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Protein

Cytochrome c oxidase subunit 1

Gene

cox1

Organism
Crypthecodinium cohnii (Dinoflagellate) (Glenodinium cohnii)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Electron transport, Respiratory chainUniRule annotation, Transport

Keywords - Ligandi

CopperUniRule annotation, HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Name:cox1Imported
Encoded oniMitochondrionImported
OrganismiCrypthecodinium cohnii (Dinoflagellate) (Glenodinium cohnii)Imported
Taxonomic identifieri2866 [NCBI]
Taxonomic lineageiEukaryotaAlveolataDinophyceaeGonyaulacalesCrypthecodiniaceaeCrypthecodinium

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei28 – 5225HelicalSequence analysisAdd
BLAST
Transmembranei72 – 9928HelicalSequence analysisAdd
BLAST
Transmembranei111 – 13121HelicalSequence analysisAdd
BLAST
Transmembranei161 – 18626HelicalSequence analysisAdd
BLAST
Transmembranei198 – 22528HelicalSequence analysisAdd
BLAST
Transmembranei258 – 27619HelicalSequence analysisAdd
BLAST
Transmembranei288 – 30518HelicalSequence analysisAdd
BLAST
Transmembranei317 – 33519HelicalSequence analysisAdd
BLAST
Transmembranei356 – 37621HelicalSequence analysisAdd
BLAST
Transmembranei388 – 41225HelicalSequence analysisAdd
BLAST
Transmembranei433 – 45220HelicalSequence analysisAdd
BLAST
Transmembranei472 – 49120HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO20628.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 491484COX1InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O20628-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQTFVCWTL CPTFISSVKN CNHKGLGIYY LLSSFIFGIS GTLISVLIRI
60 70 80 90 100
ELYSSGNRIL SPENQNFYNI KITLHGFLMI FYLVMPGLFG GFGNYFIVIF
110 120 130 140 150
QGSPEVVYPR VNNFSILILS LSYLLLILSI ISEFGGGTGW TLYPPLSTSF
160 170 180 190 200
MNLSPSSIGN IIFGLLISGI SSVLTSLNFW ITILSLRSIG ITLKTISLFP
210 220 230 240 250
WSLLITSGML LLTLPILTGA LLMILSDINY NTLFFDPIFG GDPIFYQHLF
260 270 280 290 300
WFFGHPEVYI LIIPAFGIIS IIISGILQKI IFGNPSMIFA MSCISLLGSV
310 320 330 340 350
VWGHHMYTIG LETDTRSYFS GVTILISLPT GTKIFNWLST YLGNPSLLLL
360 370 380 390 400
KTNSSLFGLL FLLMFTIGGS TGIIIGNAAV DLGLHDTYYI IAHFHFVLSL
410 420 430 440 450
GAVIAIFSGI IFNIEKIIGS KNILPSCSSN NSFYNLVLTF IGILITFGPM
460 470 480 490 500
HFLGFNVMPR RIPDFPDSFI SWNFLSSIGS GITLLSFGFL FKFNCWITSL
510 520 530
AQCSRLFLGH VAKNIFINQT ARELIIVGLY AQHMFG
Length:536
Mass (Da):59,328
Last modified:January 1, 1998 - v1
Checksum:iAA6BB4C821BD2C61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF186994 Genomic DNA. Translation: AAB69658.1.
PIRiT07946.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF186994 Genomic DNA. Translation: AAB69658.1.
PIRiT07946.

3D structure databases

ProteinModelPortaliO20628.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO20628_CRYCO
AccessioniPrimary (citable) accession number: O20628
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: July 6, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.