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Protein
Submitted name:

HLA class I antigen

Gene

HLA-C

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Submitted name:
HLA class I antigenImported
Submitted name:
HLA class I histocompatibility antigen, Cw-6 alpha chainImported
Submitted name:
HLA-C proteinImported
Submitted name:
MHC class I antigenImported
Submitted name:
Major histocompatibility complex, class I, CImported
Gene namesi
Name:HLA-CImported
Synonyms:HLA-CwImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4933. HLA-C.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei308 – 331HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC ISAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000233841.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500877856825 – 366Sequence analysisAdd BLAST342

Expressioni

Gene expression databases

BgeeiENSG00000233841.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000365402.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 297Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST89

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
HOVERGENiHBG016709.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O19617-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG
60 70 80 90 100
YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQN YKRQAQADRV
110 120 130 140 150
SLRNLRGYYN QSEDGSHTLQ RMYGCDLGPD GRLLRGYDQS AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DTAAQITQRK LEAARAAEQL RAYLEGTCVE WLRRYLENGK
210 220 230 240 250
ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL QEPLTLSWEP
310 320 330 340 350
SSQPTIPIMG IVAGLAVLVV LAVLGAVVTA MMCRRKSSGG KGGSCSQAAC
360
SNSAQGSDES LITCKA
Length:366
Mass (Da):40,711
Last modified:January 1, 1998 - v1
Checksum:i0B9518E6AA77A609
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662833 Genomic DNA. No translation available.
BC033293 mRNA. Translation: AAH33293.1.
GQ472838 Genomic DNA. Translation: ACV91118.1.
GQ472839 Genomic DNA. Translation: ACV91119.1.
KU528607 Genomic DNA. Translation: ALZ40822.1.
KU319188 Genomic DNA. Translation: ANG08604.1.
KU319189 Genomic DNA. Translation: ANG08605.1.
D83957 Genomic DNA. Translation: BAA22206.1.
BA000025 Genomic DNA. Translation: BAB63310.1.
AB774946 Genomic DNA. Translation: BAN59792.1.
HE793165 Genomic DNA. Translation: CCG58319.1.
HF565303 Genomic DNA. Translation: CCP37718.1.
HG794375 Genomic DNA. Translation: CDK41184.1.
HG794378 Genomic DNA. Translation: CDK41187.1.
LK021963 Genomic DNA. Translation: CDQ51644.1.
LN624510 Genomic DNA. Translation: CEH11580.1.
LN811470 Genomic DNA. Translation: CEP25297.1.
LN832568 Genomic DNA. Translation: CQR91446.1.
LN877368 Genomic DNA. Translation: CUA55111.1.
LN912841 Genomic DNA. Translation: CUU97168.1.
LN912851 Genomic DNA. Translation: CUU97178.1.
LN912882 Genomic DNA. Translation: CUU97209.1.
LN912964 Genomic DNA. Translation: CUU97291.1.
LN912965 Genomic DNA. Translation: CUU97292.1.
LN912966 Genomic DNA. Translation: CUU97293.1.
LN912967 Genomic DNA. Translation: CUU97294.1.
LN912968 Genomic DNA. Translation: CUU97295.1.
LT599302 Genomic DNA. Translation: SBW38523.1.
LT599310 Genomic DNA. Translation: SBW38531.1.
LT599317 Genomic DNA. Translation: SBW38538.1.
LT599328 Genomic DNA. Translation: SBW38549.1.
RefSeqiNP_001229971.1. NM_001243042.1.
UniGeneiHs.656020.
Hs.743218.

Genome annotation databases

EnsembliENST00000424832; ENSP00000414063; ENSG00000233841.
GeneIDi3107.
UCSCiuc011fcf.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662833 Genomic DNA. No translation available.
BC033293 mRNA. Translation: AAH33293.1.
GQ472838 Genomic DNA. Translation: ACV91118.1.
GQ472839 Genomic DNA. Translation: ACV91119.1.
KU528607 Genomic DNA. Translation: ALZ40822.1.
KU319188 Genomic DNA. Translation: ANG08604.1.
KU319189 Genomic DNA. Translation: ANG08605.1.
D83957 Genomic DNA. Translation: BAA22206.1.
BA000025 Genomic DNA. Translation: BAB63310.1.
AB774946 Genomic DNA. Translation: BAN59792.1.
HE793165 Genomic DNA. Translation: CCG58319.1.
HF565303 Genomic DNA. Translation: CCP37718.1.
HG794375 Genomic DNA. Translation: CDK41184.1.
HG794378 Genomic DNA. Translation: CDK41187.1.
LK021963 Genomic DNA. Translation: CDQ51644.1.
LN624510 Genomic DNA. Translation: CEH11580.1.
LN811470 Genomic DNA. Translation: CEP25297.1.
LN832568 Genomic DNA. Translation: CQR91446.1.
LN877368 Genomic DNA. Translation: CUA55111.1.
LN912841 Genomic DNA. Translation: CUU97168.1.
LN912851 Genomic DNA. Translation: CUU97178.1.
LN912882 Genomic DNA. Translation: CUU97209.1.
LN912964 Genomic DNA. Translation: CUU97291.1.
LN912965 Genomic DNA. Translation: CUU97292.1.
LN912966 Genomic DNA. Translation: CUU97293.1.
LN912967 Genomic DNA. Translation: CUU97294.1.
LN912968 Genomic DNA. Translation: CUU97295.1.
LT599302 Genomic DNA. Translation: SBW38523.1.
LT599310 Genomic DNA. Translation: SBW38531.1.
LT599317 Genomic DNA. Translation: SBW38538.1.
LT599328 Genomic DNA. Translation: SBW38549.1.
RefSeqiNP_001229971.1. NM_001243042.1.
UniGeneiHs.656020.
Hs.743218.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000365402.

Protocols and materials databases

DNASUi3107.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000424832; ENSP00000414063; ENSG00000233841.
GeneIDi3107.
UCSCiuc011fcf.3. human.

Organism-specific databases

CTDi3107.
H-InvDBHIX0151763.
HGNCiHGNC:4933. HLA-C.
OpenTargetsiENSG00000233841.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
HOVERGENiHBG016709.

Miscellaneous databases

ChiTaRSiHLA-C. human.
GenomeRNAii3107.

Gene expression databases

BgeeiENSG00000233841.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO19617_HUMAN
AccessioniPrimary (citable) accession number: O19617
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.