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Protein

Cytochrome c oxidase subunit 1+2

Gene

cox1/2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi80Iron (heme A axial ligand)By similarity1
Metal bindingi259Copper BBy similarity1
Metal bindingi263Copper BBy similarity1
Metal bindingi308Copper BBy similarity1
Metal bindingi309Copper BBy similarity1
Metal bindingi394Iron (heme A3 axial ligand)By similarity1
Metal bindingi396Iron (heme A axial ligand)By similarity1
Metal bindingi699Copper ABy similarity1
Metal bindingi734Copper ABy similarity1
Metal bindingi738Copper ABy similarity1
Metal bindingi742Copper ABy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1+2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I+II
Gene namesi
Name:cox1/2
Synonyms:cox1, coxI, Ddmco
ORF Names:DDB_G0294088
Encoded oniMitochondrion
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componenti: Mitochondrion

Organism-specific databases

dictyBaseiDDB_G0294088. cox1/2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Transmembranei253 – 273HelicalSequence analysisAdd BLAST21
Transmembranei285 – 305HelicalSequence analysisAdd BLAST21
Transmembranei329 – 349HelicalSequence analysisAdd BLAST21
Transmembranei356 – 376HelicalSequence analysisAdd BLAST21
Transmembranei390 – 410HelicalSequence analysisAdd BLAST21
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Transmembranei477 – 497HelicalSequence analysisAdd BLAST21
Transmembranei545 – 565HelicalSequence analysisAdd BLAST21
Transmembranei594 – 614HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003123831 – 764Cytochrome c oxidase subunit 1+2Add BLAST764

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki259 ↔ 2631'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliO21042.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 485COX1Add BLAST485
Regioni486 – 764COX2Add BLAST279

Sequence similaritiesi

In the N-terminal section; belongs to the heme-copper respiratory oxidase family.Curated
In the C-terminal section; belongs to the cytochrome c oxidase subunit 2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiO21042.
KOiK02256.
OMAiMISAMSA.
PhylomeDBiO21042.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.10.287.90. 1 hit.
1.20.210.10. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR000883. COX1.
IPR008972. Cupredoxin.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 2 hits.
PfamiPF00115. COX1. 1 hit.
PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81442. SSF81442. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O21042-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILEIYDKQ IAEKEGNIFI FISKWIISVD HKNIGTMYTN FSILAGIVGT
60 70 80 90 100
LLSLVIRMEL STGNMLDGDG QQYNVIVTAH GLIMIFFVVM PAMLGGFANW
110 120 130 140 150
FIPIMVGSPD VAFPRLNNIS LWLIIVSFFL LLTSSCVGIG VGTGWTVYPP
160 170 180 190 200
LSTMEYHPGH AVDVGILSLH IAGASSLLGA INFLTTVFNM KIAGLSWSKV
210 220 230 240 250
SLFVWSILIT AVLLVLSLPV LAGGLTMLIT DRNFETTFFD PIGGGDPILY
260 270 280 290 300
QHLFWFFGHP EVYILILPGF GLVSIILSKY SNKGIFGVKG MISAMSAIGF
310 320 330 340 350
LGFLVWAHHM YTVGLDVDTR AYFTAATMII AIPTGIKIFS WLATLWGGVI
360 370 380 390 400
KITTPMLFVI GFLVLFTIGG LTGVVLANGG LDISLHDTYY VVAHFHYVLS
410 420 430 440 450
MGAIFAIFAG YYYYYSIMNS TRLFGVVRYN EQLGRIHFWT MFIGVNVTFF
460 470 480 490 500
PMHFLGLAGM PRRIGDYPDA YIGWNLIASY GSLITAFGLL FFVVNIFTPY
510 520 530 540 550
IRRSVNIKNG AIILMGLDFA RDWQIGFQDP ATPIMEGIID LHNYIFFYLI
560 570 580 590 600
VVAVFIGWVM GRILWRFSYK WSYPTIGDIE IFKNFTAYNQ IIHGTVIEIV
610 620 630 640 650
WTLIPTVILY LIAIPSFTLL YAMDEIINPT VTIKIIGHQW YWSYEYGDNA
660 670 680 690 700
SNLIEFDSYM VYERDLAEGQ LRLLEVDNAM VVPVKTHIRL IITSGDVLHS
710 720 730 740 750
WAIPSFGIKV DAVPGRLNQI GLYVKREGTF YGQCSELCGV DHGFMPIKVQ
760
AVKLGEYFSK LNEK
Length:764
Mass (Da):85,501
Last modified:January 1, 1998 - v1
Checksum:iBF363A039A0BA912
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83 – 89IMIFFVV → MKVFMNC in AAB42021 (Ref. 3) Curated7
Sequence conflicti104I → II in AAB42021 (Ref. 3) Curated1
Sequence conflicti198S → P in AAB42021 (Ref. 3) Curated1
Sequence conflicti259H → D in CAA65139 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50297 Genomic DNA. Translation: BAA21123.1.
AB000109 Genomic DNA. Translation: BAA78055.1.
U87391 mRNA. Translation: AAB42021.1.
X81884 Genomic DNA. Translation: CAA57467.1.
X95896 Genomic DNA. Translation: CAA65139.1.
PIRiT43751.
RefSeqiNP_050073.1. NC_000895.1.

Genome annotation databases

GeneIDi2193894.
KEGGiddi:DidioMp06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50297 Genomic DNA. Translation: BAA21123.1.
AB000109 Genomic DNA. Translation: BAA78055.1.
U87391 mRNA. Translation: AAB42021.1.
X81884 Genomic DNA. Translation: CAA57467.1.
X95896 Genomic DNA. Translation: CAA65139.1.
PIRiT43751.
RefSeqiNP_050073.1. NC_000895.1.

3D structure databases

ProteinModelPortaliO21042.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2193894.
KEGGiddi:DidioMp06.

Organism-specific databases

dictyBaseiDDB_G0294088. cox1/2.

Phylogenomic databases

InParanoidiO21042.
KOiK02256.
OMAiMISAMSA.
PhylomeDBiO21042.

Enzyme and pathway databases

UniPathwayiUPA00705.

Miscellaneous databases

PROiO21042.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.10.287.90. 1 hit.
1.20.210.10. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR000883. COX1.
IPR008972. Cupredoxin.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 2 hits.
PfamiPF00115. COX1. 1 hit.
PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81442. SSF81442. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX1_DICDI
AccessioniPrimary (citable) accession number: O21042
Secondary accession number(s): P92625, Q23893, Q7GET3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.