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Protein

Tumor necrosis factor receptor superfamily member 1A

Gene

TNFRSF1A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 1A
Alternative name(s):
Tumor necrosis factor receptor 1
Short name:
TNF-R1
Tumor necrosis factor receptor type I
Short name:
TNF-RI
Short name:
TNFR-I
p55
p60
CD_antigen: CD120a
Gene namesi
Name:TNFRSF1A
Synonyms:TNFR1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 210189ExtracellularSequence analysisAdd
BLAST
Transmembranei211 – 23323HelicalSequence analysisAdd
BLAST
Topological domaini234 – 471238CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 471450Tumor necrosis factor receptor superfamily member 1APRO_0000034542Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi44 ↔ 58PROSITE-ProRule annotation
Glycosylationi54 – 541N-linked (GlcNAc...)Sequence analysis
Disulfide bondi59 ↔ 72PROSITE-ProRule annotation
Disulfide bondi62 ↔ 81PROSITE-ProRule annotation
Disulfide bondi84 ↔ 99PROSITE-ProRule annotation
Disulfide bondi102 ↔ 117PROSITE-ProRule annotation
Disulfide bondi105 ↔ 125PROSITE-ProRule annotation
Disulfide bondi127 ↔ 143PROSITE-ProRule annotation
Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence analysis
Disulfide bondi146 ↔ 158PROSITE-ProRule annotation
Disulfide bondi149 ↔ 166PROSITE-ProRule annotation
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence analysis
Disulfide bondi168 ↔ 179PROSITE-ProRule annotation
Disulfide bondi182 ↔ 194PROSITE-ProRule annotation
Disulfide bondi185 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO19131.
PRIDEiO19131.

Interactioni

Subunit structurei

Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BRE, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts directly with NOL3 (via CARD domain); inhibits TNF-signaling pathway (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005522.

Structurei

3D structure databases

ProteinModelPortaliO19131.
SMRiO19131. Positions 372-457.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati43 – 8240TNFR-Cys 1Add
BLAST
Repeati83 – 12543TNFR-Cys 2Add
BLAST
Repeati126 – 16641TNFR-Cys 3Add
BLAST
Repeati167 – 19529TNFR-Cys 4Add
BLAST
Domaini372 – 45786DeathPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni340 – 36021N-SMase activation domain (NSD)Add
BLAST

Domaini

Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.By similarity

Sequence similaritiesi

Contains 1 death domain.PROSITE-ProRule annotation
Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXBX. Eukaryota.
ENOG4111YG2. LUCA.
HOGENOMiHOG000133001.
HOVERGENiHBG058842.
InParanoidiO19131.
KOiK03158.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020419. TNFR_1A.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01918. TNFACTORR1A.
SMARTiSM00005. DEATH. 1 hit.
SM00208. TNFR. 3 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O19131-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPTVPGLL LPLVLPALLA DVYPAGVQGL VPHPGDLEKR ESPCPQGKYN
60 70 80 90 100
HPQNSTICCT KCHKGTYLYN DCPGPGRDTD CRVCAPGTYT ALENHLRRCL
110 120 130 140 150
SCSRCRDEMF QVEISPCVVD RDTVCGCRKN QYREYWGETG FRCLNCSLCP
160 170 180 190 200
NGTVNIPCQE RQDTICHCHM GFFLKGAKCI SCHDCKNKEC EKLCPTRPST
210 220 230 240 250
GKDSQDPGTT VLLPLVIVFG LCLASFASVV LACRYQRWKP KLYSIICGQS
260 270 280 290 300
TLVKEGEPEL LVPAPGFNPT TTICFSSTPS SSPVSIPPYI SCDRSNFGAV
310 320 330 340 350
ASPSSETAPP HLKAGPILPG PPASTHLCTP GPPASTHLCT PGPPASTHLC
360 370 380 390 400
TPVQKWEASA PSAPDQLADA DPATLYAVVD GVPPSRWKEL VRRLGLSEHE
410 420 430 440 450
IERLELENGR HLREAQYSML AAWRRRTPRR EATLELLGRV LRDMDLLGCL
460 470
ENIEEALGGA ARLASEPRLL W
Length:471
Mass (Da):51,368
Last modified:January 1, 1998 - v1
Checksum:i5243EF514DFE81C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90937 mRNA. Translation: AAB65143.1.
BC113278 mRNA. Translation: AAI13279.1.
RefSeqiNP_777099.1. NM_174674.2.
UniGeneiBt.3890.

Genome annotation databases

GeneIDi282527.
KEGGibta:282527.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90937 mRNA. Translation: AAB65143.1.
BC113278 mRNA. Translation: AAI13279.1.
RefSeqiNP_777099.1. NM_174674.2.
UniGeneiBt.3890.

3D structure databases

ProteinModelPortaliO19131.
SMRiO19131. Positions 372-457.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005522.

Proteomic databases

PaxDbiO19131.
PRIDEiO19131.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi282527.
KEGGibta:282527.

Organism-specific databases

CTDi7132.

Phylogenomic databases

eggNOGiENOG410IXBX. Eukaryota.
ENOG4111YG2. LUCA.
HOGENOMiHOG000133001.
HOVERGENiHBG058842.
InParanoidiO19131.
KOiK03158.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020419. TNFR_1A.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01918. TNFACTORR1A.
SMARTiSM00005. DEATH. 1 hit.
SM00208. TNFR. 3 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNR1A_BOVIN
AccessioniPrimary (citable) accession number: O19131
Secondary accession number(s): Q2HJ72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.