O19175 (KC1A_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Casein kinase I isoform alpha
Short name=CKI-alpha
EC=2.7.11.1

Alternative name(s):
CK1

Gene names

Name:

CSNK1A1

Organism

Sus scrofa (Pig) [Complete proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	125 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May play a role in segregating chromosomes during mitosis By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subunit structure	Monomer. Interacts with the Axin complex. Interacts with TUT1, leading to TUT1 phosphorylation By similarity.
Subcellular location	Cytoplasm By similarity. Cytoplasm › cytoskeleton › centrosome By similarity. Chromosome › centromere › kinetochore By similarity. Nucleus speckle By similarity. Note: Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis Wnt signaling pathway
Cellular component	Centromere Chromosome Cytoplasm Cytoskeleton Kinetochore Nucleus
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	condensed chromosome kinetochore Inferred from electronic annotation. Source: UniProtKB-SubCell microtubule organizing center Inferred from electronic annotation. Source: UniProtKB-SubCell nuclear speck Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›125	›125	Casein kinase I isoform alpha		PRO_0000192824
Regions
	Domain	‹1 – ›125	›125	Protein kinase
Sites
	Active site	97	1	Proton acceptor By similarity
	Binding site	7	1	ATP By similarity
Amino acid modifications
	Modified residue	66	1	Phosphoserine By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	125	1

Sequences

	Sequence		Length	Mass (Da)
	O19175 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: EB44429E8A2FC7A5	FASTA	125	14,633
	10 20 30 40 50 60 GEEVAVKLES QKARHPQLLY ESKLYKILQG GVGIPHIRWY GQEKDYNVLV MDLLGPSLED 70 80 90 100 110 120 LFNFCSRRFT MKTVLMLADQ MISRIEYVHT KNFIHRDIKP DNFLMGIGRH CNKLFLIDFG LAKKY

References

[1]	"Evaluation and characterization of a porcine small intestine cDNA library: analysis of 839 clones." Winteroe A.K., Fredholm M., Davies W. Mamm. Genome 7:509-517(1996) [PubMed: 8672129] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Small intestine.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	F22872 mRNA. Translation: CAA23396.1.
3D structure databases
ProteinModelPortal	O19175.
SMR	O19175. Positions 1-125.
ModBase	Search...
Protein-protein interaction databases
STRING	O19175.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
GeneTree	ENSGT00560000076651.
HOVERGEN	HBG000176.
OrthoDB	EOG41JZCH.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017442. Se/Thr_kinase-like_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. Partial match. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	O19175.

Entry information

Entry name

KC1A_PIG

Accession

Primary (citable) accession number: O19175

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	January 1, 1998
Last modified:	July 27, 2011
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program