O19678 (O19678_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
HLA-DRB4 protein EMBL AAA58651.1

Gene names

Name:

HLA-DRB4 EMBL AAA58651.1

Organism

Homo sapiens (Human) EMBL AAA58651.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	220 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 Ig-like C1-type (immunoglobulin-like) domain. SAAS SAAS003597

Ontologies

Keywords
Biological process	Immunity
Cellular component	MHC II SAAS SAAS003597 RuleBase RU000321 Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS014745
Gene Ontology (GO)
Biological_process	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Inferred from electronic annotation. Source: UniProtKB-KW immune response Inferred from electronic annotation. Source: InterPro
Cellular_component	MHC class II protein complex Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	220	1	EMBL AAA58651.1

Sequences

	Sequence		Length	Mass (Da)
	O19678 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 069781B7001B553E	FASTA	220	25,427
	10 20 30 40 50 60 RFLEYSTSEC HFFNGTERVR YLDRYFHNQE ENVRFDSDVG EFRAVTELGR PDAEYWNSQK 70 80 90 100 110 120 DLLEQKRGRV DNYCRHNYGV VESFTVQRRV HPKVTVYPSK TQPLQHHNLL VCSVSGFYPG 130 140 150 160 170 180 SIEVRWFRNG QEEKTGVVST GLIHNGDWTF QTLVMLETVP RSGEVYTCQV EHPSVTSPLT 190 200 210 220 VEWRARSESA QSKMLSGVGG FVLGLLFLGA GLFIYFRNQK

References

[1]	"Characterization of three HLA-DR beta genes isolated from an HLA-DR 3/4 insulin-dependent diabetic patient." Owerbach D., Rich C., Taneja K. Immunogenetics 24:41-46(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M15839, M15373, M15377 Genomic DNA. Translation: AAA58651.1.
IPI	IPI00473139.
PIR	C60748. F60748. I68710.
UniGene	Hs.485130. Hs.534322. Hs.696211. Hs.736560.
3D structure databases
HSSP	HSSP built from PDB template 1A6A based on UniProtKB P01912.
ProteinModelPortal	O19678.
ModBase	Search...
Protein-protein interaction databases
STRING	O19678.
Proteomic databases
PRIDE	O19678.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG012730.
Gene expression databases
ArrayExpress	O19678.
Family and domain databases
Gene3D	2.60.40.10. 1 hit. 3.10.320.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR003597. Ig_C1-set. IPR011162. MHC_I/II-like_Ag-recog. IPR014745. MHC_II_a/b_N. IPR000353. MHC_II_b_N. [Graphical view]
Pfam	PF07654. C1-set. 1 hit. PF00969. MHC_II_beta. 1 hit. [Graphical view]
ProDom	PD000328. MHC_II_b_N. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00407. IGc1. 1 hit. SM00921. MHC_II_beta. 1 hit. [Graphical view]
SUPFAM	SSF54452. MHC_I/II-like_Ag-recog. 1 hit.
PROSITE	PS50835. IG_LIKE. 1 hit. PS00290. IG_MHC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O19678_HUMAN

Accession

Primary (citable) accession number: O19678

Entry history

Integrated into UniProtKB/TrEMBL:	January 1, 1998
Last sequence update:	January 1, 1998
Last modified:	April 3, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.