Reviewed, UniProtKB/Swiss-Prot O19103 (UDB16_RABIT)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 2B16
      Short name=UDPGT 2B16
    EC=2.4.1.17

Gene names

Name:

UGT2B16

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	523 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Acts on small phenolic agents such as 2-naphtol and 4-methylumbelliferone as well as bulky phenolic compounds like 2-hydroxy- and 4-hydroxybiphenyl. In contrast to 2B13 it is active toward 4-hydroxyesterone.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Developmental stage	Expressed primarily in adult rabbits.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	‹1 – 16	›16
	Chain	17 – 523	507	UDP-glucuronosyltransferase 2B16		PRO_0000036040
Regions
	Transmembrane	487 – 503	17	Potential
Amino acid modifications
	Glycosylation	309	1	N-linked (GlcNAc...) Potential
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	O19103-1 [UniParc]. Last modified December 15, 1998. Version 2. Checksum: 224088E7F68ED3DE	FASTA	523	60,078
	10 20 30 40 50 60 LLLLLQLSCC FSSGSCGKVL VWPMEFSHWM NMKTILDALV QRGHAVTVLR SSASILVNSN 70 80 90 100 110 120 DESGITFETF PTTSTKDEME AFFMYWLNKL TNDVSKDALW EYFQTWQKFF MEYSDNYENI 130 140 150 160 170 180 CKDLVLNKKI MAKLQESRFD VVLADPIAPC GELLAELLNR PLVYSVRFTP GYTYEKYSGG 190 200 210 220 230 240 LLFPPSYVPV IMSDLSGQMT FMERVKNMLW MLYFDFWFQM LNVKRWDQFC SEVLGRPVTF 250 260 270 280 290 300 SELVGKAEIW LIRSYWDLEF PRPLLPNSYF VGGLHCKPAQ PLPKEMEEFV QSSGEEGVVV 310 320 330 340 350 360 FSLGSMISNL TEERANVIAS TLAQLPQKVL WKFDGKKPDN LGTNTQLYKW IPQNDLLGHT 370 380 390 400 410 420 VSKAFITHGG ANGVFEAIYH GIPMVGLPLF ADQHDNLAHM RAKGAAIRLD WKTMSSSDFL 430 440 450 460 470 480 NALKTVINDP SYKEKAMTLS RIHHDQPMKP LDQAIFWIEF VMRHKGAKHL RVAAHDLTWF 490 500 510 520 QYHSLDVIGF LLACLTITTY LVIKCWLLVY QNILMTGKKK KRD

References

[1]	"Expression and functional domains of rabbit liver UDP-glucuronosyltransferase 2B16 and 2B13." Li Q., Lou X., Peyronneau M.-A., Straub P.O., Tukey R.H. J. Biol. Chem. 272:3272-3279(1997) [PubMed: 9013565] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	U72742 mRNA. Translation: AAB71494.1.
3D structure databases
SMR	O19103. Positions 279-440.
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Phylogenomic databases
HOVERGEN	O19103.
Enzyme and pathway databases
BRENDA	2.4.1.17. 255.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UDB16_RABIT

Accession

Primary (citable) accession number: O19103

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	December 15, 1998
Last modified:	June 16, 2009
This is version 53 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)