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Protein
Submitted name:

MHC class I antigen

Gene

PD1

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class I antigenImported
Gene namesi
Name:PD1Imported
Synonyms:SLA-1Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei304 – 327HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane, MHC ISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_501120859922 – 361Sequence analysisAdd BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi122 ↔ 185Combined sources
Disulfide bondi224 ↔ 280Combined sources

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QQ3X-ray2.59A/D22-296[»]
3QQ4X-ray2.10A22-296[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini206 – 292Ig-likeInterPro annotationAdd BLAST87

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
HOVERGENiHBG016709.

Family and domain databases

Gene3Di1.20.5.100. 1 hit.
2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiView protein in InterPro
IPR021157. Cyt_c1_TM_anchor_C.
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR037055. MHC_I-like_Ag-recog_sf.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
PfamiView protein in Pfam
PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
PRINTSiPR01638. MHCCLASSI.
SMARTiView protein in SMART
SM00407. IGc1. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Complete.

O19244-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPGALFLLL SGTLALTGTQ AGPHSLSYFY TAVSRPDRGD SRFIAVGYVD
60 70 80 90 100
DTQFVRFDNY APNPRMEPRV PWIQQEGQEY WDRETRNVKE TAQTYGVGLN
110 120 130 140 150
TLRGYYNQSE AGSHTLQSMY GCYLGPDGLL LHGYRQDAYD GADYIALNED
160 170 180 190 200
LRSWTAADMA AQITKRKWEA ADEAERRRSY LQGLCVESLR RYLEMGKDTL
210 220 230 240 250
QRAEPPKTHV TRHPSSDLGV TLRCWALGFY PKEISLTWQR EGQDQSQDME
260 270 280 290 300
LVETRPSGDG TFQKWAALVV PPGEEQSYTC HVQHEGLQEP LTLRWDPAQP
310 320 330 340 350
PVPIVGIIVG LVLVLVAGAM VAGVVIWRKT RSGEKGGSYT QAAGSDSDQG
360
SDVSLTKDPR V
Length:361
Mass (Da):40,214
Last modified:January 1, 1998 - v1
Checksum:i8468E02F9011BD89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014005 mRNA. Translation: AAB69340.1.
AF464002 mRNA. Translation: AAM20943.1.
AF464016 mRNA. Translation: AAM20974.1.
AY459306 mRNA. Translation: AAR22520.1.
DQ303228 mRNA. Translation: ABC17927.1.
EU170457 mRNA. Translation: ABW24123.1.
KC510995 mRNA. Translation: AHA85943.1.
KJ922760 mRNA. Translation: AIM47093.1.
KU754545 mRNA. Translation: AOP12403.1.
MF498778 mRNA. Translation: ASO67425.1.
UniGeneiSsc.18553.
Ssc.56487.
Ssc.5754.

Similar proteinsi

Entry informationi

Entry nameiO19244_PIG
AccessioniPrimary (citable) accession number: O19244
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: November 22, 2017
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources