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O21042

- COX1_DICDI

UniProt

O21042 - COX1_DICDI

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Protein

Cytochrome c oxidase subunit 1+2

Gene

cox1/2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi80 – 801Iron (heme A axial ligand)By similarity
Metal bindingi259 – 2591Copper BBy similarity
Metal bindingi263 – 2631Copper BBy similarity
Metal bindingi308 – 3081Copper BBy similarity
Metal bindingi309 – 3091Copper BBy similarity
Metal bindingi394 – 3941Iron (heme A3 axial ligand)By similarity
Metal bindingi396 – 3961Iron (heme A axial ligand)By similarity
Metal bindingi699 – 6991Copper ABy similarity
Metal bindingi734 – 7341Copper ABy similarity
Metal bindingi738 – 7381Copper ABy similarity
Metal bindingi742 – 7421Copper ABy similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1+2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I+II
Gene namesi
Name:cox1/2
Synonyms:cox1, coxI, Ddmco
ORF Names:DDB_G0294088
Encoded oniMitochondrion
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Mitochondrion

Organism-specific databases

dictyBaseiDDB_G0294088. cox1/2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 5621HelicalSequence AnalysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence AnalysisAdd
BLAST
Transmembranei121 – 14121HelicalSequence AnalysisAdd
BLAST
Transmembranei164 – 18421HelicalSequence AnalysisAdd
BLAST
Transmembranei202 – 22221HelicalSequence AnalysisAdd
BLAST
Transmembranei253 – 27321HelicalSequence AnalysisAdd
BLAST
Transmembranei285 – 30521HelicalSequence AnalysisAdd
BLAST
Transmembranei329 – 34921HelicalSequence AnalysisAdd
BLAST
Transmembranei356 – 37621HelicalSequence AnalysisAdd
BLAST
Transmembranei390 – 41021HelicalSequence AnalysisAdd
BLAST
Transmembranei438 – 45821HelicalSequence AnalysisAdd
BLAST
Transmembranei477 – 49721HelicalSequence AnalysisAdd
BLAST
Transmembranei545 – 56521HelicalSequence AnalysisAdd
BLAST
Transmembranei594 – 61421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 764764Cytochrome c oxidase subunit 1+2PRO_0000312383Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki259 ↔ 2631'-histidyl-3'-tyrosine (His-Tyr)By similarity

Interactioni

Protein-protein interaction databases

STRINGi44689.DidioMp06.

Structurei

3D structure databases

ProteinModelPortaliO21042.
SMRiO21042. Positions 20-494.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 485485COX1Add
BLAST
Regioni486 – 764279COX2Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the heme-copper respiratory oxidase family.Curated
In the C-terminal section; belongs to the cytochrome c oxidase subunit 2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1622.
InParanoidiO21042.
KOiK02256.
OMAiMISAMSA.
PhylomeDBiO21042.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
1.20.210.10. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR000883. COX1.
IPR008972. Cupredoxin.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81442. SSF81442. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O21042-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKILEIYDKQ IAEKEGNIFI FISKWIISVD HKNIGTMYTN FSILAGIVGT
60 70 80 90 100
LLSLVIRMEL STGNMLDGDG QQYNVIVTAH GLIMIFFVVM PAMLGGFANW
110 120 130 140 150
FIPIMVGSPD VAFPRLNNIS LWLIIVSFFL LLTSSCVGIG VGTGWTVYPP
160 170 180 190 200
LSTMEYHPGH AVDVGILSLH IAGASSLLGA INFLTTVFNM KIAGLSWSKV
210 220 230 240 250
SLFVWSILIT AVLLVLSLPV LAGGLTMLIT DRNFETTFFD PIGGGDPILY
260 270 280 290 300
QHLFWFFGHP EVYILILPGF GLVSIILSKY SNKGIFGVKG MISAMSAIGF
310 320 330 340 350
LGFLVWAHHM YTVGLDVDTR AYFTAATMII AIPTGIKIFS WLATLWGGVI
360 370 380 390 400
KITTPMLFVI GFLVLFTIGG LTGVVLANGG LDISLHDTYY VVAHFHYVLS
410 420 430 440 450
MGAIFAIFAG YYYYYSIMNS TRLFGVVRYN EQLGRIHFWT MFIGVNVTFF
460 470 480 490 500
PMHFLGLAGM PRRIGDYPDA YIGWNLIASY GSLITAFGLL FFVVNIFTPY
510 520 530 540 550
IRRSVNIKNG AIILMGLDFA RDWQIGFQDP ATPIMEGIID LHNYIFFYLI
560 570 580 590 600
VVAVFIGWVM GRILWRFSYK WSYPTIGDIE IFKNFTAYNQ IIHGTVIEIV
610 620 630 640 650
WTLIPTVILY LIAIPSFTLL YAMDEIINPT VTIKIIGHQW YWSYEYGDNA
660 670 680 690 700
SNLIEFDSYM VYERDLAEGQ LRLLEVDNAM VVPVKTHIRL IITSGDVLHS
710 720 730 740 750
WAIPSFGIKV DAVPGRLNQI GLYVKREGTF YGQCSELCGV DHGFMPIKVQ
760
AVKLGEYFSK LNEK
Length:764
Mass (Da):85,501
Last modified:January 1, 1998 - v1
Checksum:iBF363A039A0BA912
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti83 – 897IMIFFVV → MKVFMNC in AAB42021. 1 PublicationCurated
Sequence conflicti104 – 1041I → II in AAB42021. 1 PublicationCurated
Sequence conflicti198 – 1981S → P in AAB42021. 1 PublicationCurated
Sequence conflicti259 – 2591H → D in CAA65139. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50297 Genomic DNA. Translation: BAA21123.1.
AB000109 Genomic DNA. Translation: BAA78055.1.
U87391 mRNA. Translation: AAB42021.1.
X81884 Genomic DNA. Translation: CAA57467.1.
X95896 Genomic DNA. Translation: CAA65139.1.
PIRiT43751.
RefSeqiNP_050073.1. NC_000895.1.

Genome annotation databases

GeneIDi2193894.
KEGGiddi:DidioMp06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50297 Genomic DNA. Translation: BAA21123.1 .
AB000109 Genomic DNA. Translation: BAA78055.1 .
U87391 mRNA. Translation: AAB42021.1 .
X81884 Genomic DNA. Translation: CAA57467.1 .
X95896 Genomic DNA. Translation: CAA65139.1 .
PIRi T43751.
RefSeqi NP_050073.1. NC_000895.1.

3D structure databases

ProteinModelPortali O21042.
SMRi O21042. Positions 20-494.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DidioMp06.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2193894.
KEGGi ddi:DidioMp06.

Organism-specific databases

dictyBasei DDB_G0294088. cox1/2.

Phylogenomic databases

eggNOGi COG1622.
InParanoidi O21042.
KOi K02256.
OMAi MISAMSA.
PhylomeDBi O21042.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Miscellaneous databases

PROi O21042.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
1.20.210.10. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR000883. COX1.
IPR008972. Cupredoxin.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81442. SSF81442. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Group-I introns in the cytochrome c oxidase genes of Dictyostelium discoideum: two related ORFs in one loop of a group-I intron, a cox1/2 hybrid gene and an unusually large cox3 gene."
    Ogawa S., Matsuo K., Angata K., Yanagisawa K., Tanaka Y.
    Curr. Genet. 31:80-88(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: AX3.
  2. "The mitochondrial DNA of Dictyostelium discoideum: complete sequence, gene content and genome organization."
    Ogawa S., Yoshino R., Angata K., Iwamoto M., Pi M., Kuroe K., Matsuo K., Morio T., Urushihara H., Yanagisawa K., Tanaka Y.
    Mol. Gen. Genet. 263:514-519(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX3.
  3. "Dictyostelium discoideum Ddmco gene sequence."
    Mueller-Taubenberger A.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 83-205.
    Strain: AX3.
  4. "Subunits I and II of Dictyostelium cytochrome c oxidase are specified by a single open reading frame transcribed into a large polycistronic RNA."
    Pellizzari R., Anjard C., Bisson R.
    Biochim. Biophys. Acta 1320:1-7(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 259-764.
    Strain: AX3.
  5. Anjard C., Reymond C.D.
    Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 259-341.
    Strain: AX2.

Entry informationi

Entry nameiCOX1_DICDI
AccessioniPrimary (citable) accession number: O21042
Secondary accession number(s): P92625, Q23893, Q7GET3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3