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O21042

- COX1_DICDI

UniProt

O21042 - COX1_DICDI

Protein

Cytochrome c oxidase subunit 1+2

Gene

cox1/2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.By similarity

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi80 – 801Iron (heme A axial ligand)By similarity
    Metal bindingi259 – 2591Copper BBy similarity
    Metal bindingi263 – 2631Copper BBy similarity
    Metal bindingi308 – 3081Copper BBy similarity
    Metal bindingi309 – 3091Copper BBy similarity
    Metal bindingi394 – 3941Iron (heme A3 axial ligand)By similarity
    Metal bindingi396 – 3961Iron (heme A axial ligand)By similarity
    Metal bindingi699 – 6991Copper ABy similarity
    Metal bindingi734 – 7341Copper ABy similarity
    Metal bindingi738 – 7381Copper ABy similarity
    Metal bindingi742 – 7421Copper ABy similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC
    3. heme binding Source: InterPro
    4. iron ion binding Source: InterPro
    5. protein binding Source: dictyBase

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. electron transport chain Source: InterPro
    3. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1+2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I+II
    Gene namesi
    Name:cox1/2
    Synonyms:cox1, coxI, Ddmco
    ORF Names:DDB_G0294088
    Encoded oniMitochondrion
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Mitochondrion

    Organism-specific databases

    dictyBaseiDDB_G0294088. cox1/2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 764764Cytochrome c oxidase subunit 1+2PRO_0000312383Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki259 ↔ 2631'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DidioMp06.

    Structurei

    3D structure databases

    ProteinModelPortaliO21042.
    SMRiO21042. Positions 20-494.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 5621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei121 – 14121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei164 – 18421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei202 – 22221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei253 – 27321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei285 – 30521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei329 – 34921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei356 – 37621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei390 – 41021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei438 – 45821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei477 – 49721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei545 – 56521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei594 – 61421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 485485COX1Add
    BLAST
    Regioni486 – 764279COX2Add
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the heme-copper respiratory oxidase family.Curated
    In the C-terminal section; belongs to the cytochrome c oxidase subunit 2 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1622.
    KOiK02256.
    OMAiMISAMSA.
    PhylomeDBiO21042.

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    1.20.210.10. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR000883. COX1.
    IPR008972. Cupredoxin.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81442. SSF81442. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O21042-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKILEIYDKQ IAEKEGNIFI FISKWIISVD HKNIGTMYTN FSILAGIVGT    50
    LLSLVIRMEL STGNMLDGDG QQYNVIVTAH GLIMIFFVVM PAMLGGFANW 100
    FIPIMVGSPD VAFPRLNNIS LWLIIVSFFL LLTSSCVGIG VGTGWTVYPP 150
    LSTMEYHPGH AVDVGILSLH IAGASSLLGA INFLTTVFNM KIAGLSWSKV 200
    SLFVWSILIT AVLLVLSLPV LAGGLTMLIT DRNFETTFFD PIGGGDPILY 250
    QHLFWFFGHP EVYILILPGF GLVSIILSKY SNKGIFGVKG MISAMSAIGF 300
    LGFLVWAHHM YTVGLDVDTR AYFTAATMII AIPTGIKIFS WLATLWGGVI 350
    KITTPMLFVI GFLVLFTIGG LTGVVLANGG LDISLHDTYY VVAHFHYVLS 400
    MGAIFAIFAG YYYYYSIMNS TRLFGVVRYN EQLGRIHFWT MFIGVNVTFF 450
    PMHFLGLAGM PRRIGDYPDA YIGWNLIASY GSLITAFGLL FFVVNIFTPY 500
    IRRSVNIKNG AIILMGLDFA RDWQIGFQDP ATPIMEGIID LHNYIFFYLI 550
    VVAVFIGWVM GRILWRFSYK WSYPTIGDIE IFKNFTAYNQ IIHGTVIEIV 600
    WTLIPTVILY LIAIPSFTLL YAMDEIINPT VTIKIIGHQW YWSYEYGDNA 650
    SNLIEFDSYM VYERDLAEGQ LRLLEVDNAM VVPVKTHIRL IITSGDVLHS 700
    WAIPSFGIKV DAVPGRLNQI GLYVKREGTF YGQCSELCGV DHGFMPIKVQ 750
    AVKLGEYFSK LNEK 764
    Length:764
    Mass (Da):85,501
    Last modified:January 1, 1998 - v1
    Checksum:iBF363A039A0BA912
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti83 – 897IMIFFVV → MKVFMNC in AAB42021. 1 PublicationCurated
    Sequence conflicti104 – 1041I → II in AAB42021. 1 PublicationCurated
    Sequence conflicti198 – 1981S → P in AAB42021. 1 PublicationCurated
    Sequence conflicti259 – 2591H → D in CAA65139. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50297 Genomic DNA. Translation: BAA21123.1.
    AB000109 Genomic DNA. Translation: BAA78055.1.
    U87391 mRNA. Translation: AAB42021.1.
    X81884 Genomic DNA. Translation: CAA57467.1.
    X95896 Genomic DNA. Translation: CAA65139.1.
    PIRiT43751.
    RefSeqiNP_050073.1. NC_000895.1.

    Genome annotation databases

    GeneIDi2193894.
    KEGGiddi:DidioMp06.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50297 Genomic DNA. Translation: BAA21123.1 .
    AB000109 Genomic DNA. Translation: BAA78055.1 .
    U87391 mRNA. Translation: AAB42021.1 .
    X81884 Genomic DNA. Translation: CAA57467.1 .
    X95896 Genomic DNA. Translation: CAA65139.1 .
    PIRi T43751.
    RefSeqi NP_050073.1. NC_000895.1.

    3D structure databases

    ProteinModelPortali O21042.
    SMRi O21042. Positions 20-494.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DidioMp06.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2193894.
    KEGGi ddi:DidioMp06.

    Organism-specific databases

    dictyBasei DDB_G0294088. cox1/2.

    Phylogenomic databases

    eggNOGi COG1622.
    KOi K02256.
    OMAi MISAMSA.
    PhylomeDBi O21042.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Miscellaneous databases

    PROi O21042.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    1.20.210.10. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR000883. COX1.
    IPR008972. Cupredoxin.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81442. SSF81442. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Group-I introns in the cytochrome c oxidase genes of Dictyostelium discoideum: two related ORFs in one loop of a group-I intron, a cox1/2 hybrid gene and an unusually large cox3 gene."
      Ogawa S., Matsuo K., Angata K., Yanagisawa K., Tanaka Y.
      Curr. Genet. 31:80-88(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: AX3.
    2. "The mitochondrial DNA of Dictyostelium discoideum: complete sequence, gene content and genome organization."
      Ogawa S., Yoshino R., Angata K., Iwamoto M., Pi M., Kuroe K., Matsuo K., Morio T., Urushihara H., Yanagisawa K., Tanaka Y.
      Mol. Gen. Genet. 263:514-519(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX3.
    3. "Dictyostelium discoideum Ddmco gene sequence."
      Mueller-Taubenberger A.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 83-205.
      Strain: AX3.
    4. "Subunits I and II of Dictyostelium cytochrome c oxidase are specified by a single open reading frame transcribed into a large polycistronic RNA."
      Pellizzari R., Anjard C., Bisson R.
      Biochim. Biophys. Acta 1320:1-7(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 259-764.
      Strain: AX3.
    5. Anjard C., Reymond C.D.
      Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 259-341.
      Strain: AX2.

    Entry informationi

    Entry nameiCOX1_DICDI
    AccessioniPrimary (citable) accession number: O21042
    Secondary accession number(s): P92625, Q23893, Q7GET3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3