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Protein
Submitted name:

MHC class II HLA-DQ-beta-1

Gene

HLA-DQB1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei60MannoseCombined sources1
Binding sitei64MannoseCombined sources1

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class II HLA-DQ-beta-1Imported
Gene namesi
Name:HLA-DQB1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, MHC IISAAS annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi15 ↔ 79Combined sources
Glycosylationi19N-linked (GlcNAc...)Combined sources1
Disulfide bondi117 ↔ 173Combined sources

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PeptideAtlasiO19707

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Z7UX-ray2.70B/D1-192[»]
4Z7VX-ray2.65B/D1-192[»]
4Z7WX-ray2.89B/D1-192[»]
5UJTX-ray1.94B/E/H3-191[»]
ProteinModelPortaliO19707
SMRiO19707
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 201Ig-likeInterPro annotationAdd BLAST105

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 21Fucose bindingCombined sources3

Sequence similaritiesi

Belongs to the MHC class II family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG012730

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR000353 MHC_II_b_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00969 MHC_II_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000328 MHC_II_b_N, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00921 MHC_II_beta, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Fragment.

O19707-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RDSPEDFVYQ FKGMCYFTNG TERVRLVTRY IYNREEYARF DSDVGVYRAV
60 70 80 90 100
TPLGPPAAEY WNSQKEVLER TRAELDTVCR HNYQLELRTT LQRRVEPTVT
110 120 130 140 150
ISPSRTEALN HHNLLVCSVT DFYPAQIKVR WFRNDQEETT GVVSTPLIRN
160 170 180 190 200
GDWTFQILVM LEMTPQRGDV YTCHVEHPSL QNPIIVEWRA QSESAQSKML
210 220
SGIGGFVLGL IFLGLGLIIH HRSQKGLLH
Length:229
Mass (Da):26,489
Last modified:January 1, 1998 - v1
Checksum:i9424CC5558AF92DF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34097 mRNA Translation: AAC41965.1
UniGeneiHs.409934
Hs.534322

Similar proteinsi

Entry informationi

Entry nameiO19707_HUMAN
AccessioniPrimary (citable) accession number: O19707
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: February 28, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

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