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O19741

- O19741_HUMAN

UniProt

O19741 - O19741_HUMAN

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Protein
Submitted name:

HLA-DRB3 protein

Gene

HLA-DRB3

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
  2. immune response Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Submitted name:
HLA-DRB3 proteinImported
Gene namesi
Name:HLA-DRB3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. MHC class II protein complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC IIUniRule annotation

Expressioni

Gene expression databases

BgeeiO19741.
ExpressionAtlasiO19741. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliO19741.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

TransmembraneUniRule annotation

Family and domain databases

Gene3Di3.10.320.10. 1 hit.
InterProiIPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.

Sequencei

Sequence statusi: Fragment.

O19741 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
RDSPEDFVFQ FKGMCYFTNG TERVRLVTRY IYNREEYARF DSDVGVYRAV
60 70 80 90
TPQGRPDAEY WNSQKEVLEG TRAELDTVCR HNYEVAFRGI LQRR
Length:94
Mass (Da):11,240
Last modified:January 1, 1998 - v1
Checksum:i64C56873EB5597DB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei94 – 941Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M22550 mRNA. Translation: AAA59821.1.
UniGeneiHs.409934.
Hs.534322.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M22550 mRNA. Translation: AAA59821.1 .
UniGenei Hs.409934.
Hs.534322.

3D structure databases

ProteinModelPortali O19741.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Gene expression databases

Bgeei O19741.
ExpressionAtlasi O19741. baseline and differential.

Family and domain databases

Gene3Di 3.10.320.10. 1 hit.
InterProi IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view ]
Pfami PF00969. MHC_II_beta. 1 hit.
[Graphical view ]
ProDomi PD000328. MHC_II_b_N. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00921. MHC_II_beta. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Polymorphism of the HLA-D region in American blacks. A DR3 haplotype generated by recombination."
    Hurley C.K., Gregersen P., Steiner N., Bell J., Hartzman R., Nepom G., Silver J., Johnson A.H.
    J. Immunol. 140:885-892(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO19741_HUMAN
AccessioniPrimary (citable) accession number: O19741
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.