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O19071

- MGAT2_PIG

UniProt

O19071 - MGAT2_PIG

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Protein

Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Gene

MGAT2

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes an essential step in the conversion of oligo-mannose to complex N-glycans.By similarity

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 6-(alpha-D-mannosyl)-beta-D-mannosyl-R = UDP + 6-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R.

Pathwayi

GO - Molecular functioni

  1. alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. oligosaccharide biosynthetic process Source: InterPro
  2. protein N-linked glycosylation via asparagine Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_220786. Reactions specific to the complex N-glycan synthesis pathway.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT16. Glycosyltransferase Family 16.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC:2.4.1.143)
Alternative name(s):
Beta-1,2-N-acetylglucosaminyltransferase II
GlcNAc-T II
Short name:
GNT-II
Mannoside acetylglucosaminyltransferase 2
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II
Gene namesi
Name:MGAT2
Synonyms:GNT2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99CytoplasmicSequence Analysis
Transmembranei10 – 2920Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini30 – 446417LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi stack Source: InterPro
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferasePRO_0000080519Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000005385.

Family & Domainsi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG239633.
GeneTreeiENSGT00390000007341.
HOGENOMiHOG000261661.
HOVERGENiHBG052467.
InParanoidiO19071.
KOiK00736.
OMAiHAGDCGM.
OrthoDBiEOG7TF79W.
TreeFamiTF314772.

Family and domain databases

Gene3Di3.90.550.10. 2 hits.
InterProiIPR007754. GlcNAc_II.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR12871. PTHR12871. 1 hit.
PfamiPF05060. MGAT2. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 2 hits.

Sequencei

Sequence statusi: Complete.

O19071-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRFRIYKRKV LILTFVVAAC GFVLWSSNGR QRKNEALAPP LLDAEPVRGA
60 70 80 90 100
GARAGDHPAI SVGIRRGSND SAAPLVAAAP QPEVDNLTLR YRSLVYQLNF
110 120 130 140 150
DQTLRNVDKV SSWVPRELVL VVQVHNRAEY LKLLLDSLRK AQGIDNVLVI
160 170 180 190 200
FSHDFWSTEI NQLIAGVDFC PVLQVFFPFS IQLYPNEFPG TDPRDCPRDL
210 220 230 240 250
EKNAALKMGC INAEYPDSFG HYREAKFSQT KHHWWWKLHF VWERVKVLRD
260 270 280 290 300
YAGLILFLEE DHYVAPDFYH VFKKMWNLKQ QECPECDVLS LGTYTTVRSF
310 320 330 340 350
RDVADKVDVK TWKSTEHNMG LALTRDAYQK LIECTDTFCT YDDYNWDWTL
360 370 380 390 400
QYLTVSCLPK FWKVLVPQVP RIFHAGDCGM HHKKTCRPST QSAQIESLLN
410 420 430 440
SNKQYMFPET LTISEKLTAA LSPPRKNGGW GDIRDHELCK SYRRLQ
Length:446
Mass (Da):51,527
Last modified:January 1, 1998 - v1
Checksum:i9B03F1C20778D897
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09537 Genomic DNA. Translation: CAA70732.1.
RefSeqiNP_001121954.1. NM_001128482.1.
UniGeneiSsc.43963.
Ssc.94564.

Genome annotation databases

EnsembliENSSSCT00000005522; ENSSSCP00000005385; ENSSSCG00000005006.
GeneIDi100151745.
KEGGissc:100151745.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09537 Genomic DNA. Translation: CAA70732.1 .
RefSeqi NP_001121954.1. NM_001128482.1.
UniGenei Ssc.43963.
Ssc.94564.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000005385.

Protein family/group databases

CAZyi GT16. Glycosyltransferase Family 16.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000005522 ; ENSSSCP00000005385 ; ENSSSCG00000005006 .
GeneIDi 100151745.
KEGGi ssc:100151745.

Organism-specific databases

CTDi 4247.

Phylogenomic databases

eggNOGi NOG239633.
GeneTreei ENSGT00390000007341.
HOGENOMi HOG000261661.
HOVERGENi HBG052467.
InParanoidi O19071.
KOi K00736.
OMAi HAGDCGM.
OrthoDBi EOG7TF79W.
TreeFami TF314772.

Enzyme and pathway databases

UniPathwayi UPA00378 .
Reactomei REACT_220786. Reactions specific to the complex N-glycan synthesis pathway.

Family and domain databases

Gene3Di 3.90.550.10. 2 hits.
InterProi IPR007754. GlcNAc_II.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
PANTHERi PTHR12871. PTHR12871. 1 hit.
Pfami PF05060. MGAT2. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of the porcine beta-1,2-N-acetylglucosaminyltransferase II gene and assignment to chromosome 1q23-q27."
    Leeb T., Kriegesmann B., Baumgartner B., Klett C., Yerle M., Hameister H., Brenig B.
    Biochim. Biophys. Acta 1336:361-366(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Brain and Liver.

Entry informationi

Entry nameiMGAT2_PIG
AccessioniPrimary (citable) accession number: O19071
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

External Data

Dasty 3