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Protein
Submitted name:

HLA-E

Gene

HLA-E

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
HLA-EImported
Gene namesi
Name:HLA-EImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei65 – 9127HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiO19682.
PRIDEiO19682.

Expressioni

Gene expression databases

BgeeiO19682.
GenevisibleiO19682. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000365817.

Structurei

3D structure databases

ProteinModelPortaliO19682.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 5252IGc1InterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410JD1V. Eukaryota.
ENOG410YKQA. LUCA.
HOVERGENiHBG016709.
KOiK06751.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

O19682-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QQDGEGHTQD TELVETRPAG DGTFQKWAAV VVPSGEEQRY TCHVQHEGLP
60 70 80 90 100
EPVTLRWKPA SQPTIPIVGI IAGLVLLGSV VSGAVVAAVI WRKKSSGGKG
110 120
GSYSKAEWSD SAQGSESHSL
Length:120
Mass (Da):12,662
Last modified:January 1, 1998 - v1
Checksum:iD72D65787AB98847
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56841 mRNA. Translation: CAA40172.1.
PIRiA28834.
RefSeqiNP_005507.3. NM_005516.5.
UniGeneiHs.650174.

Genome annotation databases

GeneIDi3133.
KEGGihsa:3133.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56841 mRNA. Translation: CAA40172.1.
PIRiA28834.
RefSeqiNP_005507.3. NM_005516.5.
UniGeneiHs.650174.

3D structure databases

ProteinModelPortaliO19682.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000365817.

Proteomic databases

PaxDbiO19682.
PRIDEiO19682.

Protocols and materials databases

DNASUi3133.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3133.
KEGGihsa:3133.

Organism-specific databases

CTDi3133.

Phylogenomic databases

eggNOGiENOG410JD1V. Eukaryota.
ENOG410YKQA. LUCA.
HOVERGENiHBG016709.
KOiK06751.

Miscellaneous databases

ChiTaRSiHLA-E. human.
GenomeRNAii3133.
NextBioi12427.

Gene expression databases

BgeeiO19682.
GenevisibleiO19682. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and expression of a cDNA encoding a non-classical MHC class I antigen (HLA-E) in eosinophils from hypereosinophilic patients."
    Truong M.J., Gruart V., Capron A., Capron M., Tourvieille B.
    J. Immunol. 148:627-632(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BloodImported.

Entry informationi

Entry nameiO19682_HUMAN
AccessioniPrimary (citable) accession number: O19682
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: December 9, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.