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Protein
Submitted name:

MHC class I antigen

Gene

PD1

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class I antigenImported
Gene namesi
Name:PD1Imported
Synonyms:SLA-1Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei304 – 32724HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC ISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 361340Sequence analysisPRO_5006739084Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi122 ↔ 185Combined sources
Disulfide bondi224 ↔ 280Combined sources

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000001298.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3QQ3X-ray2.59A/D22-296[»]
3QQ4X-ray2.10A22-296[»]
SMRiO19244. Positions 22-296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini206 – 29287Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotationSAAS annotation
Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
HOVERGENiHBG016709.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O19244-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPGALFLLL SGTLALTGTQ AGPHSLSYFY TAVSRPDRGD SRFIAVGYVD
60 70 80 90 100
DTQFVRFDNY APNPRMEPRV PWIQQEGQEY WDRETRNVKE TAQTYGVGLN
110 120 130 140 150
TLRGYYNQSE AGSHTLQSMY GCYLGPDGLL LHGYRQDAYD GADYIALNED
160 170 180 190 200
LRSWTAADMA AQITKRKWEA ADEAERRRSY LQGLCVESLR RYLEMGKDTL
210 220 230 240 250
QRAEPPKTHV TRHPSSDLGV TLRCWALGFY PKEISLTWQR EGQDQSQDME
260 270 280 290 300
LVETRPSGDG TFQKWAALVV PPGEEQSYTC HVQHEGLQEP LTLRWDPAQP
310 320 330 340 350
PVPIVGIIVG LVLVLVAGAM VAGVVIWRKT RSGEKGGSYT QAAGSDSDQG
360
SDVSLTKDPR V
Length:361
Mass (Da):40,214
Last modified:January 1, 1998 - v1
Checksum:i8468E02F9011BD89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014005 mRNA. Translation: AAB69340.1.
AF464002 mRNA. Translation: AAM20943.1.
AF464016 mRNA. Translation: AAM20974.1.
AY459306 mRNA. Translation: AAR22520.1.
DQ303228 mRNA. Translation: ABC17927.1.
EU170457 mRNA. Translation: ABW24123.1.
KC510995 mRNA. Translation: AHA85943.1.
KJ922760 mRNA. Translation: AIM47093.1.
UniGeneiSsc.18553.
Ssc.56487.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014005 mRNA. Translation: AAB69340.1.
AF464002 mRNA. Translation: AAM20943.1.
AF464016 mRNA. Translation: AAM20974.1.
AY459306 mRNA. Translation: AAR22520.1.
DQ303228 mRNA. Translation: ABC17927.1.
EU170457 mRNA. Translation: ABW24123.1.
KC510995 mRNA. Translation: AHA85943.1.
KJ922760 mRNA. Translation: AIM47093.1.
UniGeneiSsc.18553.
Ssc.56487.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3QQ3X-ray2.59A/D22-296[»]
3QQ4X-ray2.10A22-296[»]
SMRiO19244. Positions 22-296.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000001298.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
HOVERGENiHBG016709.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Analysis of polymorphism in porcine MHC class I genes: alterations in signals recognized by human cytotoxic lymphocytes."
    Sullivan J.A., Oettinger H.F., Sachs D.H., Edge A.S.
    J. Immunol. 159:2318-2326(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Valsecchi V., Ballabio A., Rugarli E.I.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Kim H.J., Lee J.H., Choi S.H.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. Gilbert H.J.
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  5. Zhang D.J., Liu D.
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  6. "Characterization of swine leukocyte antigen polymorphism by sequence-based and PCR-SSP methods in Meishan pigs."
    Ho C.S., Rochelle E.S., Martens G.W., Schook L.B., Smith D.M.
    Immunogenetics 58:873-882(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  7. NIH - Xenopus Gene Collection (XGC) project
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  8. "Sequence-based characterization of swine leucocyte antigen alleles in commercially available porcine cell lines."
    Ho C.S., Franzo-Romain M.H., Lee Y.J., Lee J.H., Smith D.M.
    Int. J. Immunogenet. 36:231-234(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  9. "Crystal structure of swine major histocompatibility complex class I SLA-1 0401 and identification of 2009 pandemic swine-origin influenza A H1N1 virus cytotoxic T lymphocyte epitope peptides."
    Zhang N., Qi J., Feng S., Gao F., Liu J., Pan X., Chen R., Li Q., Chen Z., Li X., Xia C., Gao G.F.
    J. Virol. 85:11709-11724(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 22-296, DISULFIDE BONDS.
  10. "Molecular characterization of SLA class I genes in Chinese Bama miniature pigs."
    Gao C.X., Jiang Q., Lin H., Guo D.C., Liu J.S., Yuan D.W., Si C.D., Han L.X., Qu L.D.
    Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  11. "Characterization of swine leukocyte antigen (SLA) polymorphism by sequence-based and PCR-SSP methods in Chinese Bama miniature pigs."
    Gao C., Jiang Q., Guo D., Liu J., Han L., Qu L.
    Dev. Comp. Immunol. 45:87-96(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  12. Lai Y.H.
    Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO19244_PIG
AccessioniPrimary (citable) accession number: O19244
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: May 11, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.