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O19617

- O19617_HUMAN

UniProt

O19617 - O19617_HUMAN

Protein
Submitted name:

HLA class I antigen

Gene

HLA-C

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Involved in the presentation of foreign antigens to the immune system.SAAS annotation

    GO - Molecular functioni

    1. peptide antigen binding Source: InterPro

    GO - Biological processi

    1. antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
    2. immune response Source: InterPro
    3. positive regulation of T cell mediated cytotoxicity Source: InterPro

    Keywords - Biological processi

    Immunity

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    HLA class I antigenImported
    Submitted name:
    HLA-C proteinImported
    Submitted name:
    MHC class I antigenImported
    Submitted name:
    Major histocompatibility complex, class I, CImported
    Gene namesi
    Name:HLA-CImported
    Synonyms:HLA-CwImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. MHC class I protein complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, MHC ISAAS annotation

    Structurei

    3D structure databases

    SMRiO19617. Positions 26-298.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MHC class I family.UniRule annotation
    Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG016709.
    KOiK06751.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    IPR010579. MHC_I_a_C.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    PF06623. MHC_I_C. 1 hit.
    [Graphical view]
    PRINTSiPR01638. MHCCLASSI.
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O19617-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG    50
    YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQN YKRQAQADRV 100
    SLRNLRGYYN QSEDGSHTLQ RMYGCDLGPD GRLLRGYDQS AYDGKDYIAL 150
    NEDLRSWTAA DTAAQITQRK LEAARAAEQL RAYLEGTCVE WLRRYLENGK 200
    ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ 250
    DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL QEPLTLSWEP 300
    SSQPTIPIMG IVAGLAVLVV LAVLGAVVTA MMCRRKSSGG KGGSCSQAAC 350
    SNSAQGSDES LITCKA 366
    Length:366
    Mass (Da):40,711
    Last modified:January 1, 1998 - v1
    Checksum:i0B9518E6AA77A609
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC033293 mRNA. Translation: AAH33293.1.
    GQ472838 Genomic DNA. Translation: ACV91118.1.
    GQ472839 Genomic DNA. Translation: ACV91119.1.
    D83957 Genomic DNA. Translation: BAA22206.1.
    BA000025 Genomic DNA. Translation: BAB63310.1.
    AB774946 Genomic DNA. Translation: BAN59792.1.
    HE793165 Genomic DNA. Translation: CCG58319.1.
    HF565303 Genomic DNA. Translation: CCP37718.1.
    HG794375 Genomic DNA. Translation: CDK41184.1.
    HG794378 Genomic DNA. Translation: CDK41187.1.
    LK021963 Genomic DNA. Translation: CDQ51644.1.
    RefSeqiNP_001229971.1. NM_001243042.1.
    UniGeneiHs.656020.
    Hs.743218.
    Hs.77961.

    Genome annotation databases

    GeneIDi3107.
    KEGGihsa:3107.
    UCSCiuc011fcd.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC033293 mRNA. Translation: AAH33293.1 .
    GQ472838 Genomic DNA. Translation: ACV91118.1 .
    GQ472839 Genomic DNA. Translation: ACV91119.1 .
    D83957 Genomic DNA. Translation: BAA22206.1 .
    BA000025 Genomic DNA. Translation: BAB63310.1 .
    AB774946 Genomic DNA. Translation: BAN59792.1 .
    HE793165 Genomic DNA. Translation: CCG58319.1 .
    HF565303 Genomic DNA. Translation: CCP37718.1 .
    HG794375 Genomic DNA. Translation: CDK41184.1 .
    HG794378 Genomic DNA. Translation: CDK41187.1 .
    LK021963 Genomic DNA. Translation: CDQ51644.1 .
    RefSeqi NP_001229971.1. NM_001243042.1.
    UniGenei Hs.656020.
    Hs.743218.
    Hs.77961.

    3D structure databases

    SMRi O19617. Positions 26-298.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 3107.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3107.
    KEGGi hsa:3107.
    UCSCi uc011fcd.2. human.

    Organism-specific databases

    CTDi 3107.
    H-InvDB HIX0151763.

    Phylogenomic databases

    HOVERGENi HBG016709.
    KOi K06751.

    Miscellaneous databases

    ChiTaRSi HLA-C. human.
    GenomeRNAii 3107.
    NextBioi 12327.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    IPR010579. MHC_I_a_C.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    PF06623. MHC_I_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01638. MHCCLASSI.
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
    2. Hirakawa M., Yamaguchi H., Imai K., Shimada J.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: SkinImported.
    4. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
      Shiina S., Tamiya G., Oka A., Inoko H.
      Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    5. "Characterization and polymorphism analyses of HLA-C genomic full length in Chinese Han population."
      Xu Y., Deng Z., Wang D.
      Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    6. "Confirmation of rare HLA class I alleles."
      Witter K.
      Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    7. "Phase-defined complete sequencing of the HLA genes by next-generation sequencing."
      Hosomichi K., Jinam T.A., Mitsunaga S., Nakaoka H., Inoue I.
      BMC Genomics 14:355-355(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    8. "Advancing allele group-specific amplification of the complete HLA-C gene--isolation of novel alleles from three allele groups (C*04, C*07 and C*08)."
      Cisneros E., Martinez-Pomar N., Vilches M., Martin P., de Pablo R., Nunez Del Prado N., Nieto A., Matamoros N., Moraru M., Vilches C.
      Tissue Antigens 82:280-285(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    9. "Confirmatory sequencing of HLA-C*07:01:01:01."
      McWhinnie A.J., Robinson J.
      Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Lymphoblastoid cell lineImported.
    10. "Characterisation and Confirmation of new HLA-Alleles found by DKMS Life Science Lab."
      Albrecht V., Boehme I., Schmidt A.H.
      Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiO19617_HUMAN
    AccessioniPrimary (citable) accession number: O19617
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 1, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.