LVGSILIGII TIRFIVGNFN LLNVGTNFQI YKNKSTGFAC TLFYWHFVDI 

       430 
VWIFLYIVIY WWGSR 

« Hide

References

« Hide 'large scale' references
[1]"Group-I introns in the cytochrome c oxidase genes of Dictyostelium discoideum: two related ORFs in one loop of a group-I intron, a cox1/2 hybrid gene and an unusually large cox3 gene."
Ogawa S., Matsuo K., Angata K., Yanagisawa K., Tanaka Y.
Curr. Genet. 31:80-88(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: AX3.
[2]"The mitochondrial DNA of Dictyostelium discoideum: complete sequence, gene content and genome organization."
Ogawa S., Yoshino R., Angata K., Iwamoto M., Pi M., Kuroe K., Matsuo K., Morio T., Urushihara H., Yanagisawa K., Tanaka Y.
Mol. Gen. Genet. 263:514-519(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX3.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D16579 Genomic DNA. Translation: BAA21120.1.
AB000109 Genomic DNA. Translation: BAA78053.1.
PIRT43749.
RefSeqNP_050071.1. NC_000895.1.

3D structure databases

ProteinModelPortalO21049.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DidioMp04.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2193893.
KEGGddi:DidioMp04.

Organism-specific databases

dictyBaseDDB_G0294092. cox3.

Phylogenomic databases

eggNOGCOG1845.
KOK02262.
PhylomeDBO21049.

Family and domain databases

Gene3D1.20.120.80. 2 hits.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 2 hits.
[Graphical view]
SUPFAMSSF81452. SSF81452. 2 hits.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROO21049.

Entry information

Entry nameCOX3_DICDI
AccessionPrimary (citable) accession number: O21049
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase