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O19113 (CTGF_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Connective tissue growth factor
Alternative name(s):
CCN family member 2
Gene names
Name:CTGF
Synonyms:CCN2
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes By similarity. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells By similarity. Enhances fibroblast growth factor-induced DNA synthesis By similarity.

Subunit structure

Monomer By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity. Secreted By similarity.

Sequence similarities

Belongs to the CCN family.

Contains 1 CTCK (C-terminal cystine knot-like) domain.

Contains 1 IGFBP N-terminal domain.

Contains 1 TSP type-1 domain.

Contains 1 VWFC domain.

Ontologies

Keywords
   Biological processCell adhesion
DNA synthesis
   Cellular componentExtracellular matrix
Secreted
   DomainSignal
   LigandHeparin-binding
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

cell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

regulation of cell growth

Inferred from electronic annotation. Source: InterPro

   Cellular_componentproteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionheparin binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 349323Connective tissue growth factor
PRO_0000014404

Regions

Domain27 – 9872IGFBP N-terminal
Domain101 – 16767VWFC
Domain198 – 24346TSP type-1
Domain256 – 33075CTCK
Region247 – 349103Heparin-binding By similarity

Amino acid modifications

Disulfide bond256 ↔ 293 By similarity
Disulfide bond273 ↔ 307 By similarity
Disulfide bond284 ↔ 323 By similarity
Disulfide bond287 ↔ 325 By similarity
Disulfide bond292 ↔ 329 By similarity

Sequences

Sequence LengthMass (Da)Tools
O19113 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: BB510E2B2B52D4A0

FASTA34938,007
        10         20         30         40         50         60 
MSATGLSPVR CAFVLLLALC SRPASGQDCS GQCQCAAGKR RACPAGVSLV LDGCGCCRLC 

        70         80         90        100        110        120 
AKQLGELCTE RDPCDPHKGL FCDFGSPANR KIGVCTAKDG APCVFGGTVY RSGESFQSSC 

       130        140        150        160        170        180 
KYQCTCLDGA VGCVPLCSMD VRLPSPDCPF PRRVKLPGKC CEEWVCDEPK DHTVVGPALA 

       190        200        210        220        230        240 
AYRLEDTFGP DPTMMRANCL VQTTEWSACS KTCGMGISTR VTNDNAFCRL EKQSRLCMVR 

       250        260        270        280        290        300 
PCEADLEENI KKGKKCIRTP KISKPVKFEL SGCTSVKTYR AKFCGVCTDG RCCTPHRTTT 

       310        320        330        340 
LPVEFKCPDG EVMKKSMMFI KTCACHYNCP GDNDIFESLY YRKMYGDMA 

« Hide

References

[1]"Purification and characterization of novel heparin-binding growth factors in uterine secretory fluids. Identification as heparin-regulated Mr 10,000 forms of connective tissue growth factor."
Brigstock D.R., Steffen C.L., Kim G.Y., Vegunta R.K., Diehl J.R., Harding P.A.
J. Biol. Chem. 272:20275-20282(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Uterus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U83916 mRNA. Translation: AAC48756.1.
UniGeneSsc.70001.

3D structure databases

ProteinModelPortalO19113.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEO19113.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG72934.
HOGENOMHOG000231462.
HOVERGENHBG000635.

Family and domain databases

InterProIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCTGF_PIG
AccessionPrimary (citable) accession number: O19113
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families