O19617 (O19617_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
HLA class I antigen EMBL BAA22206.1

Submitted name:
HLA-C protein EMBL BAB63310.1
Submitted name:
MHC class I antigen EMBL ACV91118.1
Submitted name:
Major histocompatibility complex, class I, C EMBL AAH33293.1

Gene names

Name:	HLA-C EMBL BAA22206.1
Synonyms:	HLA-Cw EMBL ACV91118.1

Organism

Homo sapiens (Human) EMBL BAA22206.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in the presentation of foreign antigens to the immune system By similarity. SAAS SAAS010579
Sequence similarities	Belongs to the MHC class I family. RuleBase RU004439 Contains 1 Ig-like C1-type (immunoglobulin-like) domain. SAAS SAAS010579

Ontologies

Keywords
Biological process	Immunity
Cellular component	MHC I SAAS SAAS010579 Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS010579
Gene Ontology (GO)
Biological_process	antigen processing and presentation of peptide antigen via MHC class I Inferred from electronic annotation. Source: UniProtKB-KW immune response Inferred from electronic annotation. Source: InterPro
Cellular_component	MHC class I protein complex Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O19617 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 0B9518E6AA77A609	FASTA	366	40,711
	10 20 30 40 50 60 MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG YVDDTQFVRF 70 80 90 100 110 120 DSDAASPRGE PRAPWVEQEG PEYWDRETQN YKRQAQADRV SLRNLRGYYN QSEDGSHTLQ 130 140 150 160 170 180 RMYGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK LEAARAAEQL 190 200 210 220 230 240 RAYLEGTCVE WLRRYLENGK ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT 250 260 270 280 290 300 WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL QEPLTLSWEP 310 320 330 340 350 360 SSQPTIPIMG IVAGLAVLVV LAVLGAVVTA MMCRRKSSGG KGGSCSQAAC SNSAQGSDES LITCKA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence analysis of the HLA class I region spanning the 237-kb segment around the HLA-B and -C genes." Mizuki N., Ando H., Kimura M., Ohno S., Miyata S., Yamazaki M., Tashiro H., Watanabe K., Ono A., Taguchi S., Sugawara C., Fukuzumi Y., Okumura K., Goto K., Ishihara M., Nakamura S., Yonemoto J., Kikuti Y.Y. , Shiina T., Chen L., Ando A., Ikemura T., Inoko H. Genomics 42:55-66(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	Hirakawa M., Yamaguchi H., Imai K., Shimada J. Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin EMBL AAH33293.1.
[4]	"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region." Shiina S., Tamiya G., Oka A., Inoko H. Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[5]	"Characterization and polymorphism analyses of HLA-C genomic full length in Chinese Han population." Xu Y., Deng Z., Wang D. Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[6]	"Novel HLA-C alleles." Cisneros E., de Pablo R., Moraru M., Vilches C. Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[7]	"Confirmation of rare HLA class I alleles." Witter K. Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC033293 mRNA. Translation: AAH33293.1. GQ472838 Genomic DNA. Translation: ACV91118.1. GQ472839 Genomic DNA. Translation: ACV91119.1. D83957 Genomic DNA. Translation: BAA22206.1. BA000025 Genomic DNA. Translation: BAB63310.1. HE793165 Genomic DNA. Translation: CCG58319.1. HF565303 Genomic DNA. Translation: CCP37718.1.
IPI	IPI00657976.
RefSeq	NP_001229971.1. NM_001243042.1.
UniGene	Hs.654404. Hs.656020.
3D structure databases
HSSP	HSSP built from PDB template 1M05 based on UniProtKB Q9MY78.
SMR	O19617. Positions 26-298.
ModBase	Search...
Protocols and materials databases
DNASU	3107.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3107.
KEGG	hsa:3107.
UCSC	uc011fcd.2. human.
Organism-specific databases
CTD	3107.
H-InvDB	HIX0151763.
Phylogenomic databases
HOVERGEN	HBG016709.
KO	K06751.
Family and domain databases
Gene3D	2.60.40.10. 1 hit. 3.30.500.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003597. Ig_C1-set. IPR011161. MHC_I-like_Ag-recog. IPR011162. MHC_I/II-like_Ag-recog. IPR001039. MHC_I_a_a1/a2. IPR010579. MHC_I_a_C. [Graphical view]
Pfam	PF07654. C1-set. 1 hit. PF00129. MHC_I. 1 hit. PF06623. MHC_I_C. 1 hit. [Graphical view]
PRINTS	PR01638. MHCCLASSI.
SMART	SM00407. IGc1. 1 hit. [Graphical view]
SUPFAM	SSF54452. MHC_I/II-like_Ag-recog. 1 hit.
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HLA-C. human.
GenomeRNAi	3107.
NextBio	12327.

Entry information

Entry name

O19617_HUMAN

Accession

Primary (citable) accession number: O19617

Entry history

Integrated into UniProtKB/TrEMBL:	January 1, 1998
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 113 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.