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O19908

- GLMS_CYACA

UniProt

O19908 - GLMS_CYACA

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, gcaA
Organism
Cyanidium caldarium
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei616 – 6161For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Synonyms:gcaA
Encoded oniPlastid; Chloroplast
OrganismiCyanidium caldarium
Taxonomic identifieri2771 [NCBI]
Taxonomic lineageiEukaryotaRhodophytaBangiophyceaeCyanidialesCyanidiaceaeCyanidium

Subcellular locationi

GO - Cellular componenti

  1. chloroplast Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 621620Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135421Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO19908.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 223222Glutamine amidotransferase type-2
Add
BLAST
Domaini289 – 436148SIS 1
Add
BLAST
Domaini470 – 611142SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O19908-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIIGYVGE GSCRDVLING LDKLSYRGYD SAGIAFIKNS KINVVRSKGR    50
IEKLKEKIND NFQKFEIGNI GIGHTRWATH GEPTEINAHP HLDAEGQFAV 100
VQNGVIENYV QLKNYLTVNG TYFLSDTDAE VIPHLIAYKQ KHLKLQIVEA 150
ILCALSELKG NFSTVIIARD MPDSIFVYQN KTALTLGKGS NFYSVSSDPI 200
ALIPYTKNFI QLHDRELGII SISQLAIYNK GKFTYPSRRF KANLNDLITN 250
KASFDSYTLK EIHDQKKVLR NLIISTLQSE KSIDESGQLH LEYKKIKNFQ 300
IIACGSSFNA ALVGKVILEK LIRIPVHVYY GSEFKTNLPP LLPCTLTIAV 350
SQSGETGDML SAIEIEKSRR KFQNTVYKPY LLSITNKNYS SITKKTAQSI 400
DLKAGIEIGV AATKTFTAQT LSFYLLALKL AEHKFTLRKK EINKHLDEIR 450
NLPKAIAHLL IKDESSIKWL SKQLKEISKC FYIGKGLNLG SALEGALKLK 500
EISYIHCDGY AAGEIKHGPI ALVENNTLII TITDPEQSQE STFASSQEAK 550
ARGAVLLAIT HIEDSSIYQT FDFIIKIPKI SQICASITSS VSLQLFAYYM 600
AYYKGNDIDK PRNLAKSVTV E 621
Length:621
Mass (Da):69,302
Last modified:January 23, 2007 - v3
Checksum:i64718F4EBB9E8B69
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF022186 Genomic DNA. Translation: AAB82681.1.
PIRiT11976.
RefSeqiNP_045080.1. NC_001840.1.

Genome annotation databases

GeneIDi800239.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF022186 Genomic DNA. Translation: AAB82681.1 .
PIRi T11976.
RefSeqi NP_045080.1. NC_001840.1.

3D structure databases

ProteinModelPortali O19908.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 800239.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The structure and gene repertoire of an ancient red algal plastid genome."
    Gloeckner G., Rosenthal A., Valentin K.-U.
    J. Mol. Evol. 51:382-390(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RK-1.

Entry informationi

Entry nameiGLMS_CYACA
AccessioniPrimary (citable) accession number: O19908
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 72 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3