Reviewed,
UniProtKB/Swiss-Prot O21042 (COX1_DICDI)
Last modified
October 13, 2009.
Version 68.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cytochrome c oxidase subunit 1+2 EC=1.9.3.1 Alternative name(s): Cytochrome c oxidase polypeptide I+II | ||||||
| Gene names |
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| Encoded on | Mitochondrion | ||||||
| Organism | Dictyostelium discoideum (Slime mold) [Complete proteome] | ||||||
| Taxonomic identifier | 44689 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium |
Protein attributes
| Sequence length | 764 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity. |
| Catalytic activity | 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O. |
| Pathway | |
| Subcellular location | |
| Sequence similarities | In the N-terminal section; belongs to the heme-copper respiratory oxidase family. In the C-terminal section; belongs to the cytochrome c oxidase subunit 2 family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 764 | 764 | Cytochrome c oxidase subunit 1+2 | PRO_0000312383 | |||||||
Regions | |||||||||||
| Transmembrane | 36 – 56 | 21 | Potential | ||||||||
| Transmembrane | 82 – 102 | 21 | Potential | ||||||||
| Transmembrane | 121 – 141 | 21 | Potential | ||||||||
| Transmembrane | 164 – 184 | 21 | Potential | ||||||||
| Transmembrane | 202 – 222 | 21 | Potential | ||||||||
| Transmembrane | 253 – 273 | 21 | Potential | ||||||||
| Transmembrane | 285 – 305 | 21 | Potential | ||||||||
| Transmembrane | 329 – 349 | 21 | Potential | ||||||||
| Transmembrane | 356 – 376 | 21 | Potential | ||||||||
| Transmembrane | 390 – 410 | 21 | Potential | ||||||||
| Transmembrane | 438 – 458 | 21 | Potential | ||||||||
| Transmembrane | 477 – 497 | 21 | Potential | ||||||||
| Transmembrane | 545 – 565 | 21 | Potential | ||||||||
| Transmembrane | 594 – 614 | 21 | Potential | ||||||||
| Region | 1 – 485 | 485 | COX1 | ||||||||
| Region | 486 – 764 | 279 | COX2 | ||||||||
Sites | |||||||||||
| Metal binding | 80 | 1 | Iron (heme A axial ligand) By similarity | ||||||||
| Metal binding | 259 | 1 | Copper B By similarity | ||||||||
| Metal binding | 263 | 1 | Copper B By similarity | ||||||||
| Metal binding | 308 | 1 | Copper B By similarity | ||||||||
| Metal binding | 309 | 1 | Copper B By similarity | ||||||||
| Metal binding | 394 | 1 | Iron (heme A3 axial ligand) By similarity | ||||||||
| Metal binding | 396 | 1 | Iron (heme A axial ligand) By similarity | ||||||||
| Metal binding | 699 | 1 | Copper A By similarity | ||||||||
| Metal binding | 734 | 1 | Copper A By similarity | ||||||||
| Metal binding | 738 | 1 | Copper A By similarity | ||||||||
| Metal binding | 742 | 1 | Copper A By similarity | ||||||||
Amino acid modifications | |||||||||||
| Cross-link | 259 ↔ 263 | 1'-histidyl-3'-tyrosine (His-Tyr) By similarity | |||||||||
Experimental info | |||||||||||
| Sequence conflict | 83 – 89 | 7 | IMIFFVV → MKVFMNC in AAB42021. Ref.3 | ||||||||
| Sequence conflict | 104 | 1 | I → II in AAB42021. Ref.3 | ||||||||
| Sequence conflict | 198 | 1 | S → P in AAB42021. Ref.3 | ||||||||
| Sequence conflict | 259 | 1 | H → D in CAA65139. Ref.5 | ||||||||
Sequences
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References
| [1] | "Group-I introns in the cytochrome c oxidase genes of Dictyostelium discoideum: two related ORFs in one loop of a group-I intron, a cox1/2 hybrid gene and an unusually large cox3 gene." Ogawa S., Matsuo K., Angata K., Yanagisawa K., Tanaka Y. Curr. Genet. 31:80-88(1997) [PubMed: 9000384] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: AX3. |
| [2] | "The mitochondrial DNA of Dictyostelium discoideum: complete sequence, gene content and genome organization." Ogawa S., Yoshino R., Angata K., Iwamoto M., Pi M., Kuroe K., Matsuo K., Morio T., Urushihara H., Yanagisawa K., Tanaka Y. Mol. Gen. Genet. 263:514-519(2000) [PubMed: 10821186] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: AX3. |
| [3] | "Dictyostelium discoideum Ddmco gene sequence." Mueller-Taubenberger A. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 83-205. Strain: AX3. |
| [4] | "Subunits I and II of Dictyostelium cytochrome c oxidase are specified by a single open reading frame transcribed into a large polycistronic RNA." Pellizzari R., Anjard C., Bisson R. Biochim. Biophys. Acta 1320:1-7(1997) [PubMed: 9186775] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 259-764. Strain: AX3. |
| [5] | Anjard C., Reymond C.D. Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 259-341. Strain: AX2. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| D50297 Genomic DNA. Translation: BAA21123.1. AB000109 Genomic DNA. Translation: BAA78055.1. U87391 mRNA. Translation: AAB42021.1. X81884 Genomic DNA. Translation: CAA57467.1. X95896 Genomic DNA. Translation: CAA65139.1. | |
| PIR | T43751. |
| RefSeq | NP_050073.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1AR1 based on UniProtKB P98002. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | O21042. |
Genome annotation databases | |
| GeneID | 2193894. |
| GenomeReviews | Gene locus cox1/2 in contig AB000109_GR. |
Organism-specific databases | |
| dictyBase | DDB_G0294088. cox1/2. |
Enzyme and pathway databases | |
| BRENDA | 1.9.3.1. 424. |
Family and domain databases | |
| InterPro | IPR001505. Copper_CuA. IPR008972. Cupredoxin. IPR011759. Cyt_c_oxidase_II_TM. IPR000883. Cyt_c_oxidase_su1. IPR014222. Cyt_c_oxidase_su2. IPR002429. Cyt_c_oxidase_su2_C. [Graphical view] |
| Gene3D | G3DSA:1.20.210.10. COX1. 1 hit. G3DSA:1.10.287.90. COX2_TM. 1 hit. G3DSA:2.60.40.420. Cupredoxin. 1 hit. |
| PANTHER | PTHR10422. COX1. 1 hit. |
| Pfam | PF00115. COX1. 1 hit. PF00116. COX2. 1 hit. PF02790. COX2_TM. 1 hit. [Graphical view] |
| PRINTS | PR01165. CYCOXIDASEI. |
| ProDom | PD000131. Copper_CuA. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR02866. CoxB. 1 hit. |
| PROSITE | PS50855. COX1. 1 hit. PS00077. COX1_CUB. 1 hit. PS00078. COX2. 1 hit. PS50857. COX2_CUA. 1 hit. PS50999. COX2_TM. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | COX1_DICDI | ||||||||
| Accession | Primary (citable) accession number: O21042 Secondary accession number(s): P92625, Q23893, Q7GET3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| Dictyostelium discoideum Dictyostelium discoideum: entries, gene names and cross-references to dictyBase |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


