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O19741

- O19741_HUMAN

UniProt

O19741 - O19741_HUMAN

Protein
Submitted name:

HLA-DRB3 protein

Gene

HLA-DRB3

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Biological processi

    1. antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
    2. immune response Source: InterPro

    Keywords - Biological processi

    Immunity

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    HLA-DRB3 proteinImported
    Gene namesi
    Name:HLA-DRB3Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. MHC class II protein complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, MHC IIUniRule annotation

    Expressioni

    Gene expression databases

    ArrayExpressiO19741.
    BgeeiO19741.

    Structurei

    3D structure databases

    ProteinModelPortaliO19741.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    TransmembraneUniRule annotation

    Family and domain databases

    Gene3Di3.10.320.10. 1 hit.
    InterProiIPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR000353. MHC_II_b_N.
    [Graphical view]
    PfamiPF00969. MHC_II_beta. 1 hit.
    [Graphical view]
    ProDomiPD000328. MHC_II_b_N. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00921. MHC_II_beta. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    O19741-1 [UniParc]FASTAAdd to Basket

    « Hide

    RDSPEDFVFQ FKGMCYFTNG TERVRLVTRY IYNREEYARF DSDVGVYRAV   50
    TPQGRPDAEY WNSQKEVLEG TRAELDTVCR HNYEVAFRGI LQRR 94
    Length:94
    Mass (Da):11,240
    Last modified:January 1, 1998 - v1
    Checksum:i64C56873EB5597DB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei94 – 941Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M22550 mRNA. Translation: AAA59821.1.
    UniGeneiHs.409934.
    Hs.534322.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M22550 mRNA. Translation: AAA59821.1 .
    UniGenei Hs.409934.
    Hs.534322.

    3D structure databases

    ProteinModelPortali O19741.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Gene expression databases

    ArrayExpressi O19741.
    Bgeei O19741.

    Family and domain databases

    Gene3Di 3.10.320.10. 1 hit.
    InterProi IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR000353. MHC_II_b_N.
    [Graphical view ]
    Pfami PF00969. MHC_II_beta. 1 hit.
    [Graphical view ]
    ProDomi PD000328. MHC_II_b_N. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00921. MHC_II_beta. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Polymorphism of the HLA-D region in American blacks. A DR3 haplotype generated by recombination."
      Hurley C.K., Gregersen P., Steiner N., Bell J., Hartzman R., Nepom G., Silver J., Johnson A.H.
      J. Immunol. 140:885-892(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiO19741_HUMAN
    AccessioniPrimary (citable) accession number: O19741
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 1, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.