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Protein
Submitted name:

MHC class II HLA-DQ-beta-1

Gene

HLA-DQB1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
  2. immune response Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class II HLA-DQ-beta-1Imported
Gene namesi
Name:HLA-DQB1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. MHC class II protein complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC IIUniRule annotationSAAS annotation

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliO19707.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG012730.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

O19707-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RDSPEDFVYQ FKGMCYFTNG TERVRLVTRY IYNREEYARF DSDVGVYRAV
60 70 80 90 100
TPLGPPAAEY WNSQKEVLER TRAELDTVCR HNYQLELRTT LQRRVEPTVT
110 120 130 140 150
ISPSRTEALN HHNLLVCSVT DFYPAQIKVR WFRNDQEETT GVVSTPLIRN
160 170 180 190 200
GDWTFQILVM LEMTPQRGDV YTCHVEHPSL QNPIIVEWRA QSESAQSKML
210 220
SGIGGFVLGL IFLGLGLIIH HRSQKGLLH
Length:229
Mass (Da):26,489
Last modified:January 1, 1998 - v1
Checksum:i9424CC5558AF92DF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34097 mRNA. Translation: AAC41965.1.
UniGeneiHs.409934.
Hs.534322.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34097 mRNA. Translation: AAC41965.1.
UniGeneiHs.409934.
Hs.534322.

3D structure databases

ProteinModelPortaliO19707.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG012730.

Miscellaneous databases

ChiTaRSiHLA-DQB1. human.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Different contribution of HLA-DR and -DQ genes in susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM)."
    Yasunaga S., Kimura A., Hamaguchi K., Ronningen K.S., Sasazuki T.
    Tissue Antigens 47:37-48(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO19707_HUMAN
AccessioniPrimary (citable) accession number: O19707
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: March 4, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.