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O19071

- MGAT2_PIG

UniProt

O19071 - MGAT2_PIG

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Protein

Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Gene
MGAT2, GNT2
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes an essential step in the conversion of oligo-mannose to complex N-glycans By similarity.

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 6-(alpha-D-mannosyl)-beta-D-mannosyl-R = UDP + 6-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R.

Pathwayi

GO - Molecular functioni

  1. alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. oligosaccharide biosynthetic process Source: InterPro
  2. protein N-linked glycosylation via asparagine Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_220786. Reactions specific to the complex N-glycan synthesis pathway.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT16. Glycosyltransferase Family 16.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC:2.4.1.143)
Alternative name(s):
Beta-1,2-N-acetylglucosaminyltransferase II
GlcNAc-T II
Short name:
GNT-II
Mannoside acetylglucosaminyltransferase 2
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II
Gene namesi
Name:MGAT2
Synonyms:GNT2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99Cytoplasmic Reviewed prediction
Transmembranei10 – 2920Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini30 – 446417Lumenal Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. Golgi stack Source: InterPro
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferasePRO_0000080519Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi69 – 691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi86 – 861N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000005385.

Family & Domainsi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG239633.
GeneTreeiENSGT00390000007341.
HOGENOMiHOG000261661.
HOVERGENiHBG052467.
KOiK00736.
OMAiHAGDCGM.
OrthoDBiEOG7TF79W.
TreeFamiTF314772.

Family and domain databases

Gene3Di3.90.550.10. 2 hits.
InterProiIPR007754. GlcNAc_II.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR12871. PTHR12871. 1 hit.
PfamiPF05060. MGAT2. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 2 hits.

Sequencei

Sequence statusi: Complete.

O19071-1 [UniParc]FASTAAdd to Basket

« Hide

MRFRIYKRKV LILTFVVAAC GFVLWSSNGR QRKNEALAPP LLDAEPVRGA    50
GARAGDHPAI SVGIRRGSND SAAPLVAAAP QPEVDNLTLR YRSLVYQLNF 100
DQTLRNVDKV SSWVPRELVL VVQVHNRAEY LKLLLDSLRK AQGIDNVLVI 150
FSHDFWSTEI NQLIAGVDFC PVLQVFFPFS IQLYPNEFPG TDPRDCPRDL 200
EKNAALKMGC INAEYPDSFG HYREAKFSQT KHHWWWKLHF VWERVKVLRD 250
YAGLILFLEE DHYVAPDFYH VFKKMWNLKQ QECPECDVLS LGTYTTVRSF 300
RDVADKVDVK TWKSTEHNMG LALTRDAYQK LIECTDTFCT YDDYNWDWTL 350
QYLTVSCLPK FWKVLVPQVP RIFHAGDCGM HHKKTCRPST QSAQIESLLN 400
SNKQYMFPET LTISEKLTAA LSPPRKNGGW GDIRDHELCK SYRRLQ 446
Length:446
Mass (Da):51,527
Last modified:January 1, 1998 - v1
Checksum:i9B03F1C20778D897
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y09537 Genomic DNA. Translation: CAA70732.1.
RefSeqiNP_001121954.1. NM_001128482.1.
UniGeneiSsc.43963.
Ssc.94564.

Genome annotation databases

EnsembliENSSSCT00000005522; ENSSSCP00000005385; ENSSSCG00000005006.
GeneIDi100151745.
KEGGissc:100151745.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y09537 Genomic DNA. Translation: CAA70732.1 .
RefSeqi NP_001121954.1. NM_001128482.1.
UniGenei Ssc.43963.
Ssc.94564.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000005385.

Protein family/group databases

CAZyi GT16. Glycosyltransferase Family 16.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000005522 ; ENSSSCP00000005385 ; ENSSSCG00000005006 .
GeneIDi 100151745.
KEGGi ssc:100151745.

Organism-specific databases

CTDi 4247.

Phylogenomic databases

eggNOGi NOG239633.
GeneTreei ENSGT00390000007341.
HOGENOMi HOG000261661.
HOVERGENi HBG052467.
KOi K00736.
OMAi HAGDCGM.
OrthoDBi EOG7TF79W.
TreeFami TF314772.

Enzyme and pathway databases

UniPathwayi UPA00378 .
Reactomei REACT_220786. Reactions specific to the complex N-glycan synthesis pathway.

Family and domain databases

Gene3Di 3.90.550.10. 2 hits.
InterProi IPR007754. GlcNAc_II.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
PANTHERi PTHR12871. PTHR12871. 1 hit.
Pfami PF05060. MGAT2. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of the porcine beta-1,2-N-acetylglucosaminyltransferase II gene and assignment to chromosome 1q23-q27."
    Leeb T., Kriegesmann B., Baumgartner B., Klett C., Yerle M., Hameister H., Brenig B.
    Biochim. Biophys. Acta 1336:361-366(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Brain and Liver.

Entry informationi

Entry nameiMGAT2_PIG
AccessioniPrimary (citable) accession number: O19071
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

External Data

Dasty 3

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