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Protein
Submitted name:

HLA class I antigen

Gene

HLA-C

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Submitted name:
HLA class I antigenImported
Submitted name:
HLA class I histocompatibility antigen, Cw-6 alpha chainImported
Submitted name:
HLA-C proteinImported
Submitted name:
MHC class I antigenImported
Submitted name:
Major histocompatibility complex, class I, CImported
Gene namesi
Name:HLA-CImported
Synonyms:HLA-CwImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4933 HLA-C

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei308 – 331HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane, MHC ISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_501458565825 – 366Sequence analysisAdd BLAST342

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 297Ig-likeInterPro annotationAdd BLAST89

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410II5V Eukaryota
ENOG4111K8F LUCA
HOVERGENiHBG016709

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

O19617-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG
60 70 80 90 100
YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQN YKRQAQADRV
110 120 130 140 150
SLRNLRGYYN QSEDGSHTLQ RMYGCDLGPD GRLLRGYDQS AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DTAAQITQRK LEAARAAEQL RAYLEGTCVE WLRRYLENGK
210 220 230 240 250
ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL QEPLTLSWEP
310 320 330 340 350
SSQPTIPIMG IVAGLAVLVV LAVLGAVVTA MMCRRKSSGG KGGSCSQAAC
360
SNSAQGSDES LITCKA
Length:366
Mass (Da):40,711
Last modified:January 1, 1998 - v1
Checksum:i0B9518E6AA77A609
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662833 Genomic DNA No translation available.
BC033293 mRNA Translation: AAH33293.1
GQ472838 Genomic DNA Translation: ACV91118.1
GQ472839 Genomic DNA Translation: ACV91119.1
KU528607 Genomic DNA Translation: ALZ40822.1
KU319188 Genomic DNA Translation: ANG08604.1
KU319189 Genomic DNA Translation: ANG08605.1
KY622045 Genomic DNA Translation: ASE99681.1
KY626050 Genomic DNA Translation: ASE99686.1
KY419402 Genomic DNA Translation: ASU50293.1
KY419403 Genomic DNA Translation: ASU50294.1
KY419404 Genomic DNA Translation: ASU50295.1
KY419405 Genomic DNA Translation: ASU50296.1
MF981006 Genomic DNA Translation: ATV81380.1
KY499646 Genomic DNA Translation: AUN50126.1
MG747476 Genomic DNA Translation: AUZ98368.1
MG779942 Genomic DNA Translation: AVC68922.1
D83957 Genomic DNA Translation: BAA22206.1
BA000025 Genomic DNA Translation: BAB63310.1
AB774946 Genomic DNA Translation: BAN59792.1
HE793165 Genomic DNA Translation: CCG58319.1
HF565303 Genomic DNA Translation: CCP37718.1
HG794375 Genomic DNA Translation: CDK41184.1
HG794378 Genomic DNA Translation: CDK41187.1
LK021963 Genomic DNA Translation: CDQ51644.1
LN600112 Genomic DNA Translation: CEF48102.2
LN624510 Genomic DNA Translation: CEH11580.1
LN811470 Genomic DNA Translation: CEP25297.1
LN832568 Genomic DNA Translation: CQR91446.1
LN877368 Genomic DNA Translation: CUA55111.1
LN912841 Genomic DNA Translation: CUU97168.1
LN912851 Genomic DNA Translation: CUU97178.1
LN912882 Genomic DNA Translation: CUU97209.1
LN912964 Genomic DNA Translation: CUU97291.1
LN912965 Genomic DNA Translation: CUU97292.1
LN912966 Genomic DNA Translation: CUU97293.1
LN912967 Genomic DNA Translation: CUU97294.1
LN912968 Genomic DNA Translation: CUU97295.1
LT575524 Genomic DNA Translation: SBL08196.1
LT599302 Genomic DNA Translation: SBW38523.1
LT599310 Genomic DNA Translation: SBW38531.1
LT599317 Genomic DNA Translation: SBW38538.1
LT599328 Genomic DNA Translation: SBW38549.1
LT618799 Genomic DNA Translation: SCQ83615.1
LT627695 Genomic DNA Translation: SFV42124.1
LT898183 Genomic DNA Translation: SNQ25993.1
LT964794 Genomic DNA Translation: SOT92898.1
LT964813 Genomic DNA Translation: SOT92917.1
LT964820 Genomic DNA Translation: SOT92924.1
LT964841 Genomic DNA Translation: SOT92945.1
LT964849 Genomic DNA Translation: SOT92953.1
LT964853 Genomic DNA Translation: SOT92957.1
LT966143 Genomic DNA Translation: SOU90297.1
LT966190 Genomic DNA Translation: SOU90344.1
LT966196 Genomic DNA Translation: SOU90350.1
LT966226 Genomic DNA Translation: SOU90380.1
LT966290 Genomic DNA Translation: SOU90444.1
LT966291 Genomic DNA Translation: SOU90445.1
LT966393 Genomic DNA Translation: SOU94030.1
LT990031 Genomic DNA Translation: SPI58569.1
RefSeqiNP_001229971.1, NM_001243042.1
UniGeneiHs.656020
Hs.743218

Genome annotation databases

EnsembliENST00000424832; ENSP00000414063; ENSG00000233841
GeneIDi3107
UCSCiuc011fcf.3 human

Similar proteinsi

Entry informationi

Entry nameiO19617_HUMAN
AccessioniPrimary (citable) accession number: O19617
Secondary accession number(s): A0A090KMD8
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health