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O19116

- SFRP1_BOVIN

UniProt

O19116 - SFRP1_BOVIN

Protein

Secreted frizzled-related protein 1

Gene

SFRP1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels By similarity. Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase By similarity. In kidney development, inhibits tubule formation and bud growth in metanephroi By similarity. Inhibits WNT1/WNT4-mediated TCF-dependent transcription.By similarity

    GO - Molecular functioni

    1. frizzled binding Source: BHF-UCL
    2. PDZ domain binding Source: RefGenome
    3. Wnt-activated receptor activity Source: RefGenome
    4. Wnt-protein binding Source: RefGenome

    GO - Biological processi

    1. actin cytoskeleton organization Source: MGI
    2. brain development Source: RefGenome
    3. canonical Wnt signaling pathway Source: RefGenome
    4. gonad development Source: RefGenome
    5. positive regulation of cell-matrix adhesion Source: BHF-UCL
    6. positive regulation of focal adhesion assembly Source: BHF-UCL
    7. positive regulation of Rac GTPase activity Source: BHF-UCL
    8. positive regulation of stress fiber assembly Source: BHF-UCL
    9. regulation of angiogenesis Source: BHF-UCL
    10. substrate adhesion-dependent cell spreading Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Wnt signaling pathway

    Protein family/group databases

    MEROPSiI93.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Secreted frizzled-related protein 1
    Short name:
    sFRP-1
    Alternative name(s):
    Frizzled in aorta protein
    Short name:
    FrzA protein
    Gene namesi
    Name:SFRP1
    Synonyms:FRZA
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Secreted 1 Publication
    Note: Cell membrane or extracellular matrix-associated. Released by heparin-binding.

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. extracellular space Source: BHF-UCL
    3. plasma membrane Source: BHF-UCL

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 308283Secreted frizzled-related protein 1PRO_0000032537Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi52 ↔ 115By similarity
    Disulfide bondi62 ↔ 108By similarity
    Disulfide bondi99 ↔ 134By similarity
    Disulfide bondi123 ↔ 160By similarity
    Disulfide bondi127 ↔ 151By similarity
    Glycosylationi167 – 1671N-linked (GlcNAc...)By similarity
    Disulfide bondi180 ↔ 250By similarity
    Disulfide bondi183 ↔ 252By similarity
    Disulfide bondi197 ↔ 300By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiO19116.

    Expressioni

    Tissue specificityi

    Highest levels in aortic endothelium, heart, spleen and eye. Lower levels in lung, brain and kidney. Weak expression in liver, skeletal muscle and the medial layer of the aorta. In the cortical brain, localized to neurons and small blood vessels. In the retina, localized to the inner and outer nuclear layers with high expression in the neuronal cell bodies. In the heart, restricted to myocytes. In lung, highest expression found in the epithelium of terminal bronchioles. In kidney, localized to the epithelium of collecting ducts of the medulla and, in spleen, expression restricted to the red pulp in cells associated with the sinuses.1 Publication

    Interactioni

    Subunit structurei

    Interacts with WNT1, WNT2, WNT4, WNT8, MYOC and FRZD6.By similarity

    Protein-protein interaction databases

    BioGridi159350. 2 interactions.
    STRINGi9913.ENSBTAP00000039575.

    Structurei

    3D structure databases

    ProteinModelPortaliO19116.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini47 – 163117FZPROSITE-ProRule annotationAdd
    BLAST
    Domaini180 – 300121NTRPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The FZ domain is involved in binding with Wnt ligands.By similarity

    Sequence similaritiesi

    Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation
    Contains 1 NTR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG240950.
    HOGENOMiHOG000231058.
    HOVERGENiHBG052928.
    InParanoidiO19116.
    KOiK02166.

    Family and domain databases

    Gene3Di1.10.2000.10. 1 hit.
    InterProiIPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR001134. Netrin_domain.
    IPR018933. Netrin_module_non-TIMP.
    IPR026559. SFRP1.
    IPR008993. TIMP-like_OB-fold.
    [Graphical view]
    PANTHERiPTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF46. PTHR11309:SF46. 1 hit.
    PfamiPF01392. Fz. 1 hit.
    PF01759. NTR. 1 hit.
    [Graphical view]
    SMARTiSM00643. C345C. 1 hit.
    SM00063. FRI. 1 hit.
    [Graphical view]
    SUPFAMiSSF50242. SSF50242. 1 hit.
    SSF63501. SSF63501. 1 hit.
    PROSITEiPS50038. FZ. 1 hit.
    PS50189. NTR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O19116-1 [UniParc]FASTAAdd to Basket

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    MGGGRWAAAG ALLALAAGLL AAGSASEYDY VSFQSDIGAY QSGRFYTKPP    50
    QCVDIPADLR LCHNVGYKRM VLPNLLEHET MAEVKQQASS WVPLLNKNCH 100
    IGTQVFLCSL FAPVCLDRPI YPCRWLCEAV RDSCEPVMQF FGFYWPEMLK 150
    CDKFPEGDVC IAMTPPNATE ASKPQGTTVC PPCDNELKSE AIIEHLCASE 200
    FALRMKIKEV KKENGDKKIV PKKKKPLKLG PIKKKELKKL VLYLKNGADC 250
    PCHQLDNLSH HFLIMGRKVK SQYLLTAIHK WDKKNKEFKT FMKKMKNHEC 300
    PTFQSVFK 308
    Length:308
    Mass (Da):34,763
    Last modified:January 1, 1998 - v1
    Checksum:i184D138B31123FEB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U85945 mRNA. Translation: AAB67062.1.
    RefSeqiNP_776885.1. NM_174460.2.
    UniGeneiBt.5226.

    Genome annotation databases

    GeneIDi282068.
    KEGGibta:282068.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U85945 mRNA. Translation: AAB67062.1 .
    RefSeqi NP_776885.1. NM_174460.2.
    UniGenei Bt.5226.

    3D structure databases

    ProteinModelPortali O19116.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 159350. 2 interactions.
    STRINGi 9913.ENSBTAP00000039575.

    Protein family/group databases

    MEROPSi I93.001.

    Proteomic databases

    PRIDEi O19116.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 282068.
    KEGGi bta:282068.

    Organism-specific databases

    CTDi 6422.

    Phylogenomic databases

    eggNOGi NOG240950.
    HOGENOMi HOG000231058.
    HOVERGENi HBG052928.
    InParanoidi O19116.
    KOi K02166.

    Miscellaneous databases

    NextBioi 20805919.

    Family and domain databases

    Gene3Di 1.10.2000.10. 1 hit.
    InterProi IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR001134. Netrin_domain.
    IPR018933. Netrin_module_non-TIMP.
    IPR026559. SFRP1.
    IPR008993. TIMP-like_OB-fold.
    [Graphical view ]
    PANTHERi PTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF46. PTHR11309:SF46. 1 hit.
    Pfami PF01392. Fz. 1 hit.
    PF01759. NTR. 1 hit.
    [Graphical view ]
    SMARTi SM00643. C345C. 1 hit.
    SM00063. FRI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50242. SSF50242. 1 hit.
    SSF63501. SSF63501. 1 hit.
    PROSITEi PS50038. FZ. 1 hit.
    PS50189. NTR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and cloning of a secreted protein related to the cysteine-rich domain of frizzled: evidence for a role in endothelial cell growth control."
      Duplaa C., Jaspard B., Moreau C., D'Amore P.A.
      Circ. Res. 84:1433-1445(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Aortic endothelium.

    Entry informationi

    Entry nameiSFRP1_BOVIN
    AccessioniPrimary (citable) accession number: O19116
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3