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O19116

- SFRP1_BOVIN

UniProt

O19116 - SFRP1_BOVIN

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Protein

Secreted frizzled-related protein 1

Gene

SFRP1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription.By similarity

GO - Molecular functioni

  1. frizzled binding Source: BHF-UCL
  2. PDZ domain binding Source: RefGenome
  3. Wnt-activated receptor activity Source: RefGenome
  4. Wnt-protein binding Source: RefGenome

GO - Biological processi

  1. actin cytoskeleton organization Source: MGI
  2. brain development Source: RefGenome
  3. canonical Wnt signaling pathway Source: RefGenome
  4. gonad development Source: RefGenome
  5. positive regulation of cell-matrix adhesion Source: BHF-UCL
  6. positive regulation of focal adhesion assembly Source: BHF-UCL
  7. positive regulation of Rac GTPase activity Source: BHF-UCL
  8. positive regulation of stress fiber assembly Source: BHF-UCL
  9. regulation of angiogenesis Source: BHF-UCL
  10. substrate adhesion-dependent cell spreading Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Wnt signaling pathway

Protein family/group databases

MEROPSiI93.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted frizzled-related protein 1
Short name:
sFRP-1
Alternative name(s):
Frizzled in aorta protein
Short name:
FrzA protein
Gene namesi
Name:SFRP1
Synonyms:FRZA
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Secreted 1 Publication
Note: Cell membrane or extracellular matrix-associated. Released by heparin-binding.

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. extracellular space Source: BHF-UCL
  3. plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 308283Secreted frizzled-related protein 1PRO_0000032537Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi52 ↔ 115By similarity
Disulfide bondi62 ↔ 108By similarity
Disulfide bondi99 ↔ 134By similarity
Disulfide bondi123 ↔ 160By similarity
Disulfide bondi127 ↔ 151By similarity
Glycosylationi167 – 1671N-linked (GlcNAc...)By similarity
Disulfide bondi180 ↔ 250By similarity
Disulfide bondi183 ↔ 252By similarity
Disulfide bondi197 ↔ 300By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO19116.

Expressioni

Tissue specificityi

Highest levels in aortic endothelium, heart, spleen and eye. Lower levels in lung, brain and kidney. Weak expression in liver, skeletal muscle and the medial layer of the aorta. In the cortical brain, localized to neurons and small blood vessels. In the retina, localized to the inner and outer nuclear layers with high expression in the neuronal cell bodies. In the heart, restricted to myocytes. In lung, highest expression found in the epithelium of terminal bronchioles. In kidney, localized to the epithelium of collecting ducts of the medulla and, in spleen, expression restricted to the red pulp in cells associated with the sinuses.1 Publication

Interactioni

Subunit structurei

Interacts with WNT1, WNT2, WNT4, WNT8, MYOC and FRZD6.By similarity

Protein-protein interaction databases

BioGridi159350. 2 interactions.
STRINGi9913.ENSBTAP00000039575.

Structurei

3D structure databases

ProteinModelPortaliO19116.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 163117FZPROSITE-ProRule annotationAdd
BLAST
Domaini180 – 300121NTRPROSITE-ProRule annotationAdd
BLAST

Domaini

The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation
Contains 1 NTR domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG240950.
HOGENOMiHOG000231058.
HOVERGENiHBG052928.
InParanoidiO19116.
KOiK02166.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR026559. SFRP1.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF46. PTHR11309:SF46. 1 hit.
PfamiPF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O19116-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGGGRWAAAG ALLALAAGLL AAGSASEYDY VSFQSDIGAY QSGRFYTKPP
60 70 80 90 100
QCVDIPADLR LCHNVGYKRM VLPNLLEHET MAEVKQQASS WVPLLNKNCH
110 120 130 140 150
IGTQVFLCSL FAPVCLDRPI YPCRWLCEAV RDSCEPVMQF FGFYWPEMLK
160 170 180 190 200
CDKFPEGDVC IAMTPPNATE ASKPQGTTVC PPCDNELKSE AIIEHLCASE
210 220 230 240 250
FALRMKIKEV KKENGDKKIV PKKKKPLKLG PIKKKELKKL VLYLKNGADC
260 270 280 290 300
PCHQLDNLSH HFLIMGRKVK SQYLLTAIHK WDKKNKEFKT FMKKMKNHEC

PTFQSVFK
Length:308
Mass (Da):34,763
Last modified:January 1, 1998 - v1
Checksum:i184D138B31123FEB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U85945 mRNA. Translation: AAB67062.1.
RefSeqiNP_776885.1. NM_174460.2.
UniGeneiBt.5226.

Genome annotation databases

GeneIDi282068.
KEGGibta:282068.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U85945 mRNA. Translation: AAB67062.1 .
RefSeqi NP_776885.1. NM_174460.2.
UniGenei Bt.5226.

3D structure databases

ProteinModelPortali O19116.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 159350. 2 interactions.
STRINGi 9913.ENSBTAP00000039575.

Protein family/group databases

MEROPSi I93.001.

Proteomic databases

PRIDEi O19116.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 282068.
KEGGi bta:282068.

Organism-specific databases

CTDi 6422.

Phylogenomic databases

eggNOGi NOG240950.
HOGENOMi HOG000231058.
HOVERGENi HBG052928.
InParanoidi O19116.
KOi K02166.

Miscellaneous databases

NextBioi 20805919.

Family and domain databases

Gene3Di 1.10.2000.10. 1 hit.
InterProi IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR026559. SFRP1.
IPR008993. TIMP-like_OB-fold.
[Graphical view ]
PANTHERi PTHR11309. PTHR11309. 1 hit.
PTHR11309:SF46. PTHR11309:SF46. 1 hit.
Pfami PF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view ]
SMARTi SM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view ]
SUPFAMi SSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEi PS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification and cloning of a secreted protein related to the cysteine-rich domain of frizzled: evidence for a role in endothelial cell growth control."
    Duplaa C., Jaspard B., Moreau C., D'Amore P.A.
    Circ. Res. 84:1433-1445(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Aortic endothelium.

Entry informationi

Entry nameiSFRP1_BOVIN
AccessioniPrimary (citable) accession number: O19116
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: January 1, 1998
Last modified: October 1, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3