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Protein

Cystatin-C

Gene

CST3

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei37Reactive site1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor

Protein family/group databases

MEROPSiI25.004.

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-C
Alternative name(s):
Cystatin-3
Gene namesi
Name:CST3
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Amyloid, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
ChainiPRO_000000664027 – 146Cystatin-CAdd BLAST120

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43PhosphoserineBy similarity1
Disulfide bondi99 ↔ 109By similarity
Disulfide bondi123 ↔ 143By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Expressioni

Gene expression databases

BgeeiENSMMUG00000009200.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000012060.

Structurei

3D structure databases

ProteinModelPortaliO19092.
SMRiO19092.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi81 – 85Secondary area of contact5

Sequence similaritiesi

Belongs to the cystatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZZH. Eukaryota.
ENOG4112CFJ. LUCA.
GeneTreeiENSGT00900000140934.
HOGENOMiHOG000231754.
HOVERGENiHBG009556.
InParanoidiO19092.
KOiK13899.
OMAiYTVPWLG.
OrthoDBiEOG091G0TP1.

Family and domain databases

CDDicd00042. CY. 1 hit.
InterProiView protein in InterPro
IPR027214. Cystatin.
IPR000010. Cystatin_dom.
IPR018073. Prot_inh_cystat_CS.
PANTHERiPTHR11413. PTHR11413. 1 hit.
PfamiView protein in Pfam
PF00031. Cystatin. 1 hit.
SMARTiView protein in SMART
SM00043. CY. 1 hit.
PROSITEiView protein in PROSITE
PS00287. CYSTATIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O19092-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPLRAPLL LLAILAVALA VSPAAGASPG KPPRLVGGPM DASVEEEGVR
60 70 80 90 100
RALDFAVSEY NKASNDMYHS RALQVVRARK QIVAGVNYFL DVELGRTTCT
110 120 130 140
KTQPNLDNCP FHEQPHLKRK AFCSFQIYTV PWQGTMTLSK STCQDA
Length:146
Mass (Da):15,857
Last modified:January 1, 1998 - v1
Checksum:iF0B3BB774A29DF26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51912 mRNA. Translation: AAB64050.1.
AY885223 mRNA. Translation: AAW79565.1.
RefSeqiNP_001028096.1. NM_001032924.2.
XP_015005078.1. XM_015149592.1.
UniGeneiMmu.3418.

Genome annotation databases

EnsembliENSMMUT00000064627; ENSMMUP00000055591; ENSMMUG00000040355.
GeneIDi574313.
KEGGimcc:574313.

Similar proteinsi

Entry informationi

Entry nameiCYTC_MACMU
AccessioniPrimary (citable) accession number: O19092
Secondary accession number(s): Q5EG77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: October 25, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families