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O21042

- COX1_DICDI

UniProt

O21042 - COX1_DICDI

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Protein
Cytochrome c oxidase subunit 1+2
Gene
cox1/2, cox1, coxI, Ddmco, DDB_G0294088
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi80 – 801Iron (heme A axial ligand) By similarity
Metal bindingi259 – 2591Copper B By similarity
Metal bindingi263 – 2631Copper B By similarity
Metal bindingi308 – 3081Copper B By similarity
Metal bindingi309 – 3091Copper B By similarity
Metal bindingi394 – 3941Iron (heme A3 axial ligand) By similarity
Metal bindingi396 – 3961Iron (heme A axial ligand) By similarity
Metal bindingi699 – 6991Copper A By similarity
Metal bindingi734 – 7341Copper A By similarity
Metal bindingi738 – 7381Copper A By similarity
Metal bindingi742 – 7421Copper A By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro
  5. protein binding Source: dictyBase

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1+2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I+II
Gene namesi
Name:cox1/2
Synonyms:cox1, coxI, Ddmco
ORF Names:DDB_G0294088
Encoded oniMitochondrion
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Mitochondrion

Organism-specific databases

dictyBaseiDDB_G0294088. cox1/2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 5621Helical; Reviewed prediction
Add
BLAST
Transmembranei82 – 10221Helical; Reviewed prediction
Add
BLAST
Transmembranei121 – 14121Helical; Reviewed prediction
Add
BLAST
Transmembranei164 – 18421Helical; Reviewed prediction
Add
BLAST
Transmembranei202 – 22221Helical; Reviewed prediction
Add
BLAST
Transmembranei253 – 27321Helical; Reviewed prediction
Add
BLAST
Transmembranei285 – 30521Helical; Reviewed prediction
Add
BLAST
Transmembranei329 – 34921Helical; Reviewed prediction
Add
BLAST
Transmembranei356 – 37621Helical; Reviewed prediction
Add
BLAST
Transmembranei390 – 41021Helical; Reviewed prediction
Add
BLAST
Transmembranei438 – 45821Helical; Reviewed prediction
Add
BLAST
Transmembranei477 – 49721Helical; Reviewed prediction
Add
BLAST
Transmembranei545 – 56521Helical; Reviewed prediction
Add
BLAST
Transmembranei594 – 61421Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 764764Cytochrome c oxidase subunit 1+2
PRO_0000312383Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki259 ↔ 2631'-histidyl-3'-tyrosine (His-Tyr) By similarity

Interactioni

Protein-protein interaction databases

STRINGi44689.DidioMp06.

Structurei

3D structure databases

ProteinModelPortaliO21042.
SMRiO21042. Positions 20-494.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 485485COX1
Add
BLAST
Regioni486 – 764279COX2
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the heme-copper respiratory oxidase family.
In the C-terminal section; belongs to the cytochrome c oxidase subunit 2 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1622.
KOiK02256.
OMAiMISAMSA.
PhylomeDBiO21042.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
1.20.210.10. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR000883. COX1.
IPR008972. Cupredoxin.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81442. SSF81442. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O21042-1 [UniParc]FASTAAdd to Basket

« Hide

MKILEIYDKQ IAEKEGNIFI FISKWIISVD HKNIGTMYTN FSILAGIVGT    50
LLSLVIRMEL STGNMLDGDG QQYNVIVTAH GLIMIFFVVM PAMLGGFANW 100
FIPIMVGSPD VAFPRLNNIS LWLIIVSFFL LLTSSCVGIG VGTGWTVYPP 150
LSTMEYHPGH AVDVGILSLH IAGASSLLGA INFLTTVFNM KIAGLSWSKV 200
SLFVWSILIT AVLLVLSLPV LAGGLTMLIT DRNFETTFFD PIGGGDPILY 250
QHLFWFFGHP EVYILILPGF GLVSIILSKY SNKGIFGVKG MISAMSAIGF 300
LGFLVWAHHM YTVGLDVDTR AYFTAATMII AIPTGIKIFS WLATLWGGVI 350
KITTPMLFVI GFLVLFTIGG LTGVVLANGG LDISLHDTYY VVAHFHYVLS 400
MGAIFAIFAG YYYYYSIMNS TRLFGVVRYN EQLGRIHFWT MFIGVNVTFF 450
PMHFLGLAGM PRRIGDYPDA YIGWNLIASY GSLITAFGLL FFVVNIFTPY 500
IRRSVNIKNG AIILMGLDFA RDWQIGFQDP ATPIMEGIID LHNYIFFYLI 550
VVAVFIGWVM GRILWRFSYK WSYPTIGDIE IFKNFTAYNQ IIHGTVIEIV 600
WTLIPTVILY LIAIPSFTLL YAMDEIINPT VTIKIIGHQW YWSYEYGDNA 650
SNLIEFDSYM VYERDLAEGQ LRLLEVDNAM VVPVKTHIRL IITSGDVLHS 700
WAIPSFGIKV DAVPGRLNQI GLYVKREGTF YGQCSELCGV DHGFMPIKVQ 750
AVKLGEYFSK LNEK 764
Length:764
Mass (Da):85,501
Last modified:January 1, 1998 - v1
Checksum:iBF363A039A0BA912
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti83 – 897IMIFFVV → MKVFMNC in AAB42021. 1 Publication
Sequence conflicti104 – 1041I → II in AAB42021. 1 Publication
Sequence conflicti198 – 1981S → P in AAB42021. 1 Publication
Sequence conflicti259 – 2591H → D in CAA65139. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50297 Genomic DNA. Translation: BAA21123.1.
AB000109 Genomic DNA. Translation: BAA78055.1.
U87391 mRNA. Translation: AAB42021.1.
X81884 Genomic DNA. Translation: CAA57467.1.
X95896 Genomic DNA. Translation: CAA65139.1.
PIRiT43751.
RefSeqiNP_050073.1. NC_000895.1.

Genome annotation databases

GeneIDi2193894.
KEGGiddi:DidioMp06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50297 Genomic DNA. Translation: BAA21123.1 .
AB000109 Genomic DNA. Translation: BAA78055.1 .
U87391 mRNA. Translation: AAB42021.1 .
X81884 Genomic DNA. Translation: CAA57467.1 .
X95896 Genomic DNA. Translation: CAA65139.1 .
PIRi T43751.
RefSeqi NP_050073.1. NC_000895.1.

3D structure databases

ProteinModelPortali O21042.
SMRi O21042. Positions 20-494.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DidioMp06.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2193894.
KEGGi ddi:DidioMp06.

Organism-specific databases

dictyBasei DDB_G0294088. cox1/2.

Phylogenomic databases

eggNOGi COG1622.
KOi K02256.
OMAi MISAMSA.
PhylomeDBi O21042.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Miscellaneous databases

PROi O21042.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
1.20.210.10. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR000883. COX1.
IPR008972. Cupredoxin.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81442. SSF81442. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Group-I introns in the cytochrome c oxidase genes of Dictyostelium discoideum: two related ORFs in one loop of a group-I intron, a cox1/2 hybrid gene and an unusually large cox3 gene."
    Ogawa S., Matsuo K., Angata K., Yanagisawa K., Tanaka Y.
    Curr. Genet. 31:80-88(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: AX3.
  2. "The mitochondrial DNA of Dictyostelium discoideum: complete sequence, gene content and genome organization."
    Ogawa S., Yoshino R., Angata K., Iwamoto M., Pi M., Kuroe K., Matsuo K., Morio T., Urushihara H., Yanagisawa K., Tanaka Y.
    Mol. Gen. Genet. 263:514-519(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX3.
  3. "Dictyostelium discoideum Ddmco gene sequence."
    Mueller-Taubenberger A.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 83-205.
    Strain: AX3.
  4. "Subunits I and II of Dictyostelium cytochrome c oxidase are specified by a single open reading frame transcribed into a large polycistronic RNA."
    Pellizzari R., Anjard C., Bisson R.
    Biochim. Biophys. Acta 1320:1-7(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 259-764.
    Strain: AX3.
  5. Anjard C., Reymond C.D.
    Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 259-341.
    Strain: AX2.

Entry informationi

Entry nameiCOX1_DICDI
AccessioniPrimary (citable) accession number: O21042
Secondary accession number(s): P92625, Q23893, Q7GET3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi