Reviewed, UniProtKB/Swiss-Prot O19175 (KC1A_PIG)

Names and origin

Protein names

Recommended name:
    Casein kinase I isoform alpha
      Short name=CKI-alpha
    EC=2.7.11.1
Alternative name(s):
    CK1

Gene names

Name:

CSNK1A1

Organism

Sus scrofa (Pig)

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	125 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 on 'Ser-45' By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subunit structure	Monomer. Interacts with the Axin complex By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›125	›125	Casein kinase I isoform alpha		PRO_0000192824
Regions
	Domain	‹1 – ›125	›125	Protein kinase
Sites
	Active site	97	1	Proton acceptor By similarity
	Binding site	7	1	ATP By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	125	1

Sequences

	Sequence		Length	Mass (Da)
	O19175-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: EB44429E8A2FC7A5	FASTA	125	14,633
	10 20 30 40 50 60 GEEVAVKLES QKARHPQLLY ESKLYKILQG GVGIPHIRWY GQEKDYNVLV MDLLGPSLED 70 80 90 100 110 120 LFNFCSRRFT MKTVLMLADQ MISRIEYVHT KNFIHRDIKP DNFLMGIGRH CNKLFLIDFG LAKKY

References

[1]	"Evaluation and characterization of a porcine small intestine cDNA library: analysis of 839 clones." Winteroe A.K., Fredholm M., Davies W. Mamm. Genome 7:509-517(1996) [PubMed: 8672129] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Small intestine.

Cross-references

Sequence databases
EMBLGenBankDDBJ	F22872 mRNA. Translation: CAA23396.1.
3D structure databases
HSSP	HSSP built from PDB template 1CKI based on UniProtKB Q06486.
SMR	O19175. Positions 1-125.
ModBase	Search...
Phylogenomic databases
HOVERGEN	O19175.
Enzyme and pathway databases
BRENDA	2.7.11.1. 249.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00107. PROTEIN_KINASE_ATP. Partial match. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
BindingDB	O19175.

Entry information

Entry name

KC1A_PIG

Accession

Primary (citable) accession number: O19175

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	January 1, 1998
Last modified:	June 16, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)