ID   O19617_HUMAN            Unreviewed;       366 AA.
AC   O19617; A0A090KMD8;
DT   01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT   01-JAN-1998, sequence version 1.
DT   27-MAR-2024, entry version 205.
DE   SubName: Full=HLA class I antigen {ECO:0000313|EMBL:BAA22206.1};
DE   SubName: Full=HLA class I histocompatibility antigen, C alpha chain {ECO:0000313|Ensembl:ENSP00000414063.2};
DE   SubName: Full=MHC class I antigen {ECO:0000313|EMBL:ANZ73061.1};
DE   SubName: Full=Major histocompatibility complex, class I, C {ECO:0000313|EMBL:AAH33293.1};
GN   Name=HLA-C {ECO:0000313|EMBL:BAA22206.1,
GN   ECO:0000313|Ensembl:ENSP00000414063.2};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAA22206.1};
RN   [1] {ECO:0000313|EMBL:BAA22206.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=9177776; DOI=10.1006/geno.1997.4708;
RA   Mizuki N., Ando H., Kimura M., Ohno S., Miyata S., Yamazaki M., Tashiro H.,
RA   Watanabe K., Ono A., Taguchi S., Sugawara C., Fukuzumi Y., Okumura K.,
RA   Goto K., Ishihara M., Nakamura S., Yonemoto J., Kikuti Y.Y., Shiina T.,
RA   Chen L., Ando A., Ikemura T., Inoko H.;
RT   "Nucleotide sequence analysis of the HLA class I region spanning the 237-kb
RT   segment around the HLA-B and -C genes.";
RL   Genomics 42:55-66(1997).
RN   [2] {ECO:0000313|Ensembl:ENSP00000414063.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [3] {ECO:0000313|EMBL:AAH33293.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Skin {ECO:0000313|EMBL:AAH33293.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4] {ECO:0000313|EMBL:BAN59792.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23714642; DOI=10.1186/1471-2164-14-355;
RA   Hosomichi K., Jinam T.A., Mitsunaga S., Nakaoka H., Inoue I.;
RT   "Phase-defined complete sequencing of the HLA genes by next-generation
RT   sequencing.";
RL   BMC Genomics 14:355-355(2013).
RN   [5] {ECO:0000313|EMBL:CCG58319.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=24033148; DOI=10.1111/tan.12192;
RA   Cisneros E., Martinez-Pomar N., Vilches M., Martin P., de Pablo R.,
RA   Nunez Del Prado N., Nieto A., Matamoros N., Moraru M., Vilches C.;
RT   "Advancing allele group-specific amplification of the complete HLA-C
RT   gene--isolation of novel alleles from three allele groups (C*04, C*07 and
RT   C*08).";
RL   Tissue Antigens 82:280-285(2013).
RN   [6] {ECO:0000313|EMBL:ANZ73061.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Gowda M., Ambardar S., Dighe N., Manjunath A., Shankaralingu C.,
RA   Hirannaiah P., Harting J., Ranade S., Jagannathan L., Krishna S.;
RT   "Comparative Analyses of Low, Medium and High-Resolution HLA Typing
RT   Technologies for Human Populations.";
RL   J Clin Cell Immunol 7 (2) 0:399-399(2016).
RN   [7] {ECO:0000313|EMBL:CDQ51644.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=28547825; DOI=10.1111/tan.13057;
RA   Albrecht V., Zweiniger C., Surendranath V., Lang K., Schofl G., Dahl A.,
RA   Winkler S., Lange V., Bohme I., Schmidt A.H.;
RT   "Dual redundant sequencing strategy: Full-length gene characterisation of
RT   1056 novel and confirmatory HLA alleles.";
RL   HLA 90:79-87(2017).
RN   [8] {ECO:0000313|EMBL:ASE99686.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=29327506; DOI=.1111/tan.13210;
RA   Hurley C.K., Hou L., Lazaro A., Gerfen J., Enriquez E., Galarza P.,
RA   Rodriguez Cardozo M.B., Halagan M., Maiers M., Behm D., Ng J.;
RT   "Next generation sequencing characterizes the extent of HLA diversity in an
RT   Argentinian registry population.";
RL   HLA 91:175-186(2018).
RN   [9] {ECO:0000313|Ensembl:ENSP00000414063.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2022) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC       {ECO:0000256|RuleBase:RU004439}.
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DR   EMBL; AL662833; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC033293; AAH33293.1; -; mRNA.
DR   EMBL; KX649950; ANZ73061.1; -; Genomic_DNA.
DR   EMBL; KY626050; ASE99686.1; -; Genomic_DNA.
DR   EMBL; D83957; BAA22206.1; -; Genomic_DNA.
DR   EMBL; AB774946; BAN59792.1; -; Genomic_DNA.
DR   EMBL; HE793165; CCG58319.1; -; Genomic_DNA.
DR   EMBL; LK021963; CDQ51644.1; -; Genomic_DNA.
DR   EMBL; LN600112; CEF48102.2; -; Genomic_DNA.
DR   RefSeq; NP_001229971.1; NM_001243042.1.
DR   SMR; O19617; -.
DR   SwissPalm; O19617; -.
DR   MassIVE; O19617; -.
DR   ProteomicsDB; 48758; -.
DR   DNASU; 3107; -.
DR   Ensembl; ENST00000424832.6; ENSP00000414063.2; ENSG00000233841.11.
DR   GeneID; 3107; -.
DR   UCSC; uc011fcf.3; human.
DR   CTD; 3107; -.
DR   HGNC; HGNC:4933; HLA-C.
DR   OrthoDB; 3840485at2759; -.
DR   BioGRID-ORCS; 3107; 296 hits in 1058 CRISPR screens.
DR   ChiTaRS; HLA-C; human.
DR   GenomeRNAi; 3107; -.
DR   Proteomes; UP000005640; Unplaced.
DR   GO; GO:0009986; C:cell surface; IEA:UniProt.
DR   GO; GO:0031901; C:early endosome membrane; IEA:UniProt.
DR   GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProt.
DR   GO; GO:0098553; C:lumenal side of endoplasmic reticulum membrane; IEA:UniProt.
DR   GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProt.
DR   GO; GO:0055038; C:recycling endosome membrane; IEA:UniProt.
DR   GO; GO:0019882; P:antigen processing and presentation; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   CDD; cd07698; IgC1_MHC_I_alpha3; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011161; MHC_I-like_Ag-recog.
DR   InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR001039; MHC_I_a_a1/a2.
DR   InterPro; IPR010579; MHC_I_a_C.
DR   PANTHER; PTHR16675:SF252; HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN; 1.
DR   PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   SMART; SM00407; IGc1; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0007829|EPD:O19617,
KW   ECO:0007829|MaxQB:O19617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..366
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015096743"
FT   TRANSMEM        308..331
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          209..297
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
SQ   SEQUENCE   366 AA;  40711 MW;  0B9518E6AA77A609 CRC64;
     MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG YVDDTQFVRF
     DSDAASPRGE PRAPWVEQEG PEYWDRETQN YKRQAQADRV SLRNLRGYYN QSEDGSHTLQ
     RMYGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK LEAARAAEQL
     RAYLEGTCVE WLRRYLENGK ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL QEPLTLSWEP
     SSQPTIPIMG IVAGLAVLVV LAVLGAVVTA MMCRRKSSGG KGGSCSQAAC SNSAQGSDES
     LITCKA
//