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Protein

Interleukin-18

Gene

IL18

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.By similarity

GO - Molecular functioni

  • cytokine activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

ReactomeiR-SSC-448706. Interleukin-1 processing.
R-SSC-449147. Signaling by Interleukins.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-18
Short name:
IL-18
Alternative name(s):
Interferon gamma-inducing factor
Short name:
IFN-gamma-inducing factor
Interleukin-1 gamma
Short name:
IL-1 gamma
Gene namesi
Name:IL18
Synonyms:IGIF
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 9

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 3535By similarityPRO_0000015347Add
BLAST
Chaini36 – 192157Interleukin-18PRO_0000015348Add
BLAST

Post-translational modificationi

The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form.By similarity

Proteomic databases

PaxDbiO19073.

Expressioni

Gene expression databases

ExpressionAtlasiO19073. differential.
GenevisibleiO19073. SS.

Interactioni

GO - Molecular functioni

  • cytokine activity Source: UniProtKB

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000015962.

Structurei

3D structure databases

ProteinModelPortaliO19073.
SMRiO19073. Positions 36-192.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410J3U9. Eukaryota.
ENOG410ZGS8. LUCA.
GeneTreeiENSGT00390000001053.
HOGENOMiHOG000048723.
HOVERGENiHBG000388.
InParanoidiO19073.
KOiK05482.
OMAiPVFEDMP.
TreeFamiTF336297.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR015529. IL-18.
IPR000975. IL-1_fam.
[Graphical view]
PANTHERiPTHR11326. PTHR11326. 1 hit.
PfamiPF00340. IL1. 1 hit.
[Graphical view]
PIRSFiPIRSF015162. Interleukin_18. 1 hit.
PRINTSiPR01933. INTRLEUKIN18.
SUPFAMiSSF50353. SSF50353. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O19073-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEPEDNCI SFVEMKFINN TLYFVAENDE DLESDYFGKL EPKLSIIRNL
60 70 80 90 100
NDQVLFINQG HQAVFEDMPD SDCSDNAPQT VFIIYMYKDS LTRGLAVTIS
110 120 130 140 150
VQCKKMSTLS CKNKTLSFKE MSPPDNIDDE GNDIIFFQRS VPGHDDKIQF
160 170 180 190
ESSLYKGYFL ACKKENDLFK LILKEKDECG DKSIMFTVQN KN
Length:192
Mass (Da):22,026
Last modified:December 15, 1998 - v2
Checksum:i881EA654E221A17A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti184 – 1841I → V in ABF55514 (Ref. 5) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68701 mRNA. Translation: AAC18415.1.
Y11132 mRNA. Translation: CAA72014.1.
AB010003 mRNA. Translation: BAA24135.1.
AF191088 mRNA. Translation: AAF71200.1.
DQ499825 mRNA. Translation: ABF55514.1.
RefSeqiNP_999162.1. NM_213997.1.
XP_005667383.1. XM_005667326.2.
UniGeneiSsc.20.

Genome annotation databases

EnsembliENSSSCT00000016403; ENSSSCP00000015962; ENSSSCG00000015037.
GeneIDi397057.
KEGGissc:397057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68701 mRNA. Translation: AAC18415.1.
Y11132 mRNA. Translation: CAA72014.1.
AB010003 mRNA. Translation: BAA24135.1.
AF191088 mRNA. Translation: AAF71200.1.
DQ499825 mRNA. Translation: ABF55514.1.
RefSeqiNP_999162.1. NM_213997.1.
XP_005667383.1. XM_005667326.2.
UniGeneiSsc.20.

3D structure databases

ProteinModelPortaliO19073.
SMRiO19073. Positions 36-192.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000015962.

Proteomic databases

PaxDbiO19073.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000016403; ENSSSCP00000015962; ENSSSCG00000015037.
GeneIDi397057.
KEGGissc:397057.

Organism-specific databases

CTDi3606.

Phylogenomic databases

eggNOGiENOG410J3U9. Eukaryota.
ENOG410ZGS8. LUCA.
GeneTreeiENSGT00390000001053.
HOGENOMiHOG000048723.
HOVERGENiHBG000388.
InParanoidiO19073.
KOiK05482.
OMAiPVFEDMP.
TreeFamiTF336297.

Enzyme and pathway databases

ReactomeiR-SSC-448706. Interleukin-1 processing.
R-SSC-449147. Signaling by Interleukins.

Gene expression databases

ExpressionAtlasiO19073. differential.
GenevisibleiO19073. SS.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR015529. IL-18.
IPR000975. IL-1_fam.
[Graphical view]
PANTHERiPTHR11326. PTHR11326. 1 hit.
PfamiPF00340. IL1. 1 hit.
[Graphical view]
PIRSFiPIRSF015162. Interleukin_18. 1 hit.
PRINTSiPR01933. INTRLEUKIN18.
SUPFAMiSSF50353. SSF50353. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Foss D.L., Murtaugh M.P.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Penha-Goncalves M.N., Logan N.A., Nicolson L., Onions D.E.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Muneta Y., Mori Y.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Cloning, chromosomal location, and tissue expression of the gene for pig interleukin-18."
    Fournout S., Dozois C.M., Yerle M., Pinton P., Fairbrother J.M., Oswald E., Oswald I.P.
    Immunogenetics 51:358-365(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Intestine.
  5. "Cloning and sequencing of the pig interleukin-18."
    Zheng L., Cui B., Chen H., Fang Z., Chen R.
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiIL18_PIG
AccessioniPrimary (citable) accession number: O19073
Secondary accession number(s): Q1HDI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 15, 1998
Last modified: June 8, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.