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O19103

- UDB16_RABIT

UniProt

O19103 - UDB16_RABIT

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Protein
UDP-glucuronosyltransferase 2B16
Gene
UGT2B16
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Acts on small phenolic agents such as 2-beta-naphthol and 4-methylumbelliferone as well as bulky phenolic compounds like 2-hydroxy- and 4-hydroxybiphenyl. In contrast to 2B13 it is active toward 4-hydroxyesterone.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 2B16 (EC:2.4.1.17)
    Short name:
    UDPGT 2B16
    Gene namesi
    Name:UGT2B16
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei487 – 50317Helical; Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    Complete GO annotation...

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei‹1 – 16›16
    Add
    BLAST
    Chaini17 – 523507UDP-glucuronosyltransferase 2B16
    PRO_0000036040Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi309 – 3091N-linked (GlcNAc...) Reviewed prediction

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Developmental stagei

    Expressed primarily in adult rabbits.

    Interactioni

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000025975.

    Structurei

    3D structure databases

    ProteinModelPortaliO19103.
    SMRiO19103. Positions 279-440.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1819.
    HOGENOMiHOG000220831.
    HOVERGENiHBG004033.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O19103-1 [UniParc]FASTAAdd to Basket

    « Hide

    LLLLLQLSCC FSSGSCGKVL VWPMEFSHWM NMKTILDALV QRGHAVTVLR    50
    SSASILVNSN DESGITFETF PTTSTKDEME AFFMYWLNKL TNDVSKDALW 100
    EYFQTWQKFF MEYSDNYENI CKDLVLNKKI MAKLQESRFD VVLADPIAPC 150
    GELLAELLNR PLVYSVRFTP GYTYEKYSGG LLFPPSYVPV IMSDLSGQMT 200
    FMERVKNMLW MLYFDFWFQM LNVKRWDQFC SEVLGRPVTF SELVGKAEIW 250
    LIRSYWDLEF PRPLLPNSYF VGGLHCKPAQ PLPKEMEEFV QSSGEEGVVV 300
    FSLGSMISNL TEERANVIAS TLAQLPQKVL WKFDGKKPDN LGTNTQLYKW 350
    IPQNDLLGHT VSKAFITHGG ANGVFEAIYH GIPMVGLPLF ADQHDNLAHM 400
    RAKGAAIRLD WKTMSSSDFL NALKTVINDP SYKEKAMTLS RIHHDQPMKP 450
    LDQAIFWIEF VMRHKGAKHL RVAAHDLTWF QYHSLDVIGF LLACLTITTY 500
    LVIKCWLLVY QNILMTGKKK KRD 523
    Length:523
    Mass (Da):60,078
    Last modified:December 15, 1998 - v2
    Checksum:i224088E7F68ED3DE
    GO

    Non-terminal residue

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U72742 mRNA. Translation: AAB71494.1.
    UniGeneiOcu.2174.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U72742 mRNA. Translation: AAB71494.1 .
    UniGenei Ocu.2174.

    3D structure databases

    ProteinModelPortali O19103.
    SMRi O19103. Positions 279-440.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000025975.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG1819.
    HOGENOMi HOG000220831.
    HOVERGENi HBG004033.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression and functional domains of rabbit liver UDP-glucuronosyltransferase 2B16 and 2B13."
      Li Q., Lou X., Peyronneau M.-A., Straub P.O., Tukey R.H.
      J. Biol. Chem. 272:3272-3279(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiUDB16_RABIT
    AccessioniPrimary (citable) accession number: O19103
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: December 15, 1998
    Last modified: May 14, 2014
    This is version 77 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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