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Protein

Neutral amino acid transporter B(0)

Gene

SLC1A5

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Neutral amino acid transporter B(0)
Short name:
ATB(0)
Alternative name(s):
Sodium-dependent neutral amino acid transporter type 2
Solute carrier family 1 member 5
Gene namesi
Name:SLC1A5
Synonyms:ASCT2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 53CytoplasmicSequence analysisAdd BLAST53
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei134 – 154HelicalSequence analysisAdd BLAST21
Topological domaini155 – 225ExtracellularSequence analysisAdd BLAST71
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
Transmembranei307 – 327HelicalSequence analysisAdd BLAST21
Transmembranei337 – 357HelicalSequence analysisAdd BLAST21
Transmembranei378 – 398HelicalSequence analysisAdd BLAST21
Transmembranei400 – 420HelicalSequence analysisAdd BLAST21
Transmembranei427 – 447HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002020841 – 541Neutral amino acid transporter B(0)Add BLAST541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Glycosylationi164N-linked (GlcNAc...)Sequence analysis1
Glycosylationi215N-linked (GlcNAc...)Sequence analysis1
Modified residuei495PhosphoserineBy similarity1
Modified residuei504PhosphoserineBy similarity1
Modified residuei539PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliO19105.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG000080.
InParanoidiO19105.
KOiK05616.

Family and domain databases

Gene3Di1.10.3860.10. 1 hit.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O19105-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVADPPKGDP KGLAAVEPTA NGAPAQDPLE DSGAAVGRCC SSRDQVRRCL
60 70 80 90 100
RANLLVLLTV VAVVAGVALG LAVSGAGGAL ALGPARLIAF AFPGELLLRL
110 120 130 140 150
LKMIILPLVV CSLVGGAASL DPSALGRLGA WALLFFLVTT LLASALGVGL
160 170 180 190 200
ALALQPGAAF AAMNASLSST GAVEQTPSKQ VLDSFLDLLR NIFPSNLVSA
210 220 230 240 250
AFRSYSTSYE EKNFNGTLVK VPVAHEEEGM NILGLVVFAI VFGVALRKLG
260 270 280 290 300
PEGEPLIRFF NSFNDATMVL VSWIMWYAPV GILFLVASKI VEMDDVGVLF
310 320 330 340 350
ASLGKYILCC LLGHAIHGLL VLPLIYFLFT RKNPYRFLWG ILTPLAMAFG
360 370 380 390 400
TSSSSATLPL MMKCVEERNG VAKHISRFVL PIGATVNMDG AALFQCVAAV
410 420 430 440 450
FIAQLNRQSL DFVKIITILV TATASSVGAA GIPAGGVLTL AIILEAVSLP
460 470 480 490 500
VSEISLILAV DWLVDRSCTI INVEGDAFGA GLLQHYVDRT EQRGSEPELT
510 520 530 540
QVKSEVPLGS LPAPNEEGNP LLRHSPGAAG DAGACEKESV M
Length:541
Mass (Da):56,658
Last modified:January 1, 1998 - v1
Checksum:i039FAD095091AD15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75284 mRNA. Translation: AAB66298.1.
RefSeqiNP_001075847.1. NM_001082378.1.
UniGeneiOcu.2160.

Genome annotation databases

GeneIDi100009234.
KEGGiocu:100009234.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75284 mRNA. Translation: AAB66298.1.
RefSeqiNP_001075847.1. NM_001082378.1.
UniGeneiOcu.2160.

3D structure databases

ProteinModelPortaliO19105.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009234.
KEGGiocu:100009234.

Organism-specific databases

CTDi6510.

Phylogenomic databases

HOVERGENiHBG000080.
InParanoidiO19105.
KOiK05616.

Family and domain databases

Gene3Di1.10.3860.10. 1 hit.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAAAT_RABIT
AccessioniPrimary (citable) accession number: O19105
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.