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O19071

- MGAT2_PIG

UniProt

O19071 - MGAT2_PIG

Protein

Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Gene

MGAT2

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalyzes an essential step in the conversion of oligo-mannose to complex N-glycans.By similarity

    Catalytic activityi

    UDP-N-acetyl-D-glucosamine + 6-(alpha-D-mannosyl)-beta-D-mannosyl-R = UDP + 6-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R.

    Pathwayi

    GO - Molecular functioni

    1. alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. oligosaccharide biosynthetic process Source: InterPro
    2. protein N-linked glycosylation via asparagine Source: Ensembl

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_220786. Reactions specific to the complex N-glycan synthesis pathway.
    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT16. Glycosyltransferase Family 16.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC:2.4.1.143)
    Alternative name(s):
    Beta-1,2-N-acetylglucosaminyltransferase II
    GlcNAc-T II
    Short name:
    GNT-II
    Mannoside acetylglucosaminyltransferase 2
    N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II
    Gene namesi
    Name:MGAT2
    Synonyms:GNT2
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Chromosome 1

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. Golgi stack Source: InterPro
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 446446Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferasePRO_0000080519Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000005385.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 99CytoplasmicSequence Analysis
    Topological domaini30 – 446417LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 2920Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG239633.
    GeneTreeiENSGT00390000007341.
    HOGENOMiHOG000261661.
    HOVERGENiHBG052467.
    KOiK00736.
    OMAiHAGDCGM.
    OrthoDBiEOG7TF79W.
    TreeFamiTF314772.

    Family and domain databases

    Gene3Di3.90.550.10. 2 hits.
    InterProiIPR007754. GlcNAc_II.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PANTHERiPTHR12871. PTHR12871. 1 hit.
    PfamiPF05060. MGAT2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    O19071-1 [UniParc]FASTAAdd to Basket

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    MRFRIYKRKV LILTFVVAAC GFVLWSSNGR QRKNEALAPP LLDAEPVRGA    50
    GARAGDHPAI SVGIRRGSND SAAPLVAAAP QPEVDNLTLR YRSLVYQLNF 100
    DQTLRNVDKV SSWVPRELVL VVQVHNRAEY LKLLLDSLRK AQGIDNVLVI 150
    FSHDFWSTEI NQLIAGVDFC PVLQVFFPFS IQLYPNEFPG TDPRDCPRDL 200
    EKNAALKMGC INAEYPDSFG HYREAKFSQT KHHWWWKLHF VWERVKVLRD 250
    YAGLILFLEE DHYVAPDFYH VFKKMWNLKQ QECPECDVLS LGTYTTVRSF 300
    RDVADKVDVK TWKSTEHNMG LALTRDAYQK LIECTDTFCT YDDYNWDWTL 350
    QYLTVSCLPK FWKVLVPQVP RIFHAGDCGM HHKKTCRPST QSAQIESLLN 400
    SNKQYMFPET LTISEKLTAA LSPPRKNGGW GDIRDHELCK SYRRLQ 446
    Length:446
    Mass (Da):51,527
    Last modified:January 1, 1998 - v1
    Checksum:i9B03F1C20778D897
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y09537 Genomic DNA. Translation: CAA70732.1.
    RefSeqiNP_001121954.1. NM_001128482.1.
    UniGeneiSsc.43963.
    Ssc.94564.

    Genome annotation databases

    EnsembliENSSSCT00000005522; ENSSSCP00000005385; ENSSSCG00000005006.
    GeneIDi100151745.
    KEGGissc:100151745.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y09537 Genomic DNA. Translation: CAA70732.1 .
    RefSeqi NP_001121954.1. NM_001128482.1.
    UniGenei Ssc.43963.
    Ssc.94564.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000005385.

    Protein family/group databases

    CAZyi GT16. Glycosyltransferase Family 16.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSSCT00000005522 ; ENSSSCP00000005385 ; ENSSSCG00000005006 .
    GeneIDi 100151745.
    KEGGi ssc:100151745.

    Organism-specific databases

    CTDi 4247.

    Phylogenomic databases

    eggNOGi NOG239633.
    GeneTreei ENSGT00390000007341.
    HOGENOMi HOG000261661.
    HOVERGENi HBG052467.
    KOi K00736.
    OMAi HAGDCGM.
    OrthoDBi EOG7TF79W.
    TreeFami TF314772.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    Reactomei REACT_220786. Reactions specific to the complex N-glycan synthesis pathway.

    Family and domain databases

    Gene3Di 3.90.550.10. 2 hits.
    InterProi IPR007754. GlcNAc_II.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    PANTHERi PTHR12871. PTHR12871. 1 hit.
    Pfami PF05060. MGAT2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the porcine beta-1,2-N-acetylglucosaminyltransferase II gene and assignment to chromosome 1q23-q27."
      Leeb T., Kriegesmann B., Baumgartner B., Klett C., Yerle M., Hameister H., Brenig B.
      Biochim. Biophys. Acta 1336:361-366(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Brain and Liver.

    Entry informationi

    Entry nameiMGAT2_PIG
    AccessioniPrimary (citable) accession number: O19071
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways

    External Data

    Dasty 3