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O19071 (MGAT2_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

EC=2.4.1.143
Alternative name(s):
Beta-1,2-N-acetylglucosaminyltransferase II
GlcNAc-T II
Short name=GNT-II
Mannoside acetylglucosaminyltransferase 2
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II
Gene names
Name:MGAT2
Synonyms:GNT2
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length446 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes an essential step in the conversion of oligo-mannose to complex N-glycans By similarity.

Catalytic activity

UDP-N-acetyl-D-glucosamine + 6-(alpha-D-mannosyl)-beta-D-mannosyl-R = UDP + 6-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Golgi apparatus membrane; Single-pass type II membrane protein By similarity.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 446446Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
PRO_0000080519

Regions

Topological domain1 – 99Cytoplasmic Potential
Transmembrane10 – 2920Helical; Signal-anchor for type II membrane protein; Potential
Topological domain30 – 446417Lumenal Potential

Amino acid modifications

Glycosylation691N-linked (GlcNAc...) Potential
Glycosylation861N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O19071 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 9B03F1C20778D897

FASTA44651,527
        10         20         30         40         50         60 
MRFRIYKRKV LILTFVVAAC GFVLWSSNGR QRKNEALAPP LLDAEPVRGA GARAGDHPAI 

        70         80         90        100        110        120 
SVGIRRGSND SAAPLVAAAP QPEVDNLTLR YRSLVYQLNF DQTLRNVDKV SSWVPRELVL 

       130        140        150        160        170        180 
VVQVHNRAEY LKLLLDSLRK AQGIDNVLVI FSHDFWSTEI NQLIAGVDFC PVLQVFFPFS 

       190        200        210        220        230        240 
IQLYPNEFPG TDPRDCPRDL EKNAALKMGC INAEYPDSFG HYREAKFSQT KHHWWWKLHF 

       250        260        270        280        290        300 
VWERVKVLRD YAGLILFLEE DHYVAPDFYH VFKKMWNLKQ QECPECDVLS LGTYTTVRSF 

       310        320        330        340        350        360 
RDVADKVDVK TWKSTEHNMG LALTRDAYQK LIECTDTFCT YDDYNWDWTL QYLTVSCLPK 

       370        380        390        400        410        420 
FWKVLVPQVP RIFHAGDCGM HHKKTCRPST QSAQIESLLN SNKQYMFPET LTISEKLTAA 

       430        440 
LSPPRKNGGW GDIRDHELCK SYRRLQ 

« Hide

References

[1]"Molecular cloning of the porcine beta-1,2-N-acetylglucosaminyltransferase II gene and assignment to chromosome 1q23-q27."
Leeb T., Kriegesmann B., Baumgartner B., Klett C., Yerle M., Hameister H., Brenig B.
Biochim. Biophys. Acta 1336:361-366(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Brain and Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y09537 Genomic DNA. Translation: CAA70732.1.
RefSeqNP_001121954.1. NM_001128482.1.
UniGeneSsc.43963.
Ssc.94564.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9823.ENSSSCP00000005385.

Protein family/group databases

CAZyGT16. Glycosyltransferase Family 16.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSSSCT00000005522; ENSSSCP00000005385; ENSSSCG00000005006.
GeneID100151745.
KEGGssc:100151745.

Organism-specific databases

CTD4247.

Phylogenomic databases

eggNOGNOG239633.
GeneTreeENSGT00390000007341.
HOGENOMHOG000261661.
HOVERGENHBG052467.
KOK00736.
OMAHAGDCGM.
OrthoDBEOG7TF79W.
TreeFamTF314772.

Enzyme and pathway databases

UniPathwayUPA00378.

Family and domain databases

Gene3D3.90.550.10. 2 hits.
InterProIPR007754. GlcNAc_II.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERPTHR12871. PTHR12871. 1 hit.
PfamPF05060. MGAT2. 1 hit.
[Graphical view]
SUPFAMSSF53448. SSF53448. 2 hits.
ProtoNetSearch...

Entry information

Entry nameMGAT2_PIG
AccessionPrimary (citable) accession number: O19071
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: January 1, 1998
Last modified: June 11, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways