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Protein

Tumor necrosis factor receptor superfamily member 1A

Gene

TNFRSF1A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 1A
Alternative name(s):
Tumor necrosis factor receptor 1
Short name:
TNF-R1
Tumor necrosis factor receptor type I
Short name:
TNF-RI
Short name:
TNFR-I
p55
p60
CD_antigen: CD120a
Gene namesi
Name:TNFRSF1A
Synonyms:TNFR1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 210ExtracellularSequence analysisAdd BLAST181
Transmembranei211 – 233HelicalSequence analysisAdd BLAST23
Topological domaini234 – 471CytoplasmicSequence analysisAdd BLAST238

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29By similarityAdd BLAST29
ChainiPRO_000003454230 – 471Tumor necrosis factor receptor superfamily member 1AAdd BLAST442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 58PROSITE-ProRule annotation
Glycosylationi54N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi59 ↔ 72PROSITE-ProRule annotation
Disulfide bondi62 ↔ 81PROSITE-ProRule annotation
Disulfide bondi84 ↔ 99PROSITE-ProRule annotation
Disulfide bondi102 ↔ 117PROSITE-ProRule annotation
Disulfide bondi105 ↔ 125PROSITE-ProRule annotation
Disulfide bondi127 ↔ 143PROSITE-ProRule annotation
Glycosylationi145N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi146 ↔ 158PROSITE-ProRule annotation
Disulfide bondi149 ↔ 166PROSITE-ProRule annotation
Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi168 ↔ 179PROSITE-ProRule annotation
Disulfide bondi182 ↔ 194PROSITE-ProRule annotation
Disulfide bondi185 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO19131
PRIDEiO19131

Interactioni

Subunit structurei

Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BABAM2, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts directly with NOL3 (via CARD domain); inhibits TNF-signaling pathway (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005522

Structurei

3D structure databases

ProteinModelPortaliO19131
SMRiO19131
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati43 – 82TNFR-Cys 1Add BLAST40
Repeati83 – 125TNFR-Cys 2Add BLAST43
Repeati126 – 166TNFR-Cys 3Add BLAST41
Repeati167 – 195TNFR-Cys 4Add BLAST29
Domaini372 – 457DeathPROSITE-ProRule annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni340 – 360N-SMase activation domain (NSD)Add BLAST21

Domaini

Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXBX Eukaryota
ENOG4111YG2 LUCA
HOGENOMiHOG000133001
HOVERGENiHBG058842
InParanoidiO19131
KOiK03158

Family and domain databases

CDDicd08313 Death_TNFR1, 1 hit
cd10576 TNFRSF1A, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020419 TNFR_1A
IPR033994 TNFRSF1A_death
IPR033993 TNFRSF1A_N
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00020 TNFR_c6, 2 hits
PRINTSiPR01918 TNFACTORR1A
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00208 TNFR, 3 hits
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS00652 TNFR_NGFR_1, 3 hits
PS50050 TNFR_NGFR_2, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O19131-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPTVPGLL LPLVLPALLA DVYPAGVQGL VPHPGDLEKR ESPCPQGKYN
60 70 80 90 100
HPQNSTICCT KCHKGTYLYN DCPGPGRDTD CRVCAPGTYT ALENHLRRCL
110 120 130 140 150
SCSRCRDEMF QVEISPCVVD RDTVCGCRKN QYREYWGETG FRCLNCSLCP
160 170 180 190 200
NGTVNIPCQE RQDTICHCHM GFFLKGAKCI SCHDCKNKEC EKLCPTRPST
210 220 230 240 250
GKDSQDPGTT VLLPLVIVFG LCLASFASVV LACRYQRWKP KLYSIICGQS
260 270 280 290 300
TLVKEGEPEL LVPAPGFNPT TTICFSSTPS SSPVSIPPYI SCDRSNFGAV
310 320 330 340 350
ASPSSETAPP HLKAGPILPG PPASTHLCTP GPPASTHLCT PGPPASTHLC
360 370 380 390 400
TPVQKWEASA PSAPDQLADA DPATLYAVVD GVPPSRWKEL VRRLGLSEHE
410 420 430 440 450
IERLELENGR HLREAQYSML AAWRRRTPRR EATLELLGRV LRDMDLLGCL
460 470
ENIEEALGGA ARLASEPRLL W
Length:471
Mass (Da):51,368
Last modified:January 1, 1998 - v1
Checksum:i5243EF514DFE81C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90937 mRNA Translation: AAB65143.1
BC113278 mRNA Translation: AAI13279.1
RefSeqiNP_777099.1, NM_174674.2
UniGeneiBt.3890

Genome annotation databases

GeneIDi282527
KEGGibta:282527

Similar proteinsi

Entry informationi

Entry nameiTNR1A_BOVIN
AccessioniPrimary (citable) accession number: O19131
Secondary accession number(s): Q2HJ72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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