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O19470

- O19470_MOUSE

UniProt

O19470 - O19470_MOUSE

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Protein
Submitted name:

MHC class II H2-I-A-beta gene (k haplotype), 3' end

Gene

H2-Ab1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. peptide antigen binding Source: MGI

GO - Biological processi

  1. antigen processing and presentation Source: MGI
  2. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: MGI
  3. antigen processing and presentation of peptide antigen Source: MGI
  4. immune response Source: MGI
Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class II H2-I-A-beta gene (k haplotype), 3' endImported
Gene namesi
Name:H2-Ab1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:103070. H2-Ab1.

Subcellular locationi

GO - Cellular componenti

  1. early endosome Source: MGI
  2. external side of plasma membrane Source: MGI
  3. Golgi apparatus Source: MGI
  4. integral component of membrane Source: MGI
  5. intracellular Source: MGI
  6. MHC class II protein complex Source: MGI
  7. multivesicular body Source: MGI
  8. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC IIUniRule annotationSAAS annotation

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

GenevestigatoriO19470.

Structurei

3D structure databases

ProteinModelPortaliO19470.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG012730.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

O19470-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
HFVHQFQPFC YFTNGTQRIR LVIRYIYNRE EYVRFDSDVG EYRAVTELGR
60 70 80 90 100
PDAEYWNKQY LERTRAELDT VCRHNYEKTE TPTSLRRLEQ PSVVISLSRT
110 120 130 140 150
EALNHHNTLV CSVTDFYPAK IKVRWFRNGQ EETVGVSSTQ LIRNGDWTFQ
160 170 180 190 200
VLVMLEMTPR RGEVYTCHVE HPSLKSPITV EWRAQSESAR SKMLSGIGGC
210 220 230
VLGVIFLGLG LFIRHRSQKG PRGPPPAGLL Q
Length:231
Mass (Da):26,748
Last modified:January 1, 1998 - v1
Checksum:i26769976A04076E7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21932 mRNA. Translation: AAA39637.1.
UniGeneiMm.254067.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21932 mRNA. Translation: AAA39637.1 .
UniGenei Mm.254067.

3D structure databases

ProteinModelPortali O19470.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:103070. H2-Ab1.

Phylogenomic databases

HOVERGENi HBG012730.

Miscellaneous databases

SOURCEi Search...

Gene expression databases

Genevestigatori O19470.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view ]
ProDomi PD000328. MHC_II_b_N. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Signaling to a B-cell clone by Ek, but not Ak, does not reflect alteration of Ak genes."
    Bishop G.A., McMillan M.S., Haughton G., Frelinger J.A.
    Immunogenetics 28:184-192(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO19470_MOUSE
AccessioniPrimary (citable) accession number: O19470
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: November 26, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)