Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O19103 (UDB16_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 2B16

Short name=UDPGT 2B16
EC=2.4.1.17
Gene names
Name:UGT2B16
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length523 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Acts on small phenolic agents such as 2-beta-naphthol and 4-methylumbelliferone as well as bulky phenolic compounds like 2-hydroxy- and 4-hydroxybiphenyl. In contrast to 2B13 it is active toward 4-hydroxyesterone.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.

Developmental stage

Expressed primarily in adult rabbits.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide‹1 – 16›16
Chain17 – 523507UDP-glucuronosyltransferase 2B16
PRO_0000036040

Regions

Transmembrane487 – 50317Helical; Potential

Amino acid modifications

Glycosylation3091N-linked (GlcNAc...) Potential

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
O19103 [UniParc].

Last modified December 15, 1998. Version 2.
Checksum: 224088E7F68ED3DE

FASTA52360,078
        10         20         30         40         50         60 
LLLLLQLSCC FSSGSCGKVL VWPMEFSHWM NMKTILDALV QRGHAVTVLR SSASILVNSN 

        70         80         90        100        110        120 
DESGITFETF PTTSTKDEME AFFMYWLNKL TNDVSKDALW EYFQTWQKFF MEYSDNYENI 

       130        140        150        160        170        180 
CKDLVLNKKI MAKLQESRFD VVLADPIAPC GELLAELLNR PLVYSVRFTP GYTYEKYSGG 

       190        200        210        220        230        240 
LLFPPSYVPV IMSDLSGQMT FMERVKNMLW MLYFDFWFQM LNVKRWDQFC SEVLGRPVTF 

       250        260        270        280        290        300 
SELVGKAEIW LIRSYWDLEF PRPLLPNSYF VGGLHCKPAQ PLPKEMEEFV QSSGEEGVVV 

       310        320        330        340        350        360 
FSLGSMISNL TEERANVIAS TLAQLPQKVL WKFDGKKPDN LGTNTQLYKW IPQNDLLGHT 

       370        380        390        400        410        420 
VSKAFITHGG ANGVFEAIYH GIPMVGLPLF ADQHDNLAHM RAKGAAIRLD WKTMSSSDFL 

       430        440        450        460        470        480 
NALKTVINDP SYKEKAMTLS RIHHDQPMKP LDQAIFWIEF VMRHKGAKHL RVAAHDLTWF 

       490        500        510        520 
QYHSLDVIGF LLACLTITTY LVIKCWLLVY QNILMTGKKK KRD 

« Hide

References

[1]"Expression and functional domains of rabbit liver UDP-glucuronosyltransferase 2B16 and 2B13."
Li Q., Lou X., Peyronneau M.-A., Straub P.O., Tukey R.H.
J. Biol. Chem. 272:3272-3279(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U72742 mRNA. Translation: AAB71494.1.
UniGeneOcu.2174.

3D structure databases

ProteinModelPortalO19103.
SMRO19103. Positions 279-440.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000025975.

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG1819.
HOGENOMHOG000220831.
HOVERGENHBG004033.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUDB16_RABIT
AccessionPrimary (citable) accession number: O19103
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: May 14, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families