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O19617 (O19617_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names

HLA-C protein EMBL BAB63310.1

MHC class I antigen EMBL ACV91118.1

Major histocompatibility complex, class I, C EMBL AAH33293.1
Gene names
Name:HLA-C EMBL BAA22206.1
Synonyms:HLA-Cw EMBL ACV91118.1
OrganismHomo sapiens (Human) EMBL BAA22206.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the presentation of foreign antigens to the immune system By similarity. SAAS SAAS027648

Sequence similarities

Belongs to the MHC class I family. RuleBase RU004439

Contains Ig-like C1-type (immunoglobulin-like) domain. SAAS SAAS027648

Sequences

Sequence LengthMass (Da)Tools
O19617 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 0B9518E6AA77A609

FASTA36640,711
        10         20         30         40         50         60 
MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG YVDDTQFVRF 

        70         80         90        100        110        120 
DSDAASPRGE PRAPWVEQEG PEYWDRETQN YKRQAQADRV SLRNLRGYYN QSEDGSHTLQ 

       130        140        150        160        170        180 
RMYGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK LEAARAAEQL 

       190        200        210        220        230        240 
RAYLEGTCVE WLRRYLENGK ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT 

       250        260        270        280        290        300 
WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL QEPLTLSWEP 

       310        320        330        340        350        360 
SSQPTIPIMG IVAGLAVLVV LAVLGAVVTA MMCRRKSSGG KGGSCSQAAC SNSAQGSDES 


LITCKA 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence analysis of the HLA class I region spanning the 237-kb segment around the HLA-B and -C genes."
Mizuki N., Ando H., Kimura M., Ohno S., Miyata S., Yamazaki M., Tashiro H., Watanabe K., Ono A., Taguchi S., Sugawara C., Fukuzumi Y., Okumura K., Goto K., Ishihara M., Nakamura S., Yonemoto J., Kikuti Y.Y. expand/collapse author list , Shiina T., Chen L., Ando A., Ikemura T., Inoko H.
Genomics 42:55-66(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]Hirakawa M., Yamaguchi H., Imai K., Shimada J.
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin EMBL AAH33293.1.
[4]"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
Shiina S., Tamiya G., Oka A., Inoko H.
Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[5]"Characterization and polymorphism analyses of HLA-C genomic full length in Chinese Han population."
Xu Y., Deng Z., Wang D.
Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[6]"Confirmation of rare HLA class I alleles."
Witter K.
Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[7]"Phase-defined complete sequencing of the HLA genes by next-generation sequencing."
Hosomichi K., Jinam T.A., Mitsunaga S., Nakaoka H., Inoue I.
BMC Genomics 14:355-355(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[8]"Advancing allele group-specific amplification of the complete HLA-C gene--isolation of novel alleles from three allele groups (C*04, C*07 and C*08)."
Cisneros E., Martinez-Pomar N., Vilches M., Martin P., de Pablo R., Nunez Del Prado N., Nieto A., Matamoros N., Moraru M., Vilches C.
Tissue Antigens 82:280-285(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[9]"Confirmatory sequencing of HLA-C*07:01:01:01."
McWhinnie A.J., Robinson J.
Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Lymphoblastoid cell line EMBL CDK41184.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC033293 mRNA. Translation: AAH33293.1.
GQ472838 Genomic DNA. Translation: ACV91118.1.
GQ472839 Genomic DNA. Translation: ACV91119.1.
D83957 Genomic DNA. Translation: BAA22206.1.
BA000025 Genomic DNA. Translation: BAB63310.1.
AB774946 Genomic DNA. Translation: BAN59792.1.
HE793165 Genomic DNA. Translation: CCG58319.1.
HF565303 Genomic DNA. Translation: CCP37718.1.
HG794375 Genomic DNA. Translation: CDK41184.1.
HG794378 Genomic DNA. Translation: CDK41187.1.
RefSeqNP_001229971.1. NM_001243042.1.
UniGeneHs.656020.
Hs.743218.
Hs.77961.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

DNASU3107.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3107.
KEGGhsa:3107.
UCSCuc011fcd.2. human.

Organism-specific databases

CTD3107.
H-InvDBHIX0151763.

Phylogenomic databases

HOVERGENHBG016709.
KOK06751.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSPR01638. MHCCLASSI.
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHLA-C. human.
GenomeRNAi3107.
NextBio12327.

Entry information

Entry nameO19617_HUMAN
AccessionPrimary (citable) accession number: O19617
Entry history
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.