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Protein

Secreted frizzled-related protein 1

Gene

SFRP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription.By similarity

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton organization Source: MGI
  • canonical Wnt signaling pathway Source: GO_Central
  • multicellular organism development Source: UniProtKB-KW
  • non-canonical Wnt signaling pathway Source: GO_Central
  • positive regulation of cell-matrix adhesion Source: BHF-UCL
  • positive regulation of focal adhesion assembly Source: BHF-UCL
  • positive regulation of GTPase activity Source: BHF-UCL
  • positive regulation of stress fiber assembly Source: BHF-UCL
  • regulation of angiogenesis Source: BHF-UCL
  • substrate adhesion-dependent cell spreading Source: MGI

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Wnt signaling pathway

Protein family/group databases

MEROPSiI93.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted frizzled-related protein 1
Short name:
sFRP-1
Alternative name(s):
Frizzled in aorta protein
Short name:
FrzA protein
Gene namesi
Name:SFRP1
Synonyms:FRZA
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000003253726 – 308Secreted frizzled-related protein 1Add BLAST283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 115By similarity
Disulfide bondi62 ↔ 108By similarity
Disulfide bondi99 ↔ 134By similarity
Disulfide bondi123 ↔ 160By similarity
Disulfide bondi127 ↔ 151By similarity
Glycosylationi167N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi180 ↔ 250By similarity
Disulfide bondi183 ↔ 252By similarity
Disulfide bondi197 ↔ 300By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO19116.
PRIDEiO19116.

Expressioni

Tissue specificityi

Highest levels in aortic endothelium, heart, spleen and eye. Lower levels in lung, brain and kidney. Weak expression in liver, skeletal muscle and the medial layer of the aorta. In the cortical brain, localized to neurons and small blood vessels. In the retina, localized to the inner and outer nuclear layers with high expression in the neuronal cell bodies. In the heart, restricted to myocytes. In lung, highest expression found in the epithelium of terminal bronchioles. In kidney, localized to the epithelium of collecting ducts of the medulla and, in spleen, expression restricted to the red pulp in cells associated with the sinuses.1 Publication

Interactioni

Subunit structurei

Interacts with WNT1, WNT2, WNT4, WNT8, MYOC and FRZD6.By similarity

GO - Molecular functioni

  • frizzled binding Source: BHF-UCL
  • Wnt-protein binding Source: GO_Central

Protein-protein interaction databases

BioGridi159350. 2 interactors.
STRINGi9913.ENSBTAP00000039575.

Structurei

3D structure databases

ProteinModelPortaliO19116.
SMRiO19116.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 163FZPROSITE-ProRule annotationAdd BLAST117
Domaini180 – 300NTRPROSITE-ProRule annotationAdd BLAST121

Domaini

The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
HOGENOMiHOG000231058.
HOVERGENiHBG052928.
InParanoidiO19116.
KOiK02166.

Family and domain databases

InterProiView protein in InterPro
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR026559. SFRP1.
IPR008993. TIMP-like_OB-fold.
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF101. PTHR11309:SF101. 1 hit.
PfamiView protein in Pfam
PF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
SMARTiView protein in SMART
SM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
SUPFAMiSSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEiView protein in PROSITE
PS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O19116-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGGRWAAAG ALLALAAGLL AAGSASEYDY VSFQSDIGAY QSGRFYTKPP
60 70 80 90 100
QCVDIPADLR LCHNVGYKRM VLPNLLEHET MAEVKQQASS WVPLLNKNCH
110 120 130 140 150
IGTQVFLCSL FAPVCLDRPI YPCRWLCEAV RDSCEPVMQF FGFYWPEMLK
160 170 180 190 200
CDKFPEGDVC IAMTPPNATE ASKPQGTTVC PPCDNELKSE AIIEHLCASE
210 220 230 240 250
FALRMKIKEV KKENGDKKIV PKKKKPLKLG PIKKKELKKL VLYLKNGADC
260 270 280 290 300
PCHQLDNLSH HFLIMGRKVK SQYLLTAIHK WDKKNKEFKT FMKKMKNHEC

PTFQSVFK
Length:308
Mass (Da):34,763
Last modified:January 1, 1998 - v1
Checksum:i184D138B31123FEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85945 mRNA. Translation: AAB67062.1.
RefSeqiNP_776885.1. NM_174460.2.
UniGeneiBt.5226.

Genome annotation databases

GeneIDi282068.
KEGGibta:282068.

Similar proteinsi

Entry informationi

Entry nameiSFRP1_BOVIN
AccessioniPrimary (citable) accession number: O19116
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: January 1, 1998
Last modified: August 30, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families