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O19889 (SUMT_CYACA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uroporphyrinogen-III C-methyltransferase

Short name=Urogen III methylase
EC=2.1.1.107
Alternative name(s):
SUMT
Uroporphyrinogen III methylase
Short name=UROM
Gene names
Name:cobA
Encoded onPlastid; Chloroplast
OrganismCyanidium caldarium
Taxonomic identifier2771 [NCBI]
Taxonomic lineageEukaryotaRhodophytaBangiophyceaeCyanidialesCyanidiaceaeCyanidium

Protein attributes

Sequence length251 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin By similarity.

Catalytic activity

S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.

S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.

Pathway

Cofactor biosynthesis; adenosylcobalamin biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1.

Porphyrin-containing compound metabolism; siroheme biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1.

Subcellular location

Plastidchloroplast.

Sequence similarities

Belongs to the precorrin methyltransferase family.

Ontologies

Keywords
   Biological processCobalamin biosynthesis
Porphyrin biosynthesis
   Cellular componentChloroplast
Plastid
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
Gene Ontology (GO)
   Biological_processcobalamin biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

siroheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentchloroplast

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprecorrin-2 dehydrogenase activity

Inferred from electronic annotation. Source: InterPro

uroporphyrin-III C-methyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 251251Uroporphyrinogen-III C-methyltransferase
PRO_0000150376

Regions

Region93 – 953S-adenosyl-L-methionine binding By similarity

Sites

Binding site171S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding site1231S-adenosyl-L-methionine By similarity
Binding site1771S-adenosyl-L-methionine; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
O19889 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 86F8734B91F94A76

FASTA25128,126
        10         20         30         40         50         60 
MTHNKTIKKV YIVGAGPGDP ELLTLKAQRV LREADVVIYD ALVNPEILQH CKPNAEIIKV 

        70         80         90        100        110        120 
GKRRNNHSFS QLQIASLLID RAKKGERVIR LKGGDPLIFG RLGEEILELF SKNIEIEIIP 

       130        140        150        160        170        180 
GITSAFAVAA DMKFPLTHRQ LGSSITFLTG EEFYEKTTNK LKWERIIWGA DTIIVYMILY 

       190        200        210        220        230        240 
NLPKIIKKFL SVGYSAEKPI VLVQWASLKK KNFLIGTIGT IIHQVIESKF GPPSLAIIGE 

       250 
VIEISSIIQK L 

« Hide

References

[1]"The structure and gene repertoire of an ancient red algal plastid genome."
Gloeckner G., Rosenthal A., Valentin K.-U.
J. Mol. Evol. 51:382-390(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RK-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF022186 Genomic DNA. Translation: AAB82700.1.
PIRT11957.
RefSeqNP_045061.1. NC_001840.1.

3D structure databases

ProteinModelPortalO19889.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID800259.

Phylogenomic databases

ProtClustDBCLSC624849.

Enzyme and pathway databases

UniPathwayUPA00148; UER00211.
UPA00262; UER00211.

Family and domain databases

Gene3D3.30.950.10. 1 hit.
3.40.1010.10. 1 hit.
InterProIPR000878. 4pyrrol_Mease.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
IPR006366. CobA/CysG_C.
IPR003043. Uropor_MeTrfase_CS.
[Graphical view]
PfamPF00590. TP_methylase. 1 hit.
[Graphical view]
SUPFAMSSF53790. SSF53790. 1 hit.
TIGRFAMsTIGR01469. cobA_cysG_Cterm. 1 hit.
PROSITEPS00839. SUMT_1. 1 hit.
PS00840. SUMT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSUMT_CYACA
AccessionPrimary (citable) accession number: O19889
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 1, 1998
Last modified: October 16, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways