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O19470

- O19470_MOUSE

UniProt

O19470 - O19470_MOUSE

Protein
Submitted name:

MHC class II H2-I-A-beta gene (k haplotype), 3' end

Gene

H2-Ab1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. peptide antigen binding Source: MGI
    2. protein binding Source: MGI

    GO - Biological processi

    1. antigen processing and presentation Source: MGI
    2. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: MGI
    3. antigen processing and presentation of peptide antigen Source: MGI
    4. immune response Source: MGI

    Keywords - Biological processi

    Immunity

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    MHC class II H2-I-A-beta gene (k haplotype), 3' endImported
    Gene namesi
    Name:H2-Ab1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:103070. H2-Ab1.

    Subcellular locationi

    GO - Cellular componenti

    1. early endosome Source: MGI
    2. external side of plasma membrane Source: MGI
    3. Golgi apparatus Source: MGI
    4. integral component of membrane Source: MGI
    5. intracellular Source: MGI
    6. MHC class II protein complex Source: MGI
    7. multivesicular body Source: MGI
    8. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane, MHC IIUniRule annotationSAAS annotation

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriO19470.

    Structurei

    3D structure databases

    ProteinModelPortaliO19470.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG012730.
    InParanoidiO19470.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR000353. MHC_II_b_N.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00969. MHC_II_beta. 1 hit.
    [Graphical view]
    ProDomiPD000328. MHC_II_b_N. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00407. IGc1. 1 hit.
    SM00921. MHC_II_beta. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    O19470-1 [UniParc]FASTAAdd to Basket

    « Hide

    HFVHQFQPFC YFTNGTQRIR LVIRYIYNRE EYVRFDSDVG EYRAVTELGR    50
    PDAEYWNKQY LERTRAELDT VCRHNYEKTE TPTSLRRLEQ PSVVISLSRT 100
    EALNHHNTLV CSVTDFYPAK IKVRWFRNGQ EETVGVSSTQ LIRNGDWTFQ 150
    VLVMLEMTPR RGEVYTCHVE HPSLKSPITV EWRAQSESAR SKMLSGIGGC 200
    VLGVIFLGLG LFIRHRSQKG PRGPPPAGLL Q 231
    Length:231
    Mass (Da):26,748
    Last modified:January 1, 1998 - v1
    Checksum:i26769976A04076E7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21932 mRNA. Translation: AAA39637.1.
    UniGeneiMm.254067.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21932 mRNA. Translation: AAA39637.1 .
    UniGenei Mm.254067.

    3D structure databases

    ProteinModelPortali O19470.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:103070. H2-Ab1.

    Phylogenomic databases

    HOVERGENi HBG012730.
    InParanoidi O19470.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    Genevestigatori O19470.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR000353. MHC_II_b_N.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00969. MHC_II_beta. 1 hit.
    [Graphical view ]
    ProDomi PD000328. MHC_II_b_N. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00407. IGc1. 1 hit.
    SM00921. MHC_II_beta. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Signaling to a B-cell clone by Ek, but not Ak, does not reflect alteration of Ak genes."
      Bishop G.A., McMillan M.S., Haughton G., Frelinger J.A.
      Immunogenetics 28:184-192(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiO19470_MOUSE
    AccessioniPrimary (citable) accession number: O19470
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 1, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)