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Protein

Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Gene

MGAT2

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes an essential step in the conversion of oligo-mannose to complex N-glycans.By similarity

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 6-(alpha-D-mannosyl)-beta-D-mannosyl-R = UDP + 6-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-SSC-975578. Reactions specific to the complex N-glycan synthesis pathway.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT16. Glycosyltransferase Family 16.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC:2.4.1.143)
Alternative name(s):
Beta-1,2-N-acetylglucosaminyltransferase II
GlcNAc-T II
Short name:
GNT-II
Mannoside acetylglucosaminyltransferase 2
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II
Gene namesi
Name:MGAT2
Synonyms:GNT2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 29Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST20
Topological domaini30 – 446LumenalSequence analysisAdd BLAST417

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000805191 – 446Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferaseAdd BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO19071.
PRIDEiO19071.

Expressioni

Gene expression databases

BgeeiENSSSCG00000005006.
GenevisibleiO19071. SS.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000005385.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2791. Eukaryota.
ENOG410XPYF. LUCA.
GeneTreeiENSGT00390000007341.
HOGENOMiHOG000261661.
HOVERGENiHBG052467.
InParanoidiO19071.
KOiK00736.
OMAiRDHELCK.
OrthoDBiEOG091G05U3.
TreeFamiTF314772.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiView protein in InterPro
IPR007754. GlcNAc_II.
IPR029044. Nucleotide-diphossugar_trans.
PANTHERiPTHR12871. PTHR12871. 1 hit.
PfamiView protein in Pfam
PF05060. MGAT2. 1 hit.
SUPFAMiSSF53448. SSF53448. 2 hits.

Sequencei

Sequence statusi: Complete.

O19071-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFRIYKRKV LILTFVVAAC GFVLWSSNGR QRKNEALAPP LLDAEPVRGA
60 70 80 90 100
GARAGDHPAI SVGIRRGSND SAAPLVAAAP QPEVDNLTLR YRSLVYQLNF
110 120 130 140 150
DQTLRNVDKV SSWVPRELVL VVQVHNRAEY LKLLLDSLRK AQGIDNVLVI
160 170 180 190 200
FSHDFWSTEI NQLIAGVDFC PVLQVFFPFS IQLYPNEFPG TDPRDCPRDL
210 220 230 240 250
EKNAALKMGC INAEYPDSFG HYREAKFSQT KHHWWWKLHF VWERVKVLRD
260 270 280 290 300
YAGLILFLEE DHYVAPDFYH VFKKMWNLKQ QECPECDVLS LGTYTTVRSF
310 320 330 340 350
RDVADKVDVK TWKSTEHNMG LALTRDAYQK LIECTDTFCT YDDYNWDWTL
360 370 380 390 400
QYLTVSCLPK FWKVLVPQVP RIFHAGDCGM HHKKTCRPST QSAQIESLLN
410 420 430 440
SNKQYMFPET LTISEKLTAA LSPPRKNGGW GDIRDHELCK SYRRLQ
Length:446
Mass (Da):51,527
Last modified:January 1, 1998 - v1
Checksum:i9B03F1C20778D897
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09537 Genomic DNA. Translation: CAA70732.1.
RefSeqiNP_001121954.1. NM_001128482.1.
UniGeneiSsc.43963.
Ssc.94564.

Genome annotation databases

EnsembliENSSSCT00000005522; ENSSSCP00000005385; ENSSSCG00000005006.
GeneIDi100151745.
KEGGissc:100151745.

Similar proteinsi

Entry informationi

Entry nameiMGAT2_PIG
AccessioniPrimary (citable) accession number: O19071
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: January 1, 1998
Last modified: September 27, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families