O19998 (HO_RHOVL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Heme oxygenase
EC=1.14.99.3

Gene names

Name:

pbsA

Encoded on

Plastid; Chloroplast

Organism

Rhodella violacea (Red alga)

Taxonomic identifier

2801 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Rhodophyta › Rhodellophyceae › Rhodellales › Rhodellaceae › Rhodella

Protein attributes

Sequence length	235 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the opening of the heme ring with the release of iron. Key enzyme in the synthesis of the chromophoric part of the photosynthetic antennae.
Catalytic activity	Heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.
Subcellular location	Plastid › chloroplast.
Sequence similarities	Belongs to the heme oxygenase family.

Ontologies

Keywords
Biological process	Photosynthesis
Cellular component	Chloroplast Plastid
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	heme oxidation Inferred from electronic annotation. Source: InterPro photosynthesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	chloroplast Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	heme oxygenase (decyclizing) activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 235	235	Heme oxygenase		PRO_0000209700
Sites
	Metal binding	19	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	O19998 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: F0E797F8D5B72845	FASTA	235	27,144
	10 20 30 40 50 60 MIYDTNLALQ LRQGTTKAHS MAENVSFVKS FLGGVVDKQA YRQLIANFYF VYSAIEDEMK 70 80 90 100 110 120 RHQESQIIKP IYFEELNRKS SLEEDLQFYY GLEWQDKIFP SPATKVYINR IHEISNTSPE 130 140 150 160 170 180 LLIAHCYTRY LGDLSGGQIL KKITQSAMNL SGGEGTAFYE FKDIKDEKNF KQNYRLALDS 190 200 210 220 230 IHLSDSAIKS IVSEANIAFK LNMKIFQELN SNFIKIIAIF LFNFIKRIKL PGFKS

References

[1]	"The heme oxygenase gene (pbsA) in the red alga Rhodella violacea is discontinuous and transcriptionally activated during iron limitation." Richaud C., Zabulon G. Proc. Natl. Acad. Sci. U.S.A. 94:11736-11741(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF000719, AF000717, AF000718 Genomic DNA. Translation: AAB66516.1.
3D structure databases
ProteinModelPortal	O19998.
SMR	O19998. Positions 5-225.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.20.910.10. 1 hit.
InterPro	IPR002051. Haem_Oase. IPR016053. Haem_Oase-like. IPR016084. Haem_Oase-like_multi-hlx. IPR018207. Haem_oxygenase_CS. [Graphical view]
PANTHER	PTHR10720. PTHR10720. 1 hit.
Pfam	PF01126. Heme_oxygenase. 1 hit. [Graphical view]
PIRSF	PIRSF000343. Haem_Oase. 1 hit.
PRINTS	PR00088. HAEMOXYGNASE.
SUPFAM	SSF48613. Heme_oxygenase. 1 hit.
PROSITE	PS00593. HEME_OXYGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HO_RHOVL

Accession

Primary (citable) accession number: O19998

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	January 1, 1998
Last modified:	April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)