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Protein

Fanconi anemia group C protein homolog

Gene

FANCC

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Fanconi anemia group C protein homolog
Short name:
Protein FACC
Gene namesi
Name:FANCC
Synonyms:FACC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: The major form is nuclear. The minor form is cytoplasmic.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 567567Fanconi anemia group C protein homologPRO_0000087183Add
BLAST

Proteomic databases

PaxDbiO19104.
PRIDEiO19104.

Interactioni

Subunit structurei

Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. This complex may also include HSP70. Interacts with ZBTB32. Upon IFNG induction, interacts with STAT1. Interacts with CDK1. Interacts with EIF2AK2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022853.

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IK3Y. Eukaryota.
ENOG411225E. LUCA.
HOVERGENiHBG051548.
InParanoidiO19104.
KOiK10890.

Family and domain databases

InterProiIPR000686. Fanconi.
[Graphical view]
PANTHERiPTHR16798. PTHR16798. 1 hit.
PTHR16798:SF0. PTHR16798:SF0. 1 hit.
PfamiPF02106. Fanconi_C. 1 hit.
[Graphical view]
PIRSFiPIRSF018417. FACC_protein. 1 hit.
PRINTSiPR00494. FANCONICGENE.

Sequencei

Sequence statusi: Complete.

O19104-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEDSAGLPS NYQFWMQKLS VWTQASTLET QRDICLHLPQ FQEFLRRMYE
60 70 80 90 100
TLKEMDSNAI IERFPTICQL LAKSCWSPFI LAYDESPKIL IWCLCCLIKK
110 120 130 140 150
DPQNSRESKL NSWTRRLLSH IVSTSRFDIK EVGLFNQVLG YAPTDYYPGL
160 170 180 190 200
LKNMVLSLVS ELRENHLNGF SSQRRCPERV RSLSRDRVPL LTLPDFEPLV
210 220 230 240 250
EALLTYHGHE PQEVLCPEFF DAVNEASLLK KISLPTSAIL CLWLRHLPSL
260 270 280 290 300
ENTMLHLLEK LISSERNSLR RIKCFMKDSL RPEAAACHPA IFRVVDEIFR
310 320 330 340 350
SALLETDGAP EVLAGLQVFT RCFVEALEKE NKQLKFALKT YFPYASPALV
360 370 380 390 400
MVLLQHPKDI PQGLWHQSLK HISEMLKEIV EDHGSYGGPF ESWFLFVHFG
410 420 430 440 450
GWADITAEQL LMSEAEAEPP EALLWLLAFS CSPGAGHQQR ARTMVEVKTV
460 470 480 490 500
LGCLTKLFRS PALSARDLQA AAGENLGGDP RPPACQQLVR RLLLHFLLWA
510 520 530 540 550
PGGHTIAREV ITLMAQTDAI MNEIIGFLDY TLYRWDHLCV EAHRSRKLAR
560
ELLTELREQA LPGQVNQ
Length:567
Mass (Da):64,721
Last modified:January 1, 1998 - v1
Checksum:iD9B2285E24A177B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73585 mRNA. Translation: AAB66674.1.
RefSeqiNP_776741.1. NM_174316.2.
UniGeneiBt.4648.

Genome annotation databases

GeneIDi281762.
KEGGibta:281762.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73585 mRNA. Translation: AAB66674.1.
RefSeqiNP_776741.1. NM_174316.2.
UniGeneiBt.4648.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022853.

Proteomic databases

PaxDbiO19104.
PRIDEiO19104.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281762.
KEGGibta:281762.

Organism-specific databases

CTDi2176.

Phylogenomic databases

eggNOGiENOG410IK3Y. Eukaryota.
ENOG411225E. LUCA.
HOVERGENiHBG051548.
InParanoidiO19104.
KOiK10890.

Family and domain databases

InterProiIPR000686. Fanconi.
[Graphical view]
PANTHERiPTHR16798. PTHR16798. 1 hit.
PTHR16798:SF0. PTHR16798:SF0. 1 hit.
PfamiPF02106. Fanconi_C. 1 hit.
[Graphical view]
PIRSFiPIRSF018417. FACC_protein. 1 hit.
PRINTSiPR00494. FANCONICGENE.
ProtoNetiSearch...

Entry informationi

Entry nameiFANCC_BOVIN
AccessioniPrimary (citable) accession number: O19104
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: July 6, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.