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Protein

Cystatin-C

Gene

CST3

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei37Reactive site1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Thiol protease inhibitor

Protein family/group databases

MEROPSiI25.004.

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-C
Alternative name(s):
Cystatin-3
Gene namesi
Name:CST3
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Amyloid, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
ChainiPRO_000000664027 – 146Cystatin-CAdd BLAST120

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43PhosphoserineBy similarity1
Disulfide bondi99 ↔ 109By similarity
Disulfide bondi123 ↔ 143By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Expressioni

Gene expression databases

BgeeiENSMMUG00000009200.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000012060.

Structurei

3D structure databases

ProteinModelPortaliO19092.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi81 – 85Secondary area of contact5

Sequence similaritiesi

Belongs to the cystatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZZH. Eukaryota.
ENOG4112CFJ. LUCA.
GeneTreeiENSGT00860000133739.
HOGENOMiHOG000231754.
HOVERGENiHBG009556.
InParanoidiO19092.
KOiK13899.
OMAiYTVPWLG.
OrthoDBiEOG091G0TP1.

Family and domain databases

CDDicd00042. CY. 1 hit.
InterProiIPR027214. Cystatin.
IPR000010. Cystatin_dom.
IPR018073. Prot_inh_cystat_CS.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 1 hit.
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
SMARTiSM00043. CY. 1 hit.
[Graphical view]
PROSITEiPS00287. CYSTATIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O19092-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPLRAPLL LLAILAVALA VSPAAGASPG KPPRLVGGPM DASVEEEGVR
60 70 80 90 100
RALDFAVSEY NKASNDMYHS RALQVVRARK QIVAGVNYFL DVELGRTTCT
110 120 130 140
KTQPNLDNCP FHEQPHLKRK AFCSFQIYTV PWQGTMTLSK STCQDA
Length:146
Mass (Da):15,857
Last modified:January 1, 1998 - v1
Checksum:iF0B3BB774A29DF26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51912 mRNA. Translation: AAB64050.1.
AY885223 mRNA. Translation: AAW79565.1.
RefSeqiNP_001028096.1. NM_001032924.2.
XP_015005078.1. XM_015149592.1.
UniGeneiMmu.3418.

Genome annotation databases

EnsembliENSMMUT00000064627; ENSMMUP00000055591; ENSMMUG00000040355.
GeneIDi574313.
KEGGimcc:574313.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51912 mRNA. Translation: AAB64050.1.
AY885223 mRNA. Translation: AAW79565.1.
RefSeqiNP_001028096.1. NM_001032924.2.
XP_015005078.1. XM_015149592.1.
UniGeneiMmu.3418.

3D structure databases

ProteinModelPortaliO19092.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000012060.

Protein family/group databases

MEROPSiI25.004.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMMUT00000064627; ENSMMUP00000055591; ENSMMUG00000040355.
GeneIDi574313.
KEGGimcc:574313.

Organism-specific databases

CTDi1471.

Phylogenomic databases

eggNOGiENOG410IZZH. Eukaryota.
ENOG4112CFJ. LUCA.
GeneTreeiENSGT00860000133739.
HOGENOMiHOG000231754.
HOVERGENiHBG009556.
InParanoidiO19092.
KOiK13899.
OMAiYTVPWLG.
OrthoDBiEOG091G0TP1.

Gene expression databases

BgeeiENSMMUG00000009200.

Family and domain databases

CDDicd00042. CY. 1 hit.
InterProiIPR027214. Cystatin.
IPR000010. Cystatin_dom.
IPR018073. Prot_inh_cystat_CS.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 1 hit.
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
SMARTiSM00043. CY. 1 hit.
[Graphical view]
PROSITEiPS00287. CYSTATIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYTC_MACMU
AccessioniPrimary (citable) accession number: O19092
Secondary accession number(s): Q5EG77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.